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International Ophthalmology

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Open Access 01-11-2020 | Xerophthalmia | Original Paper

Evaluation of objective visual quality in dry eye disease and corneal nerve changes

Authors: Jiahui Ma, Shanshan Wei, Xiaodan Jiang, Yilin Chou, Yuexin Wang, Ran Hao, Jiarui Yang, Xuemin Li

Published in: International Ophthalmology | Issue 11/2020

Abstract

Purpose

To explore objective visual quality in dry eye diseases (DED) and the correlation between corneal nerves and objective visual quality.

Methods

Ninety-eight eyes of 49 patients with DED were included. Each patient was evaluated with the ocular surface disease index (OSDI), eyelid margin signs and meibomian gland assessments; corneal staining; tear film breakup time (TBUT); tear meniscus height (TMH); in vivo confocal microscopic (IVCM); objective visual quality including the objective scatter index (OSI), mean objective scattering index (mOSI), modulation transfer function (MTF) cutoff value and Strehl ratio.

Results

A significant correlation was found between the OSDI and mOSI (r = 0.422, p = 0.005), MTF cutoff value (r = − 0.355, p = 0.020), and Strehl ratio (r = − 0.446, p = 0.003). The OSI was significantly correlated with TBUTf (r = − 0.213, p = 0.042). The mOSI, MTF cutoff value, Strehl ratio were correlated with eyelid margin signs and meibomian assessments. Additionally, there was a statistically significant correlation between corneal nerve length and the mOSI (r = − 0.239, p = 0.037), OSI (r = − 0.294, p = 0.028), MTF cutoff value(r = 0.282, p = 0.012), and Strehl ratio (r = 0.299, p = 0.008).

Conclusions

Our study explored that objective visual quality was correlated with clinical symptoms and signs in DED patients. Furthermore, for the first time, our study explored the relationship between corneal nerves and objective visual quality and discovered that longer and wider corneal nerves were associated with better objective visual quality, which suggested that nerve changes may be a factor that related to poor visual quality in DED patients.

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Title: Evaluation of objective visual quality in dry eye disease and corneal nerve changes
Authors: Jiahui Ma
Shanshan Wei
Xiaodan Jiang
Yilin Chou
Yuexin Wang
Ran Hao
Jiarui Yang
Xuemin Li
Publication date: 01-11-2020
Publisher: Springer Netherlands
Keyword: Xerophthalmia
Published in: International Ophthalmology / Issue 11/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-020-01483-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Evaluation of objective visual quality in dry eye disease and corneal nerve changes

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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