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01-08-2017 | Original Article

Zero hospital admissions for infection after 577 transperineal prostate biopsies using single-dose cephazolin prophylaxis

Authors: Lana Pepdjonovic, Guan Hee Tan, Sean Huang, Sarah Mann, Mark Frydenberg, Daniel Moon, Uri Hanegbi, Adam Landau, Ross Snow, Jeremy Grummet

Published in: World Journal of Urology | Issue 8/2017

Abstract

Purpose

To determine the rate of hospital admissions for infection after transperineal biopsy of prostate (TPB) with single-dose cephazolin prophylaxis using a prospective database.

Method

Between April 2013 and February 2016, 577 patients undergoing TPB had 2 g of cephazolin given intravenously at induction of anaesthesia. Data collected from these patients included age, PSA, prostate volume, number of cores taken and post-operative complications.

Results

No patients were readmitted to hospital with infection post-TPB. Seven patients developed acute urinary retention, and one patient developed clinical prostatitis that was treated with oral antibiotics in the community.

Conclusion

It is safe to use single-dose cephazolin only as antibiotic prophylaxis prior to TPB, negating the need for quinolones. This study supports Australia’s current Therapeutic Guidelines recommendation for TPB prophylaxis and the existing evidence that sepsis post-TPB is a rare complication. Whether any antibiotic prophylaxis is needed at all for TPB is the subject of a future study.

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Title: Zero hospital admissions for infection after 577 transperineal prostate biopsies using single-dose cephazolin prophylaxis
Authors: Lana Pepdjonovic
Guan Hee Tan
Sean Huang
Sarah Mann
Mark Frydenberg
Daniel Moon
Uri Hanegbi
Adam Landau
Ross Snow
Jeremy Grummet
Publication date: 01-08-2017
Publisher: Springer Berlin Heidelberg
Published in: World Journal of Urology / Issue 8/2017
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-016-1985-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Zero hospital admissions for infection after 577 transperineal prostate biopsies using single-dose cephazolin prophylaxis

Abstract

Purpose

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Method

Results

Conclusion

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