Published in:
01-03-2015 | What's New in Intensive Care
What’s new in perioperative renal dysfunction?
Authors:
Johan Mårtensson, R. Bellomo
Published in:
Intensive Care Medicine
|
Issue 3/2015
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Excerpt
The increasing incidence of acute kidney injury (AKI) is approaching epidemic status worldwide. Moreover, AKI-associated mortality remains high. More people die with AKI than from breast cancer, prostate cancer, heart failure and diabetes combined [
1]. In addition, the development of chronic and end-stage kidney disease and cardiovascular morbidity are now recognised as long-term consequences of the AKI syndrome [
2]. After sepsis, major surgery is the most common AKI-trigger. However, the mechanisms responsible for postoperative AKI remain poorly defined. Thus, perioperative AKI is an area of intense research. In particular, potential biomarkers of early tubular stress as well as promising therapies to prevent and ameliorate AKI are under active investigation. …