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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2014

Open Access 01-12-2014 | Research

Which tinnitus-related aspects are relevant for quality of life and depression: results from a large international multicentre sample

Authors: Florian Zeman, Michael Koller, Berthold Langguth, Michael Landgrebe, Tinnitus Research Initiative database study group

Published in: Health and Quality of Life Outcomes | Issue 1/2014

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Abstract

Background

The aim of the present study was to investigate, which aspects of tinnitus are most relevant for impairment of quality of life. For this purpose we analysed how responses to the Tinnitus Handicap Inventory (THI) and to the question “How much of a problem is your tinnitus at present” correlate with the different aspects of quality of life and depression.

Methods

1274 patients of the Tinnitus Research Initiative database were eligible for analysis. The Tinnitus Research Initiative database is composed of eight study centres from five countries. We assessed to which extent the Tinnitus Handicap Inventory (THI) and its subscales and single items as well as the tinnitus severity correlate with Beck Depression Inventory (BDI) score and different domains of the short version of the WHO-Quality of Life questionnaire (WHO-QoL Bref) by means of simple and multiple linear regression models.

Results

The THI explained considerable portions of the variance of the WHO-QoL Physical Health (R2 = 0.39) and Psychological Health (R2 = 0.40) and the BDI (R2 = 0.46). Furthermore, multiple linear regression models which included each THI item separately explained an additional 5% of the variance compared to the THI total score. The items feeling confused from tinnitus, the trouble of falling asleep at night, the interference with job or household responsibilities, getting upset from tinnitus, and the feeling of being depressed were those with the highest influence on quality of life and depression. The single question with regard to tinnitus severity explained 18%, 16%, and 20% of the variance of Physical Health, Psychological Health, and BDI respectively.

Conclusions

In the context of a cross-sectional correlation analysis, our findings confirmed the strong and consistent relationships between self-reported tinnitus burden and both quality of life, and depression. The single question “How much of a problem is your tinnitus” reflects tinnitus-related impairment in quality of life and can thus be recommended for use in clinical routine.
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Literature
1.
Møller AR, Langguth B, DeRidder D, Kleinjung T: Textbook of Tinnitus: Diagnosis and Treatment. 1st edition. New York: Springer; 2010:786.
2.
Langguth B, Kleinjung T, Landgrebe M: Tinnitus: the complexity of standardization. Eval Health Prof 2011, 34: 429–433. 10.1177/0163278710394337CrossRefPubMed
3.
4.
Langguth B, Goodey R, Azevedo A, Bjorne A, Cacace A, Crocetti A, Del Bo L, De Ridder D, Diges I, Elbert T, Flor H, Herraiz C, Ganz Sanchez T, Eichhammer P, Figueiredo R, Hajak G, Kleinjung T, Landgrebe M, Londero A, Lainez MJA, Mazzoli M, Meikle MB, Melcher J, Rauschecker JP, Sand PG, Struve M, Van de Heyning P, Van Dijk P, Vergara R: Consensus for tinnitus patient assessment and treatment outcome measurement: Tinnitus Research Initiative meeting, Regensburg, July 2006. Prog Brain Res 2007, 166: 525–536.PubMedCentralCrossRefPubMed
5.
Nondahl DM, Cruickshanks KJ, Dalton DS, Klein BEK, Klein R, Schubert CR, Tweed TS, Wiley TL: The impact of tinnitus on quality of life in older adults. J Am Acad Audiol 2007, 18: 257–266. 10.3766/jaaa.18.3.7CrossRefPubMed
6.
Monzani D, Genovese E, Marrara A, Gherpelli C, Pingani L, Forghieri M, Rigatelli M, Guadagnin T, Arslan E: Validity of the Italian adaptation of the Tinnitus Handicap Inventory; focus on quality of life and psychological distress in tinnitus-sufferers. Acta Otorhinolaryngol Ital 2008, 28: 126–134.PubMedCentralPubMed
7.
Bartels H, Middel BL, Van der Laan BFAM, Staal MJ, Albers FWJ: The additive effect of co-occurring anxiety and depression on health status, quality of life and coping strategies in help-seeking tinnitus sufferers. Ear Hear 2008, 29: 947–956. 10.1097/AUD.0b013e3181888f83CrossRefPubMed
8.
Muluk NB, Oguztürk O: Occupational noise-induced tinnitus: does it affect workers’ quality of life? J Otolaryngol - Head Neck Surg 2008, 37: 65–71.PubMed
9.
Gopinath B, McMahon CM, Rochtchina E, Karpa MJ, Mitchell P: Risk factors and impacts of incident tinnitus in older adults. Ann Epidemiol 2010, 20: 129–135. 10.1016/j.annepidem.2009.09.002CrossRefPubMed
10.
Lasisi AO, Gureje O: Prevalence of insomnia and impact on quality of life among community elderly subjects with tinnitus. Ann Otol Rhinol Laryngol 2011, 120: 226–230.PubMedCentralCrossRefPubMed
11.
Bauch CD, Lynn SG, Williams DE, Mellon MW, Weaver AL: Tinnitus impact: three different measurement tools. J Am Acad Audiol 2003, 14: 181–187.PubMed
12.
Crönlein T, Langguth B, Geisler P, Hajak G: Tinnitus and insomnia. Prog Brain Res 2007, 166: 227–233.CrossRefPubMed
13.
Meikle MB, Vernon J, Johnson RM: The perceived severity of tinnitus. Some observations concerning a large population of tinnitus clinic patients. Otolaryngol Neck Surg 1984, 92: 689–696.
14.
Landgrebe M, Zeman F, Koller M, Eberl Y, Mohr M, Reiter J, Staudinger S, Hajak G, Langguth B: The Tinnitus Research Initiative (TRI) database: a new approach for delineation of tinnitus subtypes and generation of predictors for treatment outcome. BMC Med Inform Decis Mak 2010, 10: 42. 10.1186/1472-6947-10-42PubMedCentralCrossRefPubMed
15.
Zeman F, Koller M, Schecklmann M, Langguth B, Landgrebe M: Tinnitus assessment by means of standardized self-report questionnaires: psychometric properties of the Tinnitus Questionnaire (TQ), the Tinnitus Handicap Inventory (THI), and their short versions in an international and multi-lingual sample. Health Qual Life Outcomes 2012, 10: 128. 10.1186/1477-7525-10-128PubMedCentralCrossRefPubMed
16.
Newman CW, Jacobson GP, Spitzer JB: Development of the Tinnitus Handicap Inventory. Arch Otolaryngol Head Neck Surg 1996, 122: 143–148. 10.1001/archotol.1996.01890140029007CrossRefPubMed
17.
Baguley DM, Andersson G: Factor analysis of the Tinnitus Handicap Inventory. Am J Audiol 2003, 12: 31–34. 10.1044/1059-0889(2003/007)CrossRefPubMed
18.
Meikle MB, Henry JA, Griest SE, Stewart BJ, Abrams HB, McArdle R, Myers PJ, Newman CW, Sandridge S, Turk DC, Folmer RL, Frederick EJ, House JW, Jacobson GP, Kinney SE, Martin WH, Nagler SM, Reich GE, Searchfield G, Sweetow R, Vernon JA: The tinnitus functional index: development of a new clinical measure for chronic, intrusive tinnitus. Ear Hear 2012, 33: 153–176. 10.1097/AUD.0b013e31822f67c0CrossRefPubMed
19.
Skevington SM, Lotfy M, O’Connell KA: The World Health Organization’s WHOQOL-BREF quality of life assessment: psychometric properties and results of the international field trial. A report from the WHOQOL group. Qual Life Res 2004, 13: 299–310.CrossRefPubMed
20.
Beck AT, Rush JA, Shaw BF, Emery G: Cognitive Therapy of Depression. 1st edition. New York: The Guilford Press; 1979.
21.
Ooms E, Meganck R, Vanheule S, Vinck B, Watelet J-B, Dhooge I: Tinnitus severity and the relation to depressive symptoms: a critical study. Otolaryngol Neck Surg 2011, 145: 276–281. 10.1177/0194599811403381CrossRef
22.
Vanneste S, To WT, De Ridder D: The psychometric properties of the Tinnitus Handicap Questionnaire in a Dutch-speaking population. Clin Otolaryngol 2011, 36: 9–16. 10.1111/j.1749-4486.2010.02256.xCrossRefPubMed
23.
Crocetti A, Forti S, Ambrosetti U, Del Bo L: Questionnaires to evaluate anxiety and depressive levels in tinnitus patients. Otolaryngol Neck Surg 2009, 140: 403–405. 10.1016/j.otohns.2008.11.036CrossRef
24.
Milerová J, Anders M, Dvořák T, Sand PG, Königer S, Langguth B: The influence of psychological factors on tinnitus severity. Gen Hosp Psychiatry 2013, 35(4):412–416. 10.1016/j.genhosppsych.2013.02.008CrossRefPubMed
25.
Langguth B, Kleinjung T, Landgrebe M: Severe tinnitus and depressive symptoms: a complex interaction. Otolaryngol Neck Surg 2011, 145: 519. author reply 520 10.1177/0194599811411851CrossRef
26.
Langguth B, Landgrebe M, Kleinjung T, Sand GP, Hajak G: Tinnitus and depression. World J Biol Psychiatryy 2011, 12: 489–500. 10.3109/15622975.2011.575178CrossRef
27.
Hébert S, Canlon B, Hasson D, Magnusson Hanson LL, Westerlund H, Theorell T: Tinnitus severity is reduced with reduction of depressive mood--a prospective population study in Sweden. PLoS One 2012, 7: e37733. 10.1371/journal.pone.0037733PubMedCentralCrossRefPubMed
28.
Langguth B, Kleinjung T, Fischer B, Hajak G, Eichhammer P, Sand PG: Tinnitus severity, depression, and the big five personality traits. Prog Brain Res 2007, 166: 221–5.CrossRefPubMed
29.
Bankstahl US, Elkin EP, Gebauer A, Görtelmeyer R: Validation of the THI-12 questionnaire for international use in assessing tinnitus: a multi-centre, prospective, observational study. Int J Audiol 2012, 51: 671–7. 10.3109/14992027.2011.653448CrossRefPubMed
30.
Biesinger E, Heiden C, Greimel V, Lendle T, Höing R, Albegger K: Strategies in ambulatory treatment of tinnitus. HNO 1998, 46: 157–69. 10.1007/s001060050215CrossRefPubMed
31.
Schwarz N: What respondents learn from scales: the informative functions of response alternatives. Int J Public Opin Res 1990, 2: 274–285. 10.1093/ijpor/2.3.274CrossRef
32.
Schwarz N, Strack F: Subjective Well-Being: an interdisciplinary perspective. In Evaluating one’s life: a judgement model of subjective well-being. Edited by: Strack F, Argyle M, Schwarz N. Oxford: Oxford University Press; 1991:27–47.
33.
Schwarz N, Strack F, Müller G, Chassein B: The range of response alternatives May determine the meaning of the question: further evidence on informative functions of response alternatives. Soc Cogn 1988, 6: 107–117. 10.1521/soco.1988.6.2.107CrossRef
Metadata
Title
Which tinnitus-related aspects are relevant for quality of life and depression: results from a large international multicentre sample
Authors
Florian Zeman
Michael Koller
Berthold Langguth
Michael Landgrebe
Tinnitus Research Initiative database study group
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2014
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-12-7

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