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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2018

Open Access 01-12-2018 | Research

Whether vitamin D was associated with clinical outcome after IVF/ICSI: a systematic review and meta-analysis

Authors: Jing Zhao, Xi Huang, Bin Xu, Yi Yan, Qiong Zhang, Yanping Li

Published in: Reproductive Biology and Endocrinology | Issue 1/2018

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Abstract

Background

There exist contradictive views on whether the vitamin D has association with clinical outcome of in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI). The present meta-analysis aim to establish whether vitamin D was associated with clinical outcomes of IVF/ICSI.

Methods

MEDLINE, Google Scholar and the Cochrane Library from database inception to March 2017 were searched. Clinical studies, which evaluated the association of vitamin D level and the clinical outcomes after IVF/ICSI, were included. The Main Outcome Measures were clinical pregnancy, ongoing pregnancy, and live birth.

Results

In the analysis of clinical pregnancy, 9 cohort studies were included. Of which, 2 studies and 3 studies were identified in analyzing ongoing pregnancy and live birth, respectively. Meta-analysis showed trends toward lower clinical pregnancy [RR 0.91, (95% CI 0.77–1.07)] and higher ongoing pregnancy [RR 1.06, (95% CI 0.95–1.19)] for women with deficient level of vitamin D. The probability of live birth for women with deficient level of vitamin D was significantly lower than cases with sufficient level of vitamin D [RR 0.74, (95% CI 0.58–0.90)].

Conclusions

Deficient vitamin D was associated with decreased probability of live birth after IVF/ICSI. So vitamin D should be supplied to women with deficient level vitamin D.
Appendix
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Metadata
Title
Whether vitamin D was associated with clinical outcome after IVF/ICSI: a systematic review and meta-analysis
Authors
Jing Zhao
Xi Huang
Bin Xu
Yi Yan
Qiong Zhang
Yanping Li
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2018
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-018-0324-3

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