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Published in: Intensive Care Medicine 3/2015

01-03-2015 | What's New in Intensive Care

What’s new in perioperative renal dysfunction?

Authors: Johan Mårtensson, R. Bellomo

Published in: Intensive Care Medicine | Issue 3/2015

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Excerpt

The increasing incidence of acute kidney injury (AKI) is approaching epidemic status worldwide. Moreover, AKI-associated mortality remains high. More people die with AKI than from breast cancer, prostate cancer, heart failure and diabetes combined [1]. In addition, the development of chronic and end-stage kidney disease and cardiovascular morbidity are now recognised as long-term consequences of the AKI syndrome [2]. After sepsis, major surgery is the most common AKI-trigger. However, the mechanisms responsible for postoperative AKI remain poorly defined. Thus, perioperative AKI is an area of intense research. In particular, potential biomarkers of early tubular stress as well as promising therapies to prevent and ameliorate AKI are under active investigation. …
Literature
1.
2.
go back to reference Chawla LS, Eggers PW, Star RA, Kimmel PL (2014) Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med 371:58–66CrossRefPubMed Chawla LS, Eggers PW, Star RA, Kimmel PL (2014) Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med 371:58–66CrossRefPubMed
3.
go back to reference Masoomi H, Carmichael JC, Dolich M, Mills S, Ketana N, Pigazzi A, Stamos MJ (2012) Predictive factors of acute renal failure in colon and rectal surgery. Am Surg 78:1019–1023PubMed Masoomi H, Carmichael JC, Dolich M, Mills S, Ketana N, Pigazzi A, Stamos MJ (2012) Predictive factors of acute renal failure in colon and rectal surgery. Am Surg 78:1019–1023PubMed
4.
go back to reference Martines AM, Masereeuw R, Tjalsma H, Hoenderop JG, Wetzels JF, Swinkels DW (2013) Iron metabolism in the pathogenesis of iron-induced kidney injury. Nat Rev Nephrol 9:385–398CrossRefPubMed Martines AM, Masereeuw R, Tjalsma H, Hoenderop JG, Wetzels JF, Swinkels DW (2013) Iron metabolism in the pathogenesis of iron-induced kidney injury. Nat Rev Nephrol 9:385–398CrossRefPubMed
5.
go back to reference Meersch M, Schmidt C, Van Aken H, Martens S, Rossaint J, Singbartl K, Gorlich D, Kellum JA, Zarbock A (2014) Urinary TIMP-2 and IGFBP7 as early biomarkers of acute kidney injury and renal recovery following cardiac surgery. PLoS One 9:e93460CrossRefPubMedCentralPubMed Meersch M, Schmidt C, Van Aken H, Martens S, Rossaint J, Singbartl K, Gorlich D, Kellum JA, Zarbock A (2014) Urinary TIMP-2 and IGFBP7 as early biomarkers of acute kidney injury and renal recovery following cardiac surgery. PLoS One 9:e93460CrossRefPubMedCentralPubMed
6.
go back to reference Liu S, Che M, Xue S, Xie B, Zhu M, Lu R, Zhang W, Qian J, Yan Y (2013) Urinary L-FABP and its combination with urinary NGAL in early diagnosis of acute kidney injury after cardiac surgery in adult patients. Biomarkers 18:95–101CrossRefPubMed Liu S, Che M, Xue S, Xie B, Zhu M, Lu R, Zhang W, Qian J, Yan Y (2013) Urinary L-FABP and its combination with urinary NGAL in early diagnosis of acute kidney injury after cardiac surgery in adult patients. Biomarkers 18:95–101CrossRefPubMed
7.
go back to reference Arthur JM, Hill EG, Alge JL, Lewis EC, Neely BA, Janech MG, Tumlin JA, Chawla LS, Shaw AD (2014) Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgery. Kidney Int 85:431–438CrossRefPubMedCentralPubMed Arthur JM, Hill EG, Alge JL, Lewis EC, Neely BA, Janech MG, Tumlin JA, Chawla LS, Shaw AD (2014) Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgery. Kidney Int 85:431–438CrossRefPubMedCentralPubMed
8.
go back to reference Walsh M, Devereaux PJ, Garg AX, Kurz A, Turan A, Rodseth RN, Cywinski J, Thabane L, Sessler DI (2013) Relationship between intraoperative mean arterial pressure and clinical outcomes after noncardiac surgery: toward an empirical definition of hypotension. Anesthesiology 119:507–515CrossRefPubMed Walsh M, Devereaux PJ, Garg AX, Kurz A, Turan A, Rodseth RN, Cywinski J, Thabane L, Sessler DI (2013) Relationship between intraoperative mean arterial pressure and clinical outcomes after noncardiac surgery: toward an empirical definition of hypotension. Anesthesiology 119:507–515CrossRefPubMed
9.
go back to reference Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, Mira JP, Dequin PF, Gergaud S, Weiss N, Legay F, Le Tulzo Y, Conrad M, Robert R, Gonzalez F, Guitton C, Tamion F, Tonnelier JM, Guezennec P, Van Der Linden T, Vieillard-Baron A, Mariotte E, Pradel G, Lesieur O, Ricard JD, Herve F, du Cheyron D, Guerin C, Mercat A, Teboul JL, Radermacher P (2014) High versus low blood-pressure target in patients with septic shock. N Engl J Med 370:1583–1593CrossRefPubMed Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, Mira JP, Dequin PF, Gergaud S, Weiss N, Legay F, Le Tulzo Y, Conrad M, Robert R, Gonzalez F, Guitton C, Tamion F, Tonnelier JM, Guezennec P, Van Der Linden T, Vieillard-Baron A, Mariotte E, Pradel G, Lesieur O, Ricard JD, Herve F, du Cheyron D, Guerin C, Mercat A, Teboul JL, Radermacher P (2014) High versus low blood-pressure target in patients with septic shock. N Engl J Med 370:1583–1593CrossRefPubMed
10.
go back to reference Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP, Ahern A, Griggs K, Scott R, Hinds C, Rowan K (2014) Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA 311:2181–2190CrossRefPubMed Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP, Ahern A, Griggs K, Scott R, Hinds C, Rowan K (2014) Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA 311:2181–2190CrossRefPubMed
11.
go back to reference Prowle JR, Kirwan CJ, Bellomo R (2014) Fluid management for the prevention and attenuation of acute kidney injury. Nat Rev Nephrol 10:37–47CrossRefPubMed Prowle JR, Kirwan CJ, Bellomo R (2014) Fluid management for the prevention and attenuation of acute kidney injury. Nat Rev Nephrol 10:37–47CrossRefPubMed
12.
go back to reference Kashy BK, Podolyak A, Makarova N, Dalton JE, Sessler DI, Kurz A (2014) Effect of hydroxyethyl starch on postoperative kidney function in patients having noncardiac surgery. Anesthesiology 121:730–739CrossRefPubMed Kashy BK, Podolyak A, Makarova N, Dalton JE, Sessler DI, Kurz A (2014) Effect of hydroxyethyl starch on postoperative kidney function in patients having noncardiac surgery. Anesthesiology 121:730–739CrossRefPubMed
13.
go back to reference Shaw AD, Bagshaw SM, Goldstein SL, Scherer LA, Duan M, Schermer CR, Kellum JA (2012) Major complications, mortality, and resource utilization after open abdominal surgery: 0.9% saline compared to Plasma-Lyte. Ann Surg 255:821–829CrossRefPubMed Shaw AD, Bagshaw SM, Goldstein SL, Scherer LA, Duan M, Schermer CR, Kellum JA (2012) Major complications, mortality, and resource utilization after open abdominal surgery: 0.9% saline compared to Plasma-Lyte. Ann Surg 255:821–829CrossRefPubMed
14.
go back to reference Nigwekar SU, Navaneethan SD, Parikh CR, Hix JK (2009) Atrial natriuretic peptide for management of acute kidney injury: a systematic review and meta-analysis. Clin J Am Soc Nephrol 4:261–272CrossRefPubMedCentralPubMed Nigwekar SU, Navaneethan SD, Parikh CR, Hix JK (2009) Atrial natriuretic peptide for management of acute kidney injury: a systematic review and meta-analysis. Clin J Am Soc Nephrol 4:261–272CrossRefPubMedCentralPubMed
15.
go back to reference Bove T, Zangrillo A, Guarracino F, Alvaro G, Persi B, Maglioni E, Galdieri N, Comis M, Caramelli F, Pasero DC, Pala G, Renzini M, Conte M, Paternoster G, Martinez B, Pinelli F, Frontini M, Zucchetti MC, Pappalardo F, Amantea B, Camata A, Pisano A, Verdecchia C, Dal Checco E, Cariello C, Faita L, Baldassarri R, Scandroglio AM, Saleh O, Lembo R, Calabro MG, Bellomo R, Landoni G (2014) Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial. JAMA 312(21). doi:10.1001/jama.2014.13573 PubMed Bove T, Zangrillo A, Guarracino F, Alvaro G, Persi B, Maglioni E, Galdieri N, Comis M, Caramelli F, Pasero DC, Pala G, Renzini M, Conte M, Paternoster G, Martinez B, Pinelli F, Frontini M, Zucchetti MC, Pappalardo F, Amantea B, Camata A, Pisano A, Verdecchia C, Dal Checco E, Cariello C, Faita L, Baldassarri R, Scandroglio AM, Saleh O, Lembo R, Calabro MG, Bellomo R, Landoni G (2014) Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial. JAMA 312(21). doi:10.​1001/​jama.​2014.​13573 PubMed
Metadata
Title
What’s new in perioperative renal dysfunction?
Authors
Johan Mårtensson
R. Bellomo
Publication date
01-03-2015
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 3/2015
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-014-3596-x

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