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Archives of Dermatological Research
Published in: Archives of Dermatological Research 5/2023

Open Access 26-12-2022 | Wart | ORIGINAL PAPER

Intralesional Candida albicans antigen versus intralesional zinc sulfate in treatment of cutaneous warts

Authors: Eman M. Kamal Youssef, Maha A. A. Eissa, Radwa M. Bakr

Published in: Archives of Dermatological Research | Issue 5/2023

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Abstract

Immunotherapy represents a promising therapeutic option for treatment of warts. Different concentrations of Candida antigen (1/100 and 1/1000) and zinc sulfate 2% were not previously compared regarding their efficacy in treatment of cutaneous warts. The present study compared the safety and efficacy of intralesional candida antigen versus intralesional 2% zinc sulfate for treatment of cutaneous warts. This prospective controlled clinical trial included one hundred and five patients presented with common, plantar, and plane warts. Patients were divided randomly into three groups, each group included 35 patients. Group 1 were treated with intralesional candida antigen (Ag) 1/100, Group 2 were treated with intralesional candida Ag 1/1000, and Group 3 were treated with intralesional zinc sulfate 2%. This study found that target warts of group 1 displayed higher rate of complete clearance compared to group 2 and group 3 (94.3%, 77.1, 74.2%), respectively. The present study concluded that intralesional immunotherapy with Candida antigen was more effective than Intralesional 2% zinc sulfate in treatment of cutaneous warts and less painful. Clinical trial registration number is (Clinical Trials.gov Identifier: NCT03158168).
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Metadata
Title
Intralesional Candida albicans antigen versus intralesional zinc sulfate in treatment of cutaneous warts
Authors
Eman M. Kamal Youssef
Maha A. A. Eissa
Radwa M. Bakr
Publication date
26-12-2022
Publisher
Springer Berlin Heidelberg
Keyword
Wart
Published in
Archives of Dermatological Research / Issue 5/2023
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-022-02499-w

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