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European Radiology
Published in: European Radiology 7/2016

01-07-2016 | Neuro

White matter integrity associated with clinical symptoms in tinnitus patients: A tract-based spatial statistics study

Authors: Chang-Woo Ryu, Moon Suh Park, Jae Yong Byun, Geon-Ho Jahng, Soonchan Park

Published in: European Radiology | Issue 7/2016

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Abstract

Objective

To assess the relationship between white matter (WM) integrity and clinical variables in tinnitus patients using diffusion tensor imaging (DTI).

Methods

Sixty-seven tinnitus patients and 39 healthy controls were enrolled in this study. The tinnitus duration, laterality, pitch and characteristics, and two psychological self-rating tests were used as independent variables. Differences between patients and controls in diffusion indices were evaluated using tract-based spatial statistics (TBSS), and multiple regression between DTI values in significant clusters and clinical variables was investigated. TBSS correlation analysis between the clinical variables and DTI indices was performed in tinnitus patients.

Results

The tinnitus group had higher mean diffusivity (MD) and axial diffusivity in WM under the auditory cortex and limbic system compared with control group. Depression symptom score (BDI) was the only significant variable affecting MD and axial diffusivity value in these clusters. TBSS correlation analysis with BDI in tinnitus patients showed BDI was associated with diffusion indices in widespread regions of WM.

Conclusions

WM integrity in tinnitus was associated with depression symptoms in both inter- and intragroup analyses. Our results support the hypothesized implication of altered WM integrity in the physiopathology of emotional symptoms of tinnitus.

Key Points

• WM integrity of left auditory-limbic circuit in tinnitus is different in controls.
• Depression symptoms are a significant clinical variable affecting DTI values.
• DTI value is correlated with depression symptoms in tinnitus patients.
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Metadata
Title
White matter integrity associated with clinical symptoms in tinnitus patients: A tract-based spatial statistics study
Authors
Chang-Woo Ryu
Moon Suh Park
Jae Yong Byun
Geon-Ho Jahng
Soonchan Park
Publication date
01-07-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 7/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-4034-3

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