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Osteoporosis International

Published in:

01-01-2007 | Original Article

Volumetric bone mineral density and bone size in sleep-deprived individuals

Authors: B. L. Specker, T. Binkley, M. Vukovich, T. Beare

Published in: Osteoporosis International | Issue 1/2007

Abstract

Introduction

Chronic sleep deprivation, which is associated with several age-related pathologies and altered endocrine function, may adversely affect bone. Our a priori hypothesis was that bone mineral density was lower in sleep-deprived (<6.5 h/night) vs. sleep-adequate (>6.5-10 h/night) individuals.

Methods

Cross-sectional analysis of sleep and bone data on 1,146 individuals (652 women) was performed. Measurements were obtained at the distal radius by pQCT, and the spine and hip by DXA. Bone differences between sleep-deprived and sleep-adequate groups were compared after stratifying by sex and controlling for covariates.

Results

Overall, 19% of the population was sleep deprived. Sleep-deprived women had lower cortical volumetric BMD (1,208±4 vs. 1,219±2 mg/cm³, P=0.03) than sleep-adequate women. Sleep-deprived men had lower pSSI, an estimate of torsional bending strength, than sleep-adequate men (358±10 vs. 382±5 mm³, P=0.04), due to a slightly smaller periosteal circumference (43.9±0.4 vs. 44.8±0.2 mm, P=0.07) and cortical area (103±2 vs. 106±1±mm², P=0.06).

Conclusion

Sleep deprivation is associated with some, but not all, bone outcomes. These findings may have important public health significance given the increasing prevalence of sleep deprivation.

Bonnet MH, Arand DL (1995) We are chronically sleep deprived. Sleep 18:908–911PubMed

Spiegel K, Leproult R, Van Cauter E (1999) Impact of sleep debt on metabolic and endocrine functions. Lancet 354:1435–1439PubMedCrossRef

Blumsohn A, Herrington K, Hannon RA, Shao P, Eyre DR, Eastell R (1994) The effect of calcium supplementation on the circadian rhythm of bone resorption. J Clin Endocrinol Metab 79:730–735PubMedCrossRef

Chapotot F, Gronfier C, Spiegel K, Luthringer R, Brandenberger G (1996) Relationships between intact parathyroid hormone 24-hour profiles, sleep-wake cycle, and sleep electroencephalographic activity in men. J Clin Endocrinol Metab 81:3759–3765PubMedCrossRef

Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC (1998) Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 102:274–282PubMedCrossRef

Van Cauter E, Plat L, Leproult R, Copinschi G (1998) Alteractions of circadian rhythmicity and sleep in aging: endocrine consequences. Horm Res 49:147–152PubMedCrossRef

Wong SYS, Lau EMC, Lynn H, Leung PC, Wood J, Cummings SR, Orwoll ES (2005) Depression and bone mineral density: is there a relationship in elderly Asian men? Results from Mr. Os (Hong Kong). Osteoporos Int 16:610–615PubMedCrossRef

Mussolino ME (2005) Depression and hip fracture risk-The NHANES I follow-up study. Public Health Rep 120:71–75PubMed

Scane AC, Francis RM, Sutcliffe AM, Francis MJD, Rawlings DJ, Chapple CL (1999) Case-control study of the pathogenesis and sequelae of symptomatic vertebral fractures in men. Osteoporos Int 9:91–97PubMedCrossRef

10.

Sogaard AJ, Joakimsen RM, Tverdal A, Fonnebo V, Magnus JH, Berntsen GKR (2005) Long-term mental distress, bone mineral density and non-vertebral fractures. The Tromso Study. Osteoporos Int 16:887–897PubMedCrossRef

11.

Uusi-Rasi K, Sievanen H, Pasanen M, Oja P, Vuori I (2002) Associations of calcium intake and physical activity with bone density and size in premenopausal and postmenopausal women: a peripheral quantitative computed tomography study. J Bone Miner Res 17:544–552PubMedCrossRef

12.

Specker B, Binkley T, Fahrenwald N (2004) Rural vs. non-rural differences in BMC, volumetric BMD, and bone size: a population-based cross-sectional study. Bone 35:1389–1398PubMedCrossRef

13.

Paffenbarger RS, Wing AL, Hyde RT (1978) Physical activity as an index of heart attack risk in college alumni. Am J Epidemiol 108:161–175PubMed

14.

Hasegawa Y, Schneider P, Reiners C (2001) Age, sex, and grip strength determine architectural bone parameters assessed by peripheral quantitative computed tomography (pQCT) at the human radius. J Biomech 34:497–503PubMedCrossRef

15.

Mahowald MW (2000) What is causing excessive daytime sleepiness? Postgrad Med Online 107

16.

Wosje KS, Binkley TL, Fahrenwald NL, Specker BL (2000) High bone mass in a female Hutterite population. J Bone Miner Res 15:1429–1436PubMedCrossRef

17.

Orwoll ES (2003) Toward an expanded understanding of the role of the periosteum in skeletal health. J Bone Miner Res 18:949–954PubMedCrossRef

18.

Frost H (1989) Mechanical usage, bone mass, bone fragility: a brief overview. In: Kleerekoper M, Krane S (eds) Clinical disorders of bone and mineral metabolism. Liebert, New York, pp 15–40

19.

Seeman E, Duan Y, Fong C, Edmonds J (2001) Fracture site-specific deficits in bone size and volumetric density in men with spine or hip fractures. J Bone Miner Res 16:120–127PubMedCrossRef

20.

Gilsanz V, Loro ML, Roe TF, Sayre J, Gilsanz R, Schulz EE (1995) Vertebral size in elderly women with osteoporosis. J Clin Invest 95:2332–2337PubMedCrossRef

21.

Mussolinio ME, Jonas BS, Looker AC (2004) Depression and bone mineral density in young adults: results from NHANES III. Psychosom Med 66:533–537CrossRef

22.

Schweiger U, Weber B, Deuschle M, Heuser I (2000) Lumbar bone mineral density in patients with major depression: evidence of increased bone loss at follow-up. Am J Psychiatry 157:118–120PubMed

23.

Barrett-Connor E, VonMuehlen DG, Kritz-Silverstein D (1999) Bioavailable testosterone and depressed mood in older men: The Rancho Bernardo study. J Clin Endocrinol Metab 84:573–577PubMedCrossRef

24.

Luboshitzky R, Zabari Z, Shen-Orr Z, Herer P, Lavie P (2001) Disruption of the nocturnal testosterone rhythm by sleep fragmentation in normal men. J Clin Endocrinol Metab 86:1134–1139PubMedCrossRef

25.

Turner RT, Hannon KS, Demers LM, Buchanan J, Bell NH (1989) Differential effects of gonadal function on bone histomorphometry in male and females rats. J Bone Miner Res 4:557–563PubMed

26.

Seeman E (2002) Pathogenesis of bone fragility in women and men. Lancet 359:1841–1850PubMedCrossRef

27.

Empson JA, Purdie DW (1999) Effects of sex steroids on sleep. Ann Med 31:141–145PubMedCrossRef

28.

Jarvinen TL, Kannus P, Sievanen H (2003) Estrogen and bone-a reproductive and locomotive perspective. J Bone Miner Res 18:1921–1931PubMedCrossRef

29.

Logue FC, Fraser WD, O’Reilly SJ, Christie J, Cameron DA, Wallace DC, Beastall GH (1992) Sleep shift dissociates the nocturnal peaks of parathyroid hormone (1-84), nephrogenous cyclic adenosine monophosphate, and prolactin in normal men. J Clin Endocrinol Metab 75:25–29PubMedCrossRef

30.

Bilezikian JP, Silverberg SJ, Shane E, Parisien M, Dempster DW (1991) Characterization and evaluation of asymptomatic primary hyperparathyroidism. J Bone Miner Res 6:S85–S89PubMedCrossRef

31.

Zhang XZ, Kalu DN, Erbas B, Hopper JL, Seeman E (1999) The effect of gonadectomy on bone size, mass and volumetric density in growing rats may be gender-site-and growth hormone-dependent. J Bone Miner Res 14:802–809PubMedCrossRef

32.

Nieminen P, Loeppoenen T, Tolonen U, Lanning P, Knip M, Loeppoenen H (2002) Growth and biochemical markers of growth in children with snoring and obstructive sleep apnea. Pediatr 109:e55CrossRef

33.

Duan Y, Turner CH, Kim B, Seeman E (2001) Sexual dimorphism in vertebral fragility is more the result of gender differences in age-related bone gain than bone loss. J Bone Miner Res 16:2267–2275PubMedCrossRef

34.

Melton III LJ, Crowson CS, O’Fallon WM (1999) Fracture incidence in Olmsted County, Minnesota: Comparison of urban with rural rates and changes in urban rates over time. Osteoporos Int 9:29–37PubMedCrossRef

Title: Volumetric bone mineral density and bone size in sleep-deprived individuals
Authors: B. L. Specker
T. Binkley
M. Vukovich
T. Beare
Publication date: 01-01-2007
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 1/2007
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-006-0207-x

At a glance: The STEP trials

Springer Medicine

Volumetric bone mineral density and bone size in sleep-deprived individuals

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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