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Published in: Obesity Surgery 5/2017

01-05-2017 | Original Contributions

Weight Regain 10 Years After Roux-en-Y Gastric Bypass

Authors: Daniela Vicinansa Monaco-Ferreira, Vânia Aparecida Leandro-Merhi

Published in: Obesity Surgery | Issue 5/2017

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Abstract

Objective

This study aims to investigate weight regain and the associated variables 10 years after Roux-en-Y gastric bypass.

Method

This retrospective study recruited patients submitted to Roux-en-Y gastric bypass (N = 166) for a 10-year follow-up. The following variables were investigated: body mass index (BMI), percentage of excess weight loss (%EWL), weight regain (WR), and percentage of weight regain (%WG). The chi-squared test or Fisher’s exact test compared proportions, and the Mann-Whitney test compared numerical measurements between the groups. Analysis of variance (ANOVA) compared the measurements over time. The significance level was set at 5 %.

Results

The sample had a mean age of 39.59 ± 11.69 years, and females prevailed (71.7 %). In the long-term follow-up, 41 % of the patients had weight regain. Seventy-two months after surgery, excess weight, preoperative BMI, gender, age, nutritional monitoring, and iron deficiency did not explain weight regain. Younger patients had regained significantly more weight 96 (p = 0.008) and 120 months (p = 0.004) after surgery than older patients. Patients who regained weight had ferritin <15 μg/dL 96 months after surgery (p = 0.019).

Conclusion

Patients submitted to Roux-en-Y gastric bypass presented weight regain, which increased over time. Age, iron deficiency, and time since surgery were associated with weight regain in the long-term follow-up.
Literature
1.
go back to reference Swinburn BA, Sacks G, Hall KD, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011 Aug;378(9793):804–14.CrossRefPubMed Swinburn BA, Sacks G, Hall KD, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011 Aug;378(9793):804–14.CrossRefPubMed
3.
go back to reference Associação Brasileira para o Estudo da Obesidade e da Síndrome Metabólica (ABESO): Diretrizes Brasileiras de Obesidade 2009–2010; 3a ed. p.19–22. Disponivel em: www.abeso.org.br. Acess em: 19/03/2016. Associação Brasileira para o Estudo da Obesidade e da Síndrome Metabólica (ABESO): Diretrizes Brasileiras de Obesidade 2009–2010; 3a ed. p.19–22. Disponivel em: www.​abeso.​org.​br. Acess em: 19/03/2016.
6.
go back to reference Steffen R, Potoczna N, Bieri N, et al. Successful multi-intervention treatment of severe obesity: a 7-year prospective study with 96 % follow-up. Obes Surg. 2009;19(1):3–12.CrossRefPubMed Steffen R, Potoczna N, Bieri N, et al. Successful multi-intervention treatment of severe obesity: a 7-year prospective study with 96 % follow-up. Obes Surg. 2009;19(1):3–12.CrossRefPubMed
7.
go back to reference Buchwald H, Buchwald JN, McGlennon TW. Systematic review and meta-analysis of medium-term outcomes after banded Roux-en-Y gastric bypass. Obes Surg. 2014;24(9):1536–51.CrossRefPubMed Buchwald H, Buchwald JN, McGlennon TW. Systematic review and meta-analysis of medium-term outcomes after banded Roux-en-Y gastric bypass. Obes Surg. 2014;24(9):1536–51.CrossRefPubMed
8.
go back to reference Wittgrove AC, Clark GW. Laparoscopic gastric bypass, Roux en Y—500 patients: technique and results, with 3–60 month follow-up. Obes Surg. 2000;10(3):233–9.CrossRefPubMed Wittgrove AC, Clark GW. Laparoscopic gastric bypass, Roux en Y—500 patients: technique and results, with 3–60 month follow-up. Obes Surg. 2000;10(3):233–9.CrossRefPubMed
9.
go back to reference Chakravartty S, Tassinari D, Salerno A, et al. What is the mechanism behind weight loss maintenance with gastric bypass? Curr Obes Rep. 2015;4(2):262–8.CrossRefPubMed Chakravartty S, Tassinari D, Salerno A, et al. What is the mechanism behind weight loss maintenance with gastric bypass? Curr Obes Rep. 2015;4(2):262–8.CrossRefPubMed
10.
go back to reference Umeda LM, Silva EA, Carneiro G, et al. Early improvement in glycemic control after bariatric surgery and its relationships with insulin, GLP-1 and glucagon secretion in type 2 diabetic patients. Obes Surg. 2011;21(7):896–901.CrossRefPubMed Umeda LM, Silva EA, Carneiro G, et al. Early improvement in glycemic control after bariatric surgery and its relationships with insulin, GLP-1 and glucagon secretion in type 2 diabetic patients. Obes Surg. 2011;21(7):896–901.CrossRefPubMed
11.
go back to reference Faulconbridge LF, Wadden TA, Thomas JG, et al. Changes in depression and quality of life in obese individuals with binge eating disorder: bariatric surgery versus lifestyle modification. Surg Obes Relat Dis. 2013;9(5):790–6.CrossRefPubMed Faulconbridge LF, Wadden TA, Thomas JG, et al. Changes in depression and quality of life in obese individuals with binge eating disorder: bariatric surgery versus lifestyle modification. Surg Obes Relat Dis. 2013;9(5):790–6.CrossRefPubMed
12.
go back to reference Aguera Z, Garcia-Ruiz-de-Gordejuela A, Vilarrasa N, et al. Psychological and personality predictors of weight loss and comorbid metabolic changes after bariatric surgery. Eur Eat Disord Rev. 2015;23(6):509–16.CrossRefPubMed Aguera Z, Garcia-Ruiz-de-Gordejuela A, Vilarrasa N, et al. Psychological and personality predictors of weight loss and comorbid metabolic changes after bariatric surgery. Eur Eat Disord Rev. 2015;23(6):509–16.CrossRefPubMed
13.
go back to reference Khawali C, Ferraz MB, Zanella MT, et al. Evaluation of quality of life in severely obese patients after bariatric surgery carried out in the public healthcare system. Arquivos Brasileiros de Endocrinologia & Metabologia. 2012;56(1):33–8.CrossRef Khawali C, Ferraz MB, Zanella MT, et al. Evaluation of quality of life in severely obese patients after bariatric surgery carried out in the public healthcare system. Arquivos Brasileiros de Endocrinologia & Metabologia. 2012;56(1):33–8.CrossRef
14.
go back to reference Nicoletti CF, de Oliveira BA, de Pinhel MA, et al. Influence of excess weight loss and weight regain on biochemical indicators during a 4-year follow-up after Roux-en-Y gastric bypass. Obes Surg. 2015;25(2):279–84.CrossRefPubMed Nicoletti CF, de Oliveira BA, de Pinhel MA, et al. Influence of excess weight loss and weight regain on biochemical indicators during a 4-year follow-up after Roux-en-Y gastric bypass. Obes Surg. 2015;25(2):279–84.CrossRefPubMed
15.
go back to reference Christou NV, Look D, Maclean LD. Weight gain after short and long-limb gastric bypass in patients followed for longer than 10 years. Ann Surg. 2006;244(5):734–40.CrossRefPubMedPubMedCentral Christou NV, Look D, Maclean LD. Weight gain after short and long-limb gastric bypass in patients followed for longer than 10 years. Ann Surg. 2006;244(5):734–40.CrossRefPubMedPubMedCentral
16.
go back to reference Magro DO, Geloneze B, Delfini R, et al. Long-term weight regain after gastric bypass: a 5-year prospective study. Obes Surg. 2008;18(6):648–51.CrossRefPubMed Magro DO, Geloneze B, Delfini R, et al. Long-term weight regain after gastric bypass: a 5-year prospective study. Obes Surg. 2008;18(6):648–51.CrossRefPubMed
17.
go back to reference Freire RH, Borges MC, Alvarez-Leite JI, et al. Food quality, physical activity, and nutritional follow-up as determinant of weight regain after Roux-en-Y gastric bypass. Nutrition. 2012;28(1):53–8.CrossRefPubMed Freire RH, Borges MC, Alvarez-Leite JI, et al. Food quality, physical activity, and nutritional follow-up as determinant of weight regain after Roux-en-Y gastric bypass. Nutrition. 2012;28(1):53–8.CrossRefPubMed
18.
go back to reference Barhouch AS, Padoin AV, Casagrande DS, et al. Predictors of excess weight loss in obese patients after gastric bypass: a 60-month follow-up. Obes Surg. 2016;26(6):1178–85.CrossRefPubMed Barhouch AS, Padoin AV, Casagrande DS, et al. Predictors of excess weight loss in obese patients after gastric bypass: a 60-month follow-up. Obes Surg. 2016;26(6):1178–85.CrossRefPubMed
19.
go back to reference Odom J, Zalesin KC, Washington TL, et al. Behavioral predictors of weight regain after bariatric surgery. Obes Surg. 2010;20(3):349–56.CrossRefPubMed Odom J, Zalesin KC, Washington TL, et al. Behavioral predictors of weight regain after bariatric surgery. Obes Surg. 2010;20(3):349–56.CrossRefPubMed
20.
go back to reference Abu Dayyeh BK, Lautz DB, Thompson CC. Gastrojejunal stoma diameter predicts weight regain after Roux-en-Y gastric bypass. Clin Gastroenterol Hepatol. 2011;9(3):228–33.CrossRefPubMed Abu Dayyeh BK, Lautz DB, Thompson CC. Gastrojejunal stoma diameter predicts weight regain after Roux-en-Y gastric bypass. Clin Gastroenterol Hepatol. 2011;9(3):228–33.CrossRefPubMed
21.
go back to reference Cooper TC, Simmons EB, Webb K, et al. Trends in weight regain following Roux-en-Y gastric bypass (RYGB) bariatric surgery. Obes Surg. 2015;25(8):1474–81.CrossRefPubMed Cooper TC, Simmons EB, Webb K, et al. Trends in weight regain following Roux-en-Y gastric bypass (RYGB) bariatric surgery. Obes Surg. 2015;25(8):1474–81.CrossRefPubMed
22.
go back to reference Still CD, Wood GC, Chu X, et al. Clinical factors associated with weight loss outcomes after Roux-en-Y gastric bypass surgery. Obesity. 2014;22(3):888–94.CrossRefPubMedPubMedCentral Still CD, Wood GC, Chu X, et al. Clinical factors associated with weight loss outcomes after Roux-en-Y gastric bypass surgery. Obesity. 2014;22(3):888–94.CrossRefPubMedPubMedCentral
23.
go back to reference Higa K, Ho T, Tercero F, et al. Laparoscopic Roux-en-Y gastric bypass: 10-year follow-up. Surg Obes Relat Dis. 2011;7(4):516–25.CrossRefPubMed Higa K, Ho T, Tercero F, et al. Laparoscopic Roux-en-Y gastric bypass: 10-year follow-up. Surg Obes Relat Dis. 2011;7(4):516–25.CrossRefPubMed
24.
go back to reference Puzziferi N, Roshek TB, Mayo HG, et al. Long-term follow-up after bariatric surgery. A systematic review. J Am Med Assoc. 2014;312(9):934–42.CrossRef Puzziferi N, Roshek TB, Mayo HG, et al. Long-term follow-up after bariatric surgery. A systematic review. J Am Med Assoc. 2014;312(9):934–42.CrossRef
25.
go back to reference Deitel M, Greenstein RJ. Recommendations for reporting weight loss. Obes Surg. 2003;13(2):159–60.CrossRefPubMed Deitel M, Greenstein RJ. Recommendations for reporting weight loss. Obes Surg. 2003;13(2):159–60.CrossRefPubMed
26.
go back to reference Novais PF, Rasera Junior I, Leite CV, et al. Body weight evolution and classification of body weight in relation to the results of bariatric surgery: Roux-en-Y gastric bypass. Arquivos Brasileiros de Endocrinologia e Metabologia. 2010;54(3):303–10.CrossRefPubMed Novais PF, Rasera Junior I, Leite CV, et al. Body weight evolution and classification of body weight in relation to the results of bariatric surgery: Roux-en-Y gastric bypass. Arquivos Brasileiros de Endocrinologia e Metabologia. 2010;54(3):303–10.CrossRefPubMed
29.
go back to reference SAS system for Windows (Statistical Analysis System), versão 9.4. SAS Institute Inc, 2002–2012, Cary, NC, USA. SAS system for Windows (Statistical Analysis System), versão 9.4. SAS Institute Inc, 2002–2012, Cary, NC, USA.
30.
go back to reference Conover WJ. Practical nonparametric statistics. 3ª ed. Nova Iorque: Wiley; 1999. Conover WJ. Practical nonparametric statistics. 3ª ed. Nova Iorque: Wiley; 1999.
31.
go back to reference Conover WJ, Iman RL. Rank transformations as a bridge between parametric and nonparametric statistics. Am Stat. 1981;35(3):124–9. Conover WJ, Iman RL. Rank transformations as a bridge between parametric and nonparametric statistics. Am Stat. 1981;35(3):124–9.
32.
go back to reference Tabachnick BG, Fidell LS. Using multivariate statistics, 4th ed. Boston: Allyn and Bacon; 2001. p. 966. Tabachnick BG, Fidell LS. Using multivariate statistics, 4th ed. Boston: Allyn and Bacon; 2001. p. 966.
34.
go back to reference Berti LV, Campos J, Ramos A, et al. Position of the SBCBM—nomenclature and definition of outcomes of bariatric and metabolic surgery. Arquivos Brasileiros de Cirurgia Digestiva (ABCD). 2015;28(1):2.CrossRef Berti LV, Campos J, Ramos A, et al. Position of the SBCBM—nomenclature and definition of outcomes of bariatric and metabolic surgery. Arquivos Brasileiros de Cirurgia Digestiva (ABCD). 2015;28(1):2.CrossRef
35.
go back to reference Sjöström L. Review of the key results from the Swedish Obese Subjects (SOS) trial—a prospective controlled intervention study of bariatric surgery. J Intern Med. 2013;273(3):219–34.CrossRefPubMed Sjöström L. Review of the key results from the Swedish Obese Subjects (SOS) trial—a prospective controlled intervention study of bariatric surgery. J Intern Med. 2013;273(3):219–34.CrossRefPubMed
36.
go back to reference Sjöström G, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.CrossRefPubMed Sjöström G, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.CrossRefPubMed
37.
go back to reference Cambi MP, Marchesini SD, Baretta GA. Post-bariatric surgery weight regain: evaluation of nutritional profile of candidate patients for endoscopic argon plasma coagulation. Arquivos Brasileiros de Ciruriga Digestiva (ABCD). 2015;28(1):40–3.CrossRef Cambi MP, Marchesini SD, Baretta GA. Post-bariatric surgery weight regain: evaluation of nutritional profile of candidate patients for endoscopic argon plasma coagulation. Arquivos Brasileiros de Ciruriga Digestiva (ABCD). 2015;28(1):40–3.CrossRef
Metadata
Title
Weight Regain 10 Years After Roux-en-Y Gastric Bypass
Authors
Daniela Vicinansa Monaco-Ferreira
Vânia Aparecida Leandro-Merhi
Publication date
01-05-2017
Publisher
Springer US
Published in
Obesity Surgery / Issue 5/2017
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-016-2426-3

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