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Inflammopharmacology
Published in: Inflammopharmacology 5/2017

01-10-2017 | Short Communication

Yeast RNA extract suppresses human osteoclast resorption in vitro

Authors: Melissa D. Cantley, K. D. Rainsford, David R. Haynes

Published in: Inflammopharmacology | Issue 5/2017

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Abstract

Aims

The aim of this short study was to test the combinations of RNA extracts (both the connective tissue extracts—cartilage and synovia along with yeast extract) found in natural ribonucleotide extract Osteochondrin S (OST) on human osteoclast formation and activity in vitro.

Methods

In vitro human osteoclasts were treated with the RNA extracts (cartilage, synovia and yeast) at concentrations equivalent to those in OST starting from day 7 of the culture. A tartrate resistant acid phosphatase stain (TRAP) was used to indicate osteoclast formation and activity assessed by determining area of dentine resorption.

Results

The combination of all components as is found in OST suppressed both osteoclast formation and activity. The yeast extract suppressed osteoclast activity at similar levels to that observed with all components combined.

Conclusions

Our findings indicate that yeast RNA extracts found in OST may be the key component responsible for suppression of osteoclast activity.
Literature
Cantley MD, Rainsford KD, Haynes DR (2013) Effects of Osteochondrin S and select connective tissue ribonucleinate components on human osteoclasts in vitro. J Pharm Pharmacol 65(8):1214–1222CrossRefPubMed
Lodemann E, Hochheimer G, Pilgramm M (1989) Biologische Wirkungen eines Ribonucleinsäurehaltigen Arzneimittels. Erfahrungsheilkunde. 8:490–494
Rainsford KD (1996) Mode of Action, uses and side effects of anti-inflammatory drugs. In: Advances in Anti-Rheumatic Therapy: CRC Press
Rainsford K, Bolten W, Schühlein K-H, Dempsey A, Schnitker J (2004) Effects of intramuscular sodium ribonucleinate (Osteochondrin® S) in osteoarthritis of the knee: identification of Responders and Non-Responders. Ann Rheum Dis 63(Suppl. 1):Abst FRI0–406
Rainsford K, Jonas A, Ying C, Smith F (2008) Ribonucleate sodium [Osteochondrin® S] inhibits cytokine-induced cartilage-bone degradation but not proteoglycan synthesis. Inflammopharmacology 16(321) Abstract No. P17
Rainsford KD, Powanda MC, Whitehouse MW (2015) Novel natural products: therapeutic effects in pain, arthritis and gastro-intestinal diseases. In: Rainsford KD (ed), Springer
Schroeder A, Dorn M, Schühlein K-H, von Sulecki W (1989) Die Behandlung Degenerativer Gelenkerkrankungen. Therapiewoche. 39:2310
Stommel G, Bolten W, Rainsford K, Schühlein K-H, Dempsey A, Schnitker J (2008) Safety and efficacy of intramuscular sodium ribonucleinate [Osteochondrin® S] for relief of pain and joint functions in knee osteoarthritis. Inflammopharmacology 16(Abstract No. P2):310–311
Von Sulecki W (1990) Symposium on Regeneresen. Laboratorium Dyckerhoff GmbH, Köln
Metadata
Title
Yeast RNA extract suppresses human osteoclast resorption in vitro
Authors
Melissa D. Cantley
K. D. Rainsford
David R. Haynes
Publication date
01-10-2017
Publisher
Springer International Publishing
Published in
Inflammopharmacology / Issue 5/2017
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-017-0351-2

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