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Intensive Care Medicine
Published in: Intensive Care Medicine 3/2013

01-03-2013 | Correspondence

Voriconazole-induced bradycardia without QT interval prolongation: a possible non-concentration-dependent adverse effect

Authors: Sébastien Perbet, Raiko Blondonnet, Renaud Guérin, Sophie Cayot-Constantin, Jean-Michel Constantin

Published in: Intensive Care Medicine | Issue 3/2013

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Excerpt

Dear Editor, …
Literature
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Burghi G, Lemiale V, Seguin A, Lambert J, Lacroix C, Canet E, Moreau AS, Ribaud P, Schnell D, Mariotte E, Schlemmer B, Azoulay E (2011) Outcomes of mechanically ventilated hematology patients with invasive pulmonary aspergillosis. Intensive Care Med 37:1605–1612PubMedCrossRef
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Pascual A, Calandra T, Bolay S, Buclin T, Bille J, Marchetti O (2008) Voriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomes. Clin Infect Dis 46:201–211PubMedCrossRef
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Zimmermann M, Duruz H, Guinand O, Broccard O, Levy P, Lacatis D, Bloch A (1992) Torsades de Pointes after treatment with terfenadine and ketoconazole. Eur Heart J 13:1002–1003PubMed
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Alkan Y, Haefeli WE, Burhenne J, Stein J, Yaniv I, Shalit I (2004) Voriconazole-induced QT interval prolongation and ventricular tachycardia: a non-concentration-dependent adverse effect. Clin Infect Dis 39:e49–e52PubMedCrossRef
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Dumaine R, Roy ML, Brown AM (1998) Blockade of HERG and Kv1.5 by ketoconazole. J Pharmacol Exp Ther 286:727–735PubMed
Metadata
Title
Voriconazole-induced bradycardia without QT interval prolongation: a possible non-concentration-dependent adverse effect
Authors
Sébastien Perbet
Raiko Blondonnet
Renaud Guérin
Sophie Cayot-Constantin
Jean-Michel Constantin
Publication date
01-03-2013
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 3/2013
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-012-2776-9

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