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Open Access 01-02-2013 | Year in Review 2012

Year in review in Intensive Care Medicine 2012: I. Neurology and neurointensive care, epidemiology and nephrology, biomarkers and inflammation, nutrition, experimentals

Authors: Massimo Antonelli, Marc Bonten, Maurizio Cecconi, Jean Chastre, Giuseppe Citerio, Giorgio Conti, J. Randall Curtis, Goran Hedenstierna, Michael Joannidis, Duncan Macrae, Salvatore M. Maggiore, Jordi Mancebo, Alexandre Mebazaa, Jean-Charles Preiser, Patricia Rocco, Jean-François Timsit, Jan Wernerman, Haibo Zhang

Published in: Intensive Care Medicine | Issue 2/2013

Excerpt

Elevated intracranial pressure (ICP) has been associated with increased mortality in patients with severe traumatic brain injury (TBI). More than 20 years ago, Marmarou [1], while analysing the data from the traumatic coma data bank (TCDB), recognized that the proportion of hourly ICP readings greater than 20 mmHg was fundamental in explaining long-term outcome in TBI victims. Since that moment, the cutoff point of 20 mmHg has been selected as most indicative in neurotraumatology. Not only times spent over the threshold, but also the responses to the therapy are crucial. Following this concept, Treggiari [2] systematically reviewed the literature to estimate the association between ICP patterns and outcome. Confirming Marmarou’s observations, raised ICP, i.e. an ICP >20 mmHg, was associated with an increased probability of death. Moreover, if ICP was raised but treatable, this condition was associated with a threefold to fourfold increase in the probability of death or poor neurological outcome. If ICP was raised and refractory, this was associated with a dramatic increase in the relative risk of death (OR 114.3). Therefore, refractory ICP and response to ICP treatment could be better predictors of neurological outcome than absolute ICP values. …

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Title: Year in review in Intensive Care Medicine 2012: I. Neurology and neurointensive care, epidemiology and nephrology, biomarkers and inflammation, nutrition, experimentals
Authors: Massimo Antonelli
Marc Bonten
Maurizio Cecconi
Jean Chastre
Giuseppe Citerio
Giorgio Conti
J. Randall Curtis
Goran Hedenstierna
Michael Joannidis
Duncan Macrae
Salvatore M. Maggiore
Jordi Mancebo
Alexandre Mebazaa
Jean-Charles Preiser
Patricia Rocco
Jean-François Timsit
Jan Wernerman
Haibo Zhang
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 2/2013
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-012-2774-y

At a glance: The STEP trials

Springer Medicine

Year in review in Intensive Care Medicine 2012: I. Neurology and neurointensive care, epidemiology and nephrology, biomarkers and inflammation, nutrition, experimentals

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At a glance: The STEP trials

Springer Medicine

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