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Open Access 01-12-2007 | Review

What’s new in using platelet research? To unravel thrombopathies and other human disorders

Authors: Kathleen Freson, Veerle Labarque, Chantal Thys, Christine Wittevrongel, Chris Van Geet

Published in: European Journal of Pediatrics | Issue 12/2007

Abstract

This review on platelet research focuses on defects of adhesion, cytoskeletal organisation, signal transduction and secretion. Platelet defects can be studied by different laboratory platelet functional assays and morphological studies. Easy bruising or a suspected platelet-based bleeding disorder is of course the most obvious reason to test the platelet function in a patient. However, nowadays platelet research also contributes to our understanding of human pathology in other disciplines such as neurology, nephrology, endocrinology and metabolic diseases. Apart from a discussion on classical thrombopathies, this review will also deal with the less commonly known relation between platelet research and disorders with a broader clinical phenotype. Classical thrombopathies involve disorders of platelet adhesion such as Glanzmann thrombastenia and Bernard-Soulier syndrome, defective G protein signalling diseases with impaired phospholipase C activation, and abnormal platelet granule secretion disorders such as gray platelet disorder and delta-storage pool disease. Other clinical symptoms besides a bleeding tendency have been described in MYH9-related disorders and Duchenne muscular dystrophy due to adhesion defects, and also in disorders of impaired Gs signalling, in Hermansky Pudlack disease and Chediak Higashi disease with abnormal secretion. Finally, platelet research can also be used to unravel novel mechanisms involved in many neurological disorders such as depression and autism with only a subclinical platelet defect.

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Title: What’s new in using platelet research? To unravel thrombopathies and other human disorders
Authors: Kathleen Freson
Veerle Labarque
Chantal Thys
Christine Wittevrongel
Chris Van Geet
Publication date: 01-12-2007
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 12/2007
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-007-0543-7

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What’s new in using platelet research? To unravel thrombopathies and other human disorders

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