Top

BMC Medical Genetics

Published in:

Open Access 01-12-2019 | Vulgar Psoriasis | Research article

Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis

Authors: Juan Li, Li Sun, Jinghui Sun, Min Yan

Published in: BMC Medical Genetics | Issue 1/2019

Abstract

Background

The study aims at scientifically investigating the genetic effect of four polymorphisms (rs7975232, rs1544410, rs2228570, and rs731236) within the human Vitamin D Receptor (VDR) gene on the odds of psoriasis through an updated meta-analysis.

Methods

We searched eight databases and screened the studies for pooling. Finally, a total of eighteen eligible case-control studies were included. BH (Benjamini & Hochberg) adjusted P-values of association (P_association) and odd ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated under the allele, homozygote, heterozygote, dominant, recessive, and carrier models.

Results

Compared with the negative controls, no statistically significant difference in the odds of psoriasis was detected for the cases under any genetic models (BH adjusted P_association > 0.05). We also performed subgroup meta-analyses by the source of controls, ethnicity, country, Hardy-Weinberg equilibrium, and genotyping method. Similar results were observed in most subgroup meta-analyses (BH adjusted P_association > 0.05). Besides, data of Begg’s and Egger’s tests excluded the significant publication bias; while the sensitivity analysis data further indicated the statistical reliability of our pooling results.

Conclusion

The currently available data fails to support a robust association between VDR rs7975232, rs1544410, rs2228570 and rs731236 polymorphisms and psoriasis susceptibility, which still required the support of more case-control studies.

Available only for authorised users

Zenata O, Vrzal R. Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications. Oncotarget. 2017;8(21):35390–402.PubMedPubMedCentralCrossRef

Saccone D, Asani F, Bornman L. Regulation of the vitamin D receptor gene by environment, genetics and epigenetics. Gene. 2015;561(2):171–80.PubMedCrossRef

Lee YH. Vitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility: an updated meta-analysis. Clin Exp Dermatol. 2019;44(5):498–505.PubMedCrossRef

Stefanic M, Rucevic I, Barisic-Drusko V. Meta-analysis of vitamin D receptor polymorphisms and psoriasis risk. Int J Dermatol. 2013;52(6):705–10.PubMedCrossRef

Liu JL, Zhang SQ, Zeng HM. ApaI, BsmI, FokI and TaqI polymorphisms in the vitamin D receptor (VDR) gene and the risk of psoriasis: a meta-analysis. J Eur Acad Dermatol Venereol. 2013;27(6):739–46.PubMedCrossRef

Kostner K, Denzer N, Muller CS, Klein R, Tilgen W, Reichrath J. The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. Anticancer Res. 2009;29(9):3511–36.PubMed

Labuda M, Fujiwara TM, Ross MV, Morgan K, Garcia-Heras J, Ledbetter DH, Hughes MR, Glorieux FH. Two hereditary defects related to vitamin D metabolism map to the same region of human chromosome 12q13-14. J Bone Miner Res. 1992;7(12):1447–53.PubMedCrossRef

Schadler ED, Ortel B, Mehlis SL. Biologics for the primary care physician: review and treatment of psoriasis. Dis Mon. 2019;65(3):51–90.PubMedCrossRef

Yadav K, Singh D, Singh MR. Protein biomarker for psoriasis: A systematic review on their role in the pathomechanism, diagnosis, potential targets and treatment of psoriasis. Int J Biol Macromol. 2018;118(Pt B):1796–810.PubMedCrossRef

10.

Grozdev I, Korman N, Tsankov N. Psoriasis as a systemic disease. Clin Dermatol. 2014;32(3):343–50.PubMedCrossRef

11.

Chandra A, Ray A, Senapati S, Chatterjee R. Genetic and epigenetic basis of psoriasis pathogenesis. Mol Immunol. 2015;64(2):313–23.PubMedCrossRef

12.

O'Rielly DD, Rahman P. Genetic, epigenetic and Pharmacogenetic aspects of psoriasis and psoriatic arthritis. Rheum Dis Clin N Am. 2015;41(4):623–42.CrossRef

13.

Lee DY, Park BS, Choi KH, Jeon JH, Cho KH, Song KY, Kim IG, Youn JI. Vitamin D receptor genotypes are not associated with clinical response to calcipotriol in Korean psoriasis patients. Arch Dermatol Res. 2002;294(1–2):1–5.PubMedCrossRef

14.

Park BS, Park JS, Lee DY, Youn JI, Kim IG. Vitamin D receptor polymorphism is associated with psoriasis. J Invest Dermatol. 1999;112(1):113–6.PubMedCrossRef

15.

Liu JL, Zeng HM, Lin MG, Ju M, Wu ZM, Li MJ, Li MJ, Liu YY, Yin M. Association of vitamin D receptor polymorphisms with susceptibility to psoriasis vulgaris and clinical response to calcipotriol in patients with psoriasis vulgaris. Chin J Dermatol. 2017;50(12):889–93.

16.

Dayangac-Erden D, Karaduman A, Erdem-Yurter H. Polymorphisms of vitamin D receptor gene in Turkish familial psoriasis patients. Arch Dermatol Res. 2007;299(10):487–91.PubMedCrossRef

17.

Kaya TI, Erdal ME, Tursen U, Camdeviren H, Gunduz O, Soylemez F, Ikizoglu G. Association between vitamin D receptor gene polymorphism and psoriasis among the Turkish population. Arch Dermatol Res. 2002;294(6):286–9.PubMedCrossRef

18.

Okita H, Ohtsuka T, Yamakage A, Yamazaki S. Polymorphism of the vitamin D(3) receptor in patients with psoriasis. Arch Dermatol Res. 2002;294(4):159–62.PubMedCrossRef

19.

Richetta AG, Silvestri V, Giancristoforo S, Rizzolo P, D'Epiro S, Graziano V, Mattozzi C, Navazio AS, Campoli M, D'Amico C, et al. A-1012G promoter polymorphism of vitamin D receptor gene is associated with psoriasis risk and lower allele-specific expression. DNA Cell Biol. 2014;33(2):102–9.PubMedCrossRef

20.

Rucevic I, Stefanic M, Tokic S, Vuksic M, Glavas-Obrovac L, Barisic-Drusko V. Lack of association of vitamin D receptor gene 3′-haplotypes with psoriasis in Croatian patients. J Dermatol. 2012;39(1):58–62.PubMedCrossRef

21.

Zuel-Fakkar NM, Kamel MM, Asaad MK, Mahran MZ, Shehab AA. A study of ApaI and TaqI genotypes of the vitamin D receptor in Egyptian patients with psoriasis. Clin Exp Dermatol. 2011;36(4):355–9.PubMedCrossRef

22.

Acikbas I, Sanli B, Tepeli E, Ergin S, Aktan S, Bagci H. Vitamin D receptor gene polymorphisms and haplotypes (Apa I, Bsm I, Fok I, Taq I) in Turkish psoriasis patients. Med Sci Monit. 2012;18(11):Cr661–6.PubMedPubMedCentralCrossRef

23.

Kontula K, Valimaki S, Kainulainen K, Viitanen AM, Keski-Oja J. Vitamin D receptor polymorphism and treatment of psoriasis with calcipotriol. Br J Dermatol. 1997;136(6):977–8.PubMedCrossRef

24.

Saeki H, Asano N, Tsunemi Y, Takekoshi T, Kishimoto M, Mitsui H, Tada Y, Torii H, Komine M, Asahina A, et al. Polymorphisms of vitamin D receptor gene in Japanese patients with psoriasis vulgaris. J Dermatol Sci. 2002;30(2):167–71.PubMedCrossRef

25.

Zhu HQ, Xie KC, Chen LD, Zhu GD. The association between vitamin D receptor polymorphism and psoriasis. Chin J Dermatol. 2002;35(5):386–8.

26.

Mee JB, Cork MJ. Vitamin D receptor polymorphism and calcipotriol response in patients with psoriasis. J Invest Dermatol. 1998;110(3):301–2.PubMedCrossRef

27.

Halsall JA, Osborne JE, Pringle JH, Hutchinson PE. Vitamin D receptor gene polymorphisms, particularly the novel A-1012G promoter polymorphism, are associated with vitamin D3 responsiveness and non-familial susceptibility in psoriasis. Pharmacogenet Genomics. 2005;15(5):349–55.PubMedCrossRef

28.

Ruggiero M, Gulisano M, Peruzzi B, Giomi B, Caproni M, Fabbri P, Pacini S. Vitamin D receptor gene polymorphism is not associated with psoriasis in the Italian Caucasian population. J Dermatol Sci. 2004;35(1):68–70.PubMedCrossRef

29.

Zhou X, Xu LD, Li YZ. The association of polymorphisms of the vitamin D receptor gene with psoriasis in the Han population of northeastern China. J Dermatol Sci. 2014;73(1):63–6.PubMedCrossRef

30.

Zhao Y, Chen X, Li J, He Y, Su J, Chen M, Zhang W, Chen W, Zhu W. VDR gene polymorphisms are associated with the clinical response to calcipotriol in psoriatic patients. J Dermatol Sci. 2015;79(3):305–7.PubMedCrossRef

31.

Lee YH, Choi SJ, Ji JD, Song GG. Vitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility: a meta-analysis. Mol Biol Rep. 2012;39(6):6471–8.PubMedCrossRef

Title: Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis
Authors: Juan Li
Li Sun
Jinghui Sun
Min Yan
Publication date: 01-12-2019
Publisher: BioMed Central
Keyword: Vulgar Psoriasis
Published in: BMC Medical Genetics / Issue 1/2019
Electronic ISSN: 1471-2350
DOI: https://doi.org/10.1186/s12881-019-0896-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2019

A case report and mechanism analysis of a normal phenotype mosaic 47, XXY complicated by paternal iUPD (9) who had a normal PGD result

MMP-8 C-799 T, Lys460Thr, and Lys87Glu variants are not related to risk of cancer

Autoimmune Polyglandular Syndrome Type 1: a case report

SIRT1 (rs3740051) role in pituitary adenoma development

The prevalence of CGG repeat expansion mutation in FMR1 gene in the northern Chinese women of reproductive age

Genetic basis of rotator cuff injury: a systematic review