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01-12-2020 | Letter

Who may benefit most from future vitamin D intervention trials: do not forget patients on continuous renal replacement therapy

Authors: Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Published in: Critical Care | Issue 1/2020

Excerpt

We read with great interest the recent paper by Martucci et al. who concluded that high-dose vitamin D3 supplementation was associated with a reduction in 28-day mortality in a mixed population of critically ill adults with vitamin D deficiency [1]. Their analysis also attempted to identify who may benefit the most from future vitamin D intervention trials [1]. We would like to make some comments. In their paper, Martucci et al. did not include data regarding patients with acute kidney injury (AKI) needing renal replacement therapy (RRT) within the critically ill population they studied [1]. …

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Honoré PM, De Waele E, Jacobs R, Mattens S, Rose T, Joannes-Boyau O, De Regt J, Verfaillie L, Van Gorp V, Boer W, Collin V, Spapen HD. Nutritional and metabolic alterations during continuous renal replacement therapy. Blood Purif. 2013;35(4):279–84. https://doi.org/10.1159/000350610 Epub 2013 May 8. Review..CrossRefPubMed

Honoré PM, De Bels D, Spapen HD. An update on membranes and cartridges for extracorporeal blood purification in sepsis and septic shock. Curr Opin Crit Care. 2018;24(6):463–8. https://doi.org/10.1097/MCC.0000000000000542 Review..CrossRefPubMed

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Amrein K, Parekh D, Westphal S, Preiser JC, Berghold A, Riedl R, Eller P, Schellongowski P, Thickett D, Meybohm P. Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a study protocol of a multicentre, placebo-controlled double-blind phase III RCT (the VITDALIZE study). BMJ Open. 2019;9(11):e031083..CrossRef

Title: Who may benefit most from future vitamin D intervention trials: do not forget patients on continuous renal replacement therapy
Authors: Patrick M. Honore
Aude Mugisha
Luc Kugener
Sebastien Redant
Rachid Attou
Andrea Gallerani
David De Bels
Publication date: 01-12-2020
Publisher: BioMed Central
Published in: Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-020-02910-w

At a glance: The STEP trials

Springer Medicine

Who may benefit most from future vitamin D intervention trials: do not forget patients on continuous renal replacement therapy

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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