Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
International Urogynecology Journal
Published in: International Urogynecology Journal 2/2008

01-02-2008 | Original Article

Volume changes and histological response to injected dextranomer/hyaluronic acid copolymer (Zuidex™) and collagen (Contigen®) in rats

Authors: Ehab A. Elzayat, Gilles Karsenty, Tarek A. Bismar, Jacques Corcos

Published in: International Urogynecology Journal | Issue 2/2008

Login to get access

Abstract

The objective of this study was to investigate the stability in terms of volume changes and local tissue reactions of dextranomer (Dx)/hyaluronic acid (HA) and collagen implants. A total of 57 rats were included in this study: the control group (nine rats), collagen-injected group (24 rats), and Dx/HA copolymer-injected group (24 rats). Under anesthesia, 0.35 ml of bulking agents was injected subcutaneously in the abdominal area. At 1, 6, and12 months, eight animals of the two implant groups and three animals of the control group were killed. The area of the injected material and surrounding tissue were carefully resected for histopathological examination. Mean volume changes in the Dx/HA copolymer group were 0.56 ± 0.12, 0.43 ± 0.08, and 0.28 ± 0.02 ml at 1, 6, and 12 months, respectively. Mean volume changes in the collagen group were 0.25 ± 0.03, 0.21 ± 0.08, and 0.21 ± 0.01 at 1, 6, and 12 months, respectively. The degree of tissue reaction and fibrosis are more pronounced in the Dx/HA copolymer group at each measurement period after injection.
Literature
1.
Murless B (1938) The injection treatment of stress urinary incontinence. J Obstet Gynaecol Br Emp 45:67–73
2.
Lopez AE, Padron OF, Patsias G, Politano VA (1993) Transurethral polytetrafluoroethylene injection in female patients with urinary continence. J Urol 150:856–858PubMed
3.
Politano VA, Small MP, Harper JM, Lynne CM (1974) Periurethral teflon injection for urinary incontinence. J Urol 111:180–183PubMed
4.
Malizia AA Jr, Reiman HM, Myers RP et al (1984) Migration and granulomatous reaction after periurethral injection of polytef (Teflon). JAMA 251:3277–3281PubMedCrossRef
5.
Henly DR, Barrett DM, Weiland TL, O’Connor MK, Malizia AA, Wein AJ (1995) Particulate silicone for use in periurethral injections: local tissue effects and search for migration. J Urol 153:2039–2043PubMedCrossRef
6.
Dewan PA, Owen AJ, Byard RW (1995) Long-term histological response to subcutaneously injected Polytef and Bioplastique in a rat model. Br J Urol 76:161–164PubMed
7.
Shortliffe LM, Freiha FS, Kessler R, Stamey TA, Constantinou CE (1989) Treatment of urinary incontinence by the periurethral implantation of glutaraldehyde cross-linked collagen. J Urol 141:538–541PubMed
8.
Stenberg AM, Sundin A, Larsson BS, Lackgren G, Stenberg A (1997) Lack of distant migration after injection of a 125 iodine labeled dextranomer based implant into the rabbit bladder. J Urol 158:1937–1941PubMedCrossRef
9.
Stenberg AM, Larsson G, Johnson P (2003) Urethral injection for stress urinary incontinence: long-term results with dextranomer/hyaluronic acid copolymer. Int Urogynecol J Pelvic Floor Dysfunct 14:335–338PubMedCrossRef
10.
Appell RA (1994) Collagen injection therapy for urinary incontinence. Urol Clin North Am 21:177–182PubMed
11.
Appell RA (1990) New developments: injectables for urethral incompetence in women. Int Urogynecol J 1:117–119CrossRef
12.
Nataluk EA, Assimos DG, Kroovand RL (1995) Collagen injections for treatment of urinary incontinence secondary to intrinsic sphincter deficiency. J Endourol 9:403–406PubMedCrossRef
13.
Monga AK, Stanton SL (1997) Urodynamics: prediction, outcome and analysis of mechanism for cure of stress incontinence by periurethral collagen. Br J Obstet Gynaecol 104:158–162PubMed
14.
Frey P, Mangold S (1995) Physical and histological behavior of a new injectable collagen (GAX 65) implanted into the submucosal space of the mini-pig bladder. J Urol 154:812–815PubMedCrossRef
15.
Su TH, Hsu CY, Chen JC (1999) Injection therapy for stress incontinence in women. Int Urogynecol J Pelvic Floor Dysfunct 10:200–206PubMedCrossRef
16.
Corcos J, Fournier C (1999) Periurethral collagen injection for the treatment of female stress urinary incontinence: 4-year follow-up results. Urology 54:815–818PubMedCrossRef
17.
McGuire EJ, English SF (1997) Periurethral collagen injection for male and female sphincteric incontinence: indications, techniques, and result. World J Urol 15:306–309PubMedCrossRef
18.
Maki DD, Banner MP, Ramchandani P, Stolpen A, Rovner ES, Wein AJ (2000) Injected periurethral collagen for postprostatectomy urinary incontinence: MR and CT appearance. Abdom Imaging 25:658–662PubMedCrossRef
19.
Carr LK, Herschorn S, Leonhardt C (1996) Magnetic resonance imaging after intraurethral collagen injected for stress urinary incontinence. J Urol 155:1253–1255PubMedCrossRef
20.
Defreitas GA, Wilson TS, Zimmern PE, Forte TB (2003) Three-dimensional ultrasonography: an objective outcome tool to assess collagen distribution in women with stress urinary incontinence. Urology 62:232–236PubMedCrossRef
21.
Stenberg A, Larsson E, Lindholm A, Ronneus B, Stenberg A, Lackgren G (1999) Injectable dextranomer-based implant: histopathology, volume changes and DNA-analysis. Scand J Urol Nephrol 33:355–361PubMedCrossRef
22.
Stenberg A, Larsson E, Lackgren G (2003) Endoscopic treatment with dextranomer-hyaluronic acid for vesicoureteral reflux: histological findings. J Urol 169:1109–1113PubMedCrossRef
Metadata
Title
Volume changes and histological response to injected dextranomer/hyaluronic acid copolymer (Zuidex™) and collagen (Contigen®) in rats
Authors
Ehab A. Elzayat
Gilles Karsenty
Tarek A. Bismar
Jacques Corcos
Publication date
01-02-2008
Publisher
Springer-Verlag
Published in
International Urogynecology Journal / Issue 2/2008
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-007-0414-9

Other articles of this Issue 2/2008

International Urogynecology Journal 2/2008 Go to the issue

Erratum

Partial colpocleisis for the treatment of sacrocolpopexy mesh erosions

Original Article

Urodynamic changes after tension-free sling procedures: Mycromesh-Plus® vs TVT sling®

In Memoriam

A tribute to a great academic pelvic surgeon: Professor Ahmed Shafik (1933–2007)

Original Article

The effect of spinal anaesthesia on urethral function

Original Article

Monarc vs TVT-O for the treatment of primary stress incontinence: a randomized study

Original Article

Will hysterectomy at the time of sacrocolpopexy increase the rate of polypropylene mesh erosion?