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BMC Medicine
Published in: BMC Medicine 1/2022

Open Access 01-12-2022 | Research article

Your height affects your health: genetic determinants and health-related outcomes in Taiwan

Authors: Jian-Shiun Chiou, Chi-Fung Cheng, Wen-Miin Liang, Chen-Hsing Chou, Chung-Hsing Wang, Wei-De Lin, Mu-Lin Chiu, Wei-Chung Cheng, Cheng-Wen Lin, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Chang-Hai Tsai, Ying-Ju Lin, Fuu-Jen Tsai

Published in: BMC Medicine | Issue 1/2022

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Abstract

Background

Height is an important anthropometric measurement and is associated with many health-related outcomes. Genome-wide association studies (GWASs) have identified hundreds of genetic loci associated with height, mainly in individuals of European ancestry.

Methods

We performed genome-wide association analyses and replicated previously reported GWAS-determined single nucleotide polymorphisms (SNPs) in the Taiwanese Han population (Taiwan Biobank; n = 67,452). A genetic instrument composed of 251 SNPs was selected from our GWAS, based on height and replication results as the best-fit polygenic risk score (PRS), in accordance with the clumping and p-value threshold method. We also examined the association between genetically determined height (PRS251) and measured height (phenotype). We performed observational (phenotype) and genetic PRS251 association analyses of height and health-related outcomes.

Results

GWAS identified 6843 SNPs in 89 genomic regions with genome-wide significance, including 18 novel loci. These were the most strongly associated genetic loci (EFEMP1, DIS3L2, ZBTB38, LCORL, HMGA1, CS, and GDF5) previously reported to play a role in height. There was a positive association between PRS251 and measured height (p < 0.001). Of the 14 traits and 49 diseases analyzed, we observed significant associations of measured and genetically determined height with only eight traits (p < 0.05/[14 + 49]). Height was positively associated with body weight, waist circumference, and hip circumference but negatively associated with body mass index, waist-hip ratio, body fat, total cholesterol, and low-density lipoprotein cholesterol (p < 0.05/[14 + 49]).

Conclusions

This study contributes to the understanding of the genetic features of height and health-related outcomes in individuals of Han Chinese ancestry in Taiwan.
Appendix
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Metadata
Title
Your height affects your health: genetic determinants and health-related outcomes in Taiwan
Authors
Jian-Shiun Chiou
Chi-Fung Cheng
Wen-Miin Liang
Chen-Hsing Chou
Chung-Hsing Wang
Wei-De Lin
Mu-Lin Chiu
Wei-Chung Cheng
Cheng-Wen Lin
Ting-Hsu Lin
Chiu-Chu Liao
Shao-Mei Huang
Chang-Hai Tsai
Ying-Ju Lin
Fuu-Jen Tsai
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2022
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-022-02450-w

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