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01-05-2019 | Vulgar Psoriasis | Original Paper

Association of GA genotype of SNP rs4680 in COMT gene with psoriasis

Authors: Vladimir Sobolev, Luiza Sakaniya, Artemii Tretiakov, Zarema Kokaeva, Elena Naumova, Olga Rudko, Anna Soboleva, Ivan Danilin, Irina Korsunskaya, Eugene Klimov

Published in: Archives of Dermatological Research | Issue 4/2019

Abstract

Psoriasis is a multigene and multifactorial skin disease with heterogeneous genetic inheritance. Mental disorders participate in the development of psoriasis as predisposing factors; a correlation of dermatological diseases with pathological anxiety and stress was shown. Meanwhile, there are no studies describing molecular mechanisms of the linkages between psycho-emotional disorders and skin diseases. The aim of this study is to find the associations between SNP in genes COMT (rs4680), DBH (rs141116007), CCKAR (rs1800857) and CCKBR (rs1805002), and psoriasis. Patients were selected according to the 10th revision of International Classification of Diseases (L-40). The sample size was 88 patients. The size of the control sample (population control) was 365 people. Genotyping was performed using PCR-RFLP and real-time PCR. Statistical analysis was performed using WinPepi software. Identification of complex genotypes was performed by the Monte Carlo method using APSampler 3.6.1 algorithm. Among the studied genes, only GA genotype of COMT gene is significantly associated with psoriasis [χ² = 19.163 (p = 1.3E−5), F (p) = 1.2E−5, OR 3.47 (CI 99% = 1.61–7.91)]. At the moment, the functional significance of this phenomenon is difficult to explain.

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Title: Association of GA genotype of SNP rs4680 in COMT gene with psoriasis
Authors: Vladimir Sobolev
Luiza Sakaniya
Artemii Tretiakov
Zarema Kokaeva
Elena Naumova
Olga Rudko
Anna Soboleva
Ivan Danilin
Irina Korsunskaya
Eugene Klimov
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Keyword: Vulgar Psoriasis
Published in: Archives of Dermatological Research / Issue 4/2019
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-019-01904-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association of GA genotype of SNP rs4680 in COMT gene with psoriasis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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