Skip to main content
Top
Published in: Surgical Endoscopy 7/2009

01-07-2009

Why is there recurrence after transcystic laparoscopic bile duct clearance? Risk factor analysis

Authors: A. Bove, G. Bongarzoni, G. Palone, R. M. Di Renzo, E. M. Calisesi, L. Corradetti, M. Di Nicola, L. Corbellini

Published in: Surgical Endoscopy | Issue 7/2009

Login to get access

Abstract

Aim

Incidence of common bile duct stones (CBDS) is approximately 10% in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy. Transcystic laparoscopic common bile duct exploration (TC-CBDE) is safe and efficient in achieving bile duct clearance from stones, with a success rate of between 85% and 95%. The aim of this retrospective study is the evaluation of risk factors and recurrence in patients treated with TC-CBDS.

Methods

From October 2003 until September 2007, 110 consecutive patients with common bile duct stones and gallbladder were included in the study. Average age was 64 years (range 21–82 years). The procedure was completed laparoscopically in 106 patients (96.4%): with TC-CBDE in 90 patients (85%), who are the object of this study; and with TC-CBDE + perioperative guide wire papillotomy (“rendezvous”) in 16 cases (15%). In the 90 patients treated with TC-CBDE which we examined, the risk factors were: preoperative liver function tests, diameter of the common bile duct (normal 8 mm or less), number of stones (≤3 or more), presence of stones with biliary sludge, and pre- or intraoperative diagnosis. Student’s test was used for statistical analysis with a P value of < 0.05 defined as statistically significant.

Result

The conversion rate to open surgery was 3.6%. There were no mortalities. The average operative time was 115.6 min. The morbility rate was 7.7% with 4.8% local complications and 2.9% general complications. Average follow-up on 90 patients (after TC-CBDE) was 28 months (range 4.2–48 months). We found six recurrences (6.7%). The statistic analysis showed that only number of stones >3 with biliary sludge predicted a recurrence (p < 0.05) while the other factors did not show important clinical variables.

Conclusion

TC-CBDE is safe and effective in the majority of cases of CBDS. The incidence of recurrence is low but there are some risk factors, such as number of stones >3 with biliary sludge, which do not favor the successful outcome of the procedure. In such cases, it is essential that the TC-CBDE is integrated with other procedures which, although more complex, assure the clearance of the bile duct.
Literature
1.
go back to reference Collins C, Magauire D, Ireland A, Fitzgerald E, O’Sullivan GC (2004) A prospective study of common bile duct calculi in patients undergoing laparoscopic cholecystectomy: natural history of choledocholithiasis revisited. Ann Surg 239(1):28–33PubMedCrossRef Collins C, Magauire D, Ireland A, Fitzgerald E, O’Sullivan GC (2004) A prospective study of common bile duct calculi in patients undergoing laparoscopic cholecystectomy: natural history of choledocholithiasis revisited. Ann Surg 239(1):28–33PubMedCrossRef
2.
go back to reference Cuschieri A, Lezoche E, Morino M, Croce E, Lacy A, Toouli J, Faggioni A, Ribeiro VM, Jakimowicz J, Visa J, Hanna GB (1999) E.A.E.S. multicenter prospective randomized trial comparing two-stage vs single-stage management of patients with gallstone disease and ductal calculi. Surg Endosc 13(10):952–957PubMedCrossRef Cuschieri A, Lezoche E, Morino M, Croce E, Lacy A, Toouli J, Faggioni A, Ribeiro VM, Jakimowicz J, Visa J, Hanna GB (1999) E.A.E.S. multicenter prospective randomized trial comparing two-stage vs single-stage management of patients with gallstone disease and ductal calculi. Surg Endosc 13(10):952–957PubMedCrossRef
3.
go back to reference Geron N, Reshef R, Shiller M, Kniaz D, Eitan A (1999) The role of endoscopic retrograde cholangiopancreatography in the laparoscopic era. Surg Endosc 13(5):452–456PubMed Geron N, Reshef R, Shiller M, Kniaz D, Eitan A (1999) The role of endoscopic retrograde cholangiopancreatography in the laparoscopic era. Surg Endosc 13(5):452–456PubMed
4.
go back to reference Rhodes M, Sussman L, Cohen L, Lewis MP (1998) Randomised trial of laparoscopic exploration of common bile duct versus postoperative endoscopic retrograde cholangiography for common bile duct stones. Lancet 351(9097):159–161PubMedCrossRef Rhodes M, Sussman L, Cohen L, Lewis MP (1998) Randomised trial of laparoscopic exploration of common bile duct versus postoperative endoscopic retrograde cholangiography for common bile duct stones. Lancet 351(9097):159–161PubMedCrossRef
5.
go back to reference Cervantes J, Rojas G (2001) Choledocholithiasis: new approach to an old problem. World J Surg 25(10):1270–1272PubMedCrossRef Cervantes J, Rojas G (2001) Choledocholithiasis: new approach to an old problem. World J Surg 25(10):1270–1272PubMedCrossRef
6.
go back to reference Karvounis E, Griniatsos J, Arnold J, Atkin G, Isla AM (2006) Why does laparoscopic common bile duct exploration fail? Int Surg 91(2):90–93PubMed Karvounis E, Griniatsos J, Arnold J, Atkin G, Isla AM (2006) Why does laparoscopic common bile duct exploration fail? Int Surg 91(2):90–93PubMed
7.
go back to reference Bove A, Bongarzoni G, Palone G, Di Renzo RM, Calisesi EM, Corbellini L (2006) One stage management of cholecystocholedocholithiasis: a save and effective approach. Hepato-Gastroenterol 53(S1):80–81 Bove A, Bongarzoni G, Palone G, Di Renzo RM, Calisesi EM, Corbellini L (2006) One stage management of cholecystocholedocholithiasis: a save and effective approach. Hepato-Gastroenterol 53(S1):80–81
8.
go back to reference Cuschieri A (2000) Ductal stones: pathology, clinical manifestations, laparoscopic extraction techniques, and complications. Semin Laparosc Surg 7(4):246–261PubMedCrossRef Cuschieri A (2000) Ductal stones: pathology, clinical manifestations, laparoscopic extraction techniques, and complications. Semin Laparosc Surg 7(4):246–261PubMedCrossRef
9.
go back to reference Lauter DM, Froines EJ (2000) Laparoscopic common duct exploration in the management of choledocholithiasis. Am J Surg 179(5):372–374PubMedCrossRef Lauter DM, Froines EJ (2000) Laparoscopic common duct exploration in the management of choledocholithiasis. Am J Surg 179(5):372–374PubMedCrossRef
10.
go back to reference Paganini AM, Guerrieri M, Sarnari J, De Sanctis A, D’Ambrosio G, Lezoche G, Perretta S, Lezoche E (2007) Thirteen years’ experience with laparoscopic transcystic common bile duct exploration for stones. Effectiveness and long-term results. Surg Endosc 21(1):34–40PubMedCrossRef Paganini AM, Guerrieri M, Sarnari J, De Sanctis A, D’Ambrosio G, Lezoche G, Perretta S, Lezoche E (2007) Thirteen years’ experience with laparoscopic transcystic common bile duct exploration for stones. Effectiveness and long-term results. Surg Endosc 21(1):34–40PubMedCrossRef
11.
go back to reference Hirano Y, Tatsuzawa Y, Shimizu J, Kinoshita S, Kawaura Y, Takahashi S (2006) Efficacy of multi-slice computed tomography cholangiography before laparoscopic cholecystectomy. ANZ J Surg 76(8):693–695PubMedCrossRef Hirano Y, Tatsuzawa Y, Shimizu J, Kinoshita S, Kawaura Y, Takahashi S (2006) Efficacy of multi-slice computed tomography cholangiography before laparoscopic cholecystectomy. ANZ J Surg 76(8):693–695PubMedCrossRef
12.
go back to reference Ochiai T, Yamazaki S, Ohta K, Takahashi M, Iwai T, Irie T, Noguchi N, Takamatsu S, Kawamura T, Teramoto K, Arii S (2004) Is drip infusion cholecystocholangiography (DIC) an acceptable modality at cholecystectomy for cholecystolithiasis, considering the frequency of bile duct maljunction and intraoperative bile duct injury? J Hepatobiliary Pancreat Surg 11(2):135–139PubMedCrossRef Ochiai T, Yamazaki S, Ohta K, Takahashi M, Iwai T, Irie T, Noguchi N, Takamatsu S, Kawamura T, Teramoto K, Arii S (2004) Is drip infusion cholecystocholangiography (DIC) an acceptable modality at cholecystectomy for cholecystolithiasis, considering the frequency of bile duct maljunction and intraoperative bile duct injury? J Hepatobiliary Pancreat Surg 11(2):135–139PubMedCrossRef
13.
go back to reference Tranter SE, Thompson MH (2002) Comparison of endoscopic sphincterotomy and laparoscopic exploration of the common bile duct. Br J Surg 89(12):1495–1504PubMedCrossRef Tranter SE, Thompson MH (2002) Comparison of endoscopic sphincterotomy and laparoscopic exploration of the common bile duct. Br J Surg 89(12):1495–1504PubMedCrossRef
14.
go back to reference Schroeppel TJ, Lambert PJ, Mathiason MA, Kothari SN (2007) An economic analysis of hospital charges for choledocholithiasis by different treatment strategies. Am Surg 73(5):472–477PubMed Schroeppel TJ, Lambert PJ, Mathiason MA, Kothari SN (2007) An economic analysis of hospital charges for choledocholithiasis by different treatment strategies. Am Surg 73(5):472–477PubMed
15.
go back to reference Martin DJ, Vernon DR, Toouli J (2006) Surgical versus endoscopic treatment of bile duct stones. Cochrane Database Syst Rev. CD003327, Apr 19, 2006 Martin DJ, Vernon DR, Toouli J (2006) Surgical versus endoscopic treatment of bile duct stones. Cochrane Database Syst Rev. CD003327, Apr 19, 2006
16.
go back to reference Tanaka M, Takahata S, Konomi H, Matsunaga H, Yokohata K, Takeda T, Utsunomiya N, Ikeda S (1998) Long-term consequence of endoscopic sphincterotomy for bile duct stones. Gastrointest Endosc 48(5):465–469PubMedCrossRef Tanaka M, Takahata S, Konomi H, Matsunaga H, Yokohata K, Takeda T, Utsunomiya N, Ikeda S (1998) Long-term consequence of endoscopic sphincterotomy for bile duct stones. Gastrointest Endosc 48(5):465–469PubMedCrossRef
17.
go back to reference Hong DF, Xin Y, Chen DW (2006) Comparison of laparoscopic cholecystectomy combined with intraoperative endoscopic sphincterotomy and laparoscopic exploration of the common bile duct for cholecystocholedocholithiasis. Surg Endosc 20(3):424–427PubMedCrossRef Hong DF, Xin Y, Chen DW (2006) Comparison of laparoscopic cholecystectomy combined with intraoperative endoscopic sphincterotomy and laparoscopic exploration of the common bile duct for cholecystocholedocholithiasis. Surg Endosc 20(3):424–427PubMedCrossRef
18.
go back to reference Rojas-Ortega S, Arizpe-Bravo D, Marín López ER, Cesin-Sánchez R, Roman GR, Gómez C (2003) Transcystic common bile duct exploration in the management of patients with choledocholithiasis. J Gastrointest Surg 7(4):492–496PubMedCrossRef Rojas-Ortega S, Arizpe-Bravo D, Marín López ER, Cesin-Sánchez R, Roman GR, Gómez C (2003) Transcystic common bile duct exploration in the management of patients with choledocholithiasis. J Gastrointest Surg 7(4):492–496PubMedCrossRef
19.
go back to reference Lyass S, Phillips EH (2006) Laparoscopic transcystic duct common bile duct exploration. Surg Endosc 20(Suppl 2):S441–S445PubMedCrossRef Lyass S, Phillips EH (2006) Laparoscopic transcystic duct common bile duct exploration. Surg Endosc 20(Suppl 2):S441–S445PubMedCrossRef
20.
go back to reference Phillips EH, Toouli J, Pitt HA, Soper NJ (2008) Treatment of common bile duct stones discovered during cholecystectomy. J Gastrointest Surg 12(4):624–628PubMedCrossRef Phillips EH, Toouli J, Pitt HA, Soper NJ (2008) Treatment of common bile duct stones discovered during cholecystectomy. J Gastrointest Surg 12(4):624–628PubMedCrossRef
21.
go back to reference Berthou JCh, Dron B, Charbonneau P, Moussalier K, Pellissier L (2007) Evaluation of laparoscopic treatment of common bile duct stones in a prospective series of 505 patients: indications and results. Surg Endosc 21(11):1970–1974PubMedCrossRef Berthou JCh, Dron B, Charbonneau P, Moussalier K, Pellissier L (2007) Evaluation of laparoscopic treatment of common bile duct stones in a prospective series of 505 patients: indications and results. Surg Endosc 21(11):1970–1974PubMedCrossRef
22.
go back to reference Wei Q, Hu HJ, Cai XY, Li LB, Wang GY (2004) Biliary drainage after laparoscopic choledochotomy. World J Gastroenterol 10(21):3175–3178PubMed Wei Q, Hu HJ, Cai XY, Li LB, Wang GY (2004) Biliary drainage after laparoscopic choledochotomy. World J Gastroenterol 10(21):3175–3178PubMed
23.
go back to reference Lezoche E, Paganini AM (2000) Technical considerations and laparoscopic bile duct exploration: transcystic and choledochotomy. Semin Laparosc Surg 7(4):262–278PubMedCrossRef Lezoche E, Paganini AM (2000) Technical considerations and laparoscopic bile duct exploration: transcystic and choledochotomy. Semin Laparosc Surg 7(4):262–278PubMedCrossRef
24.
go back to reference Carroll BJ, Phillips EH, Rosenthal R, Liberman M, Fallas M (1996) Update on transcystic exploration of the bile duct. Surg Laparosc Endosc 6(6):453–458PubMedCrossRef Carroll BJ, Phillips EH, Rosenthal R, Liberman M, Fallas M (1996) Update on transcystic exploration of the bile duct. Surg Laparosc Endosc 6(6):453–458PubMedCrossRef
25.
go back to reference Strömberg C, Nilsson M, Leijonmarck CE (2008) Stone clearance and risk factors for failure in laparoscopic transcystic exploration of the common bile duct. Surg Endosc 22(5):1194–1199 Strömberg C, Nilsson M, Leijonmarck CE (2008) Stone clearance and risk factors for failure in laparoscopic transcystic exploration of the common bile duct. Surg Endosc 22(5):1194–1199
26.
go back to reference Hemli JM, Arnot RS, Ashworth JJ, Curtin AM, Simon RA, Townend DM (2004) Feasibility of laparoscopic common bile duct exploration in a rural centre. ANZ J Surg 74(11):979–982PubMedCrossRef Hemli JM, Arnot RS, Ashworth JJ, Curtin AM, Simon RA, Townend DM (2004) Feasibility of laparoscopic common bile duct exploration in a rural centre. ANZ J Surg 74(11):979–982PubMedCrossRef
27.
go back to reference Topal B, Aerts R, Penninckx F (2007) Laparoscopic common bile duct stone clearance with flexible choledochoscopy. Surg Endosc 21:2317–2321PubMedCrossRef Topal B, Aerts R, Penninckx F (2007) Laparoscopic common bile duct stone clearance with flexible choledochoscopy. Surg Endosc 21:2317–2321PubMedCrossRef
28.
go back to reference Tinoco R, Tinoco A, El-Kadre L, Peres L, Sueth D (2008) Laparoscopic common bile duct exploration. Ann Surg 247(4):674–679PubMedCrossRef Tinoco R, Tinoco A, El-Kadre L, Peres L, Sueth D (2008) Laparoscopic common bile duct exploration. Ann Surg 247(4):674–679PubMedCrossRef
29.
go back to reference Lien HH, Huang CC, Huang CS, Shi MY, Chen DF, Wang NY, Tai FC (2005) Laparoscopic common bile duct exploration with T-tube choledochotomy for the management of choledocholithiasis. J Laparoendosc Adv Surg Tech A 15(3):298–302PubMedCrossRef Lien HH, Huang CC, Huang CS, Shi MY, Chen DF, Wang NY, Tai FC (2005) Laparoscopic common bile duct exploration with T-tube choledochotomy for the management of choledocholithiasis. J Laparoendosc Adv Surg Tech A 15(3):298–302PubMedCrossRef
30.
go back to reference Morino M, Baracchi F, Miglietta C, Furlan N, Ragona R, Garbarini A (2006) Preoperative endoscopic sphincterotomy versus laparoendoscopic rendezvous in patients with gallbladder and bile duct stones. Ann Surg Dec 244(6):889–893; discussion 893–896 Morino M, Baracchi F, Miglietta C, Furlan N, Ragona R, Garbarini A (2006) Preoperative endoscopic sphincterotomy versus laparoendoscopic rendezvous in patients with gallbladder and bile duct stones. Ann Surg Dec 244(6):889–893; discussion 893–896
31.
go back to reference Urbach DR, Khajanchee YS, Jobe BA, Standage BA, Hansen PD, Swanstrom LL (2001) Cost-effective management of common bile duct stones: a decision analysis of the use of endoscopic retrograde cholangiopancreatography (ERCP), intraoperative cholangiography, and laparoscopic bile duct exploration. Surg Endosc 15(1):4–13PubMedCrossRef Urbach DR, Khajanchee YS, Jobe BA, Standage BA, Hansen PD, Swanstrom LL (2001) Cost-effective management of common bile duct stones: a decision analysis of the use of endoscopic retrograde cholangiopancreatography (ERCP), intraoperative cholangiography, and laparoscopic bile duct exploration. Surg Endosc 15(1):4–13PubMedCrossRef
32.
go back to reference Riciardi R, Islam S, Canete JJ, Arcand PL, Stoker ME (2003) Effective and long-term results of laparoscopic common bile duct exploration. Surg Endosc 17:19–22PubMedCrossRef Riciardi R, Islam S, Canete JJ, Arcand PL, Stoker ME (2003) Effective and long-term results of laparoscopic common bile duct exploration. Surg Endosc 17:19–22PubMedCrossRef
Metadata
Title
Why is there recurrence after transcystic laparoscopic bile duct clearance? Risk factor analysis
Authors
A. Bove
G. Bongarzoni
G. Palone
R. M. Di Renzo
E. M. Calisesi
L. Corradetti
M. Di Nicola
L. Corbellini
Publication date
01-07-2009
Publisher
Springer-Verlag
Published in
Surgical Endoscopy / Issue 7/2009
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-009-0377-7

Other articles of this Issue 7/2009

Surgical Endoscopy 7/2009 Go to the issue