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Published in: Trials 1/2014

Open Access 01-12-2014 | Study protocol

What is the ideal dose and power output of low-level laser therapy (810 nm) on muscle performance and post-exercise recovery? Study protocol for a double-blind, randomized, placebo-controlled trial

Authors: Adriano Rodrigues de Oliveira, Adriane Aver Vanin, Thiago De Marchi, Fernanda Colella Antonialli, Vanessa dos Santos Grandinetti, Paulo Roberto Vicente de Paiva, Gianna Móes Albuquerque Pontes, Larissa Aline Santos, Ivo de Oliveira Aleixo Junior, Paulo de Tarso Camillo de Carvalho, Jan Magnus Bjordal, Ernesto Cesar Pinto Leal-Junior

Published in: Trials | Issue 1/2014

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Abstract

Background

Recent studies involving phototherapy applied prior to exercise have demonstrated positive results regarding the attenuation of muscle fatigue and the expression of biochemical markers associated with recovery. However, a number of factors remain unknown, such as the ideal dose and application parameters, mechanisms of action and long-term effects on muscle recovery. The aims of the proposed project are to evaluate the long-term effects of low-level laser therapy on post-exercise musculoskeletal recovery and identify the best dose andapplication power/irradiation time.

Design and methods

A double-blind, randomized, placebo-controlled clinical trial with be conducted. After fulfilling the eligibility criteria, 28 high-performance athletes will be allocated to four groups of seven volunteers each. In phase 1, the laser power will be 200 mW and different doses will be tested: Group A (2 J), Group B (6 J), Group C (10 J) and Group D (0 J). In phase 2, the best dose obtained in phase 1 will be used with the same distribution of the volunteers, but with different powers: Group A (100 mW), Group B (200 mW), Group C (400 mW) and Group D (0 mW). The isokinetic test will be performed based on maximum voluntary contraction prior to the application of the laser and after the eccentric contraction protocol, which will also be performed using the isokinetic dynamometer. The following variables related to physical performance will be analyzed: peak torque/maximum voluntary contraction, delayed onset muscle soreness (algometer), biochemical markers of muscle damage, inflammation and oxidative stress.

Discussion

Our intention, is to determine optimal laser therapy application parameters capable of slowing down the physiological muscle fatigue process, reducing injuries or micro-injuries in skeletal muscle stemming from physical exertion and accelerating post-exercise muscle recovery. We believe that, unlike drug therapy, LLLT has a biphasic dose–response pattern.

Trial registration

The protocol for this study is registered with the Protocol Registry System, ClinicalTrials.gov identifier NCT01844271.
Appendix
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Metadata
Title
What is the ideal dose and power output of low-level laser therapy (810 nm) on muscle performance and post-exercise recovery? Study protocol for a double-blind, randomized, placebo-controlled trial
Authors
Adriano Rodrigues de Oliveira
Adriane Aver Vanin
Thiago De Marchi
Fernanda Colella Antonialli
Vanessa dos Santos Grandinetti
Paulo Roberto Vicente de Paiva
Gianna Móes Albuquerque Pontes
Larissa Aline Santos
Ivo de Oliveira Aleixo Junior
Paulo de Tarso Camillo de Carvalho
Jan Magnus Bjordal
Ernesto Cesar Pinto Leal-Junior
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Trials / Issue 1/2014
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-15-69

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