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Techniques in Coloproctology

Published in:

01-09-2009 | Original Article

Young-age onset of colorectal cancer in Israel

Authors: D. Neufeld, B. Shpitz, N. Bugaev, M. Grankin, J. Bernheim, E. Klein, Y. Ziv

Published in: Techniques in Coloproctology | Issue 3/2009

Abstract

Aim

The study was conducted to investigate the differences in clinical–pathological, ethnic, and demographic presentations and the expression of mismatch repair proteins in a cohort of young-onset (≤50 years) versus late-onset Israeli patients (>50 years) with colorectal cancer.

Materials and methods

Clinical, demographic, and histopathological data of patients with colorectal cancer were collected retrospectively from medical records and pathology reports.

Results

Ninety patients, 50 years of age or younger with a mean age of 42 years were compared with a group of 190 patients above 50 years of 50 (see Table 1). Sixty percent of the young-onset patients were females, compared to 40% in the older age group (P = 0.02). Twenty-one percent of the young-onset patients were Arabs as compared to 2% of older-onset patients (P = 0.001). Younger patients displayed a higher percentage of mucinous cancers and a higher percentage of diagnosis at an advanced stage of disease; 40% of young-onset versus 31% of older-onset patients presented Duke’s stages C and D (P = 0.02).

Conclusions

Younger age of onset colorectal cancer in our cohort of Israeli patients is associated with higher percentage of Arab patients, mucinous cancers, female gender, and advanced stage at diagnosis.

Jemal A, Tiwari RC, Murray T et al (2004) Cancer statistics 2004. CA Cancer J Clin 54:8–29PubMedCrossRef

Boyle P, Leon ME (2002) Epidemiology of colorectal cancer. Br Med Bull 64:1–25PubMedCrossRef

Leong QM, Koh DC, Ho CK (2008) Emergency Hartmann’s procedure: morbidity, mortality and reversal rates among Asians. Tech Coloproctol 12:21–25PubMedCrossRef

O’Connell JB, Maggard MA, Livingston EH et al (2004) Colorectal cancer in the young. Am J Surg 187:343–348PubMedCrossRef

Kaw L, Punzalan C, Crisostomo AC et al (2002) Surgical pathology of colorectal cancer in Filipinos: implications for surgical practice. J Am Coll Surg 195:188–195PubMedCrossRef

Griffin PM, Liff JM, Greenberg RS et al (1991) Adenocarcinomas of the colon and rectum in persons under 40 years old. A population based study. Gastroenterology 100:1033–1040PubMed

O’Connell JB, Maggard MA, Liu JH et al (2003) Rates of colon and rectal cancers are increasing in young adults. Am Surg 69:866–872PubMed

Minardi AJ, Sittig KM, Zibari GB et al (1998) Colorectal cancer in the young. Am Surg 64:849–853PubMed

Barchana M, Liphshitz I, Rozen P (2004) Trends in colorectal cancer incidence and mortality in the Israeli Jewish ethnic populations. Fam Cancer 3:207–214PubMedCrossRef

10.

Israel Cancer Registry. http://www.health.gov.il/icr/

11.

Fireman Z, Sandler E, Kopelman Y et al (2001) Ethnic differences in colorectal cancer among Arab and Jewish neighbors in Israel. Am J Gastroenterol 96:204–207PubMedCrossRef

12.

Abou-Zeid AA, Khafagy W, Marzouk D et al (2002) Colorectal cancer in Egypt. Dis Colon Rectum 45:255–260CrossRef

13.

Soliman AS, Bondy ML, El-Badawy SA et al (2001) Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients. Br J Cancer 85:1037–1046PubMedCrossRef

14.

Lindor NM, Burgart LJ, Leontovich O et al (2002) Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. J Clin Oncol 20:1043–1048PubMedCrossRef

15.

Chiang JM, Chen MC, Changchien CR et al (2003) Favorable influence of age on tumor characteristics of sporadic colorectal adenocarcinoma: patients 30 years of age or younger may be a distinct patient group. Dis Colon Rectum 46:904–910PubMedCrossRef

16.

Liang JT, Huang KC, Cheng AL et al (2003) Clinicopathological and molecular biological features of colorectal cancer in patients less than 40 years of age. Br J Surg 90:205–214PubMedCrossRef

17.

Ho JW, Yuen S, Chung L et al (2000) Distinct clinical features associated with microsatellite instability in colorectal cancer of young patients. Int J Cancer 89:356–360PubMedCrossRef

18.

Paraf F, Jothy S (2000) Colorectal cancer before age of 40: a case-control study. Dis Colon Rectum 43:1222–1226PubMedCrossRef

19.

Suh JH, Lim S-D, Kim JC et al (2002) Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instability-positive and microsatellite instability-negative sporadic colorectal carcinomas in patients younger than 40 years old. Dis Colon Rectum 45:219–228PubMedCrossRef

20.

Burger-Weiser G, Waterhouse L, Richter S et al (2003) Increased frequency of colonic polyps leading to colon cancer among women. Arch Med Res 34:152–153PubMedCrossRef

Title: Young-age onset of colorectal cancer in Israel
Authors: D. Neufeld
B. Shpitz
N. Bugaev
M. Grankin
J. Bernheim
E. Klein
Y. Ziv
Publication date: 01-09-2009
Publisher: Springer Milan
Published in: Techniques in Coloproctology / Issue 3/2009
Print ISSN: 1123-6337
Electronic ISSN: 1128-045X
DOI: https://doi.org/10.1007/s10151-009-0501-7

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Springer Medicine

Young-age onset of colorectal cancer in Israel

Abstract

Aim

Materials and methods

Results

Conclusions

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Springer Medicine

Abstract

Aim

Materials and methods

Results

Conclusions

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