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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-12-2013 | Retinal Disorders

Vitreous fluid and circulating levels of soluble lr11, a novel marker for progression of diabetic retinopathy

Authors: Tomoaki Shiba, Hideaki Bujo, Mao Takahashi, Yukihiro Sato, Meizi Jiang, Yuichi Hori, Takatoshi Maeno, Kohji Shirai

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2013

Abstract

Background

To evaluate the vitreous fluid levels of soluble LR11 (sLR11), a novel circulating marker for proliferative diabetic retinopathy (PDR), in patients with PDR and non-PDR (NPDR) in comparison to those in patients with non-diabetic ocular diseases.

Method

Twenty NPDR and 60 PDR cases were included. Twenty-four subjects with a macular hole were served as a control group. The sLR11 levels of vitreous fluid and serum were determined by sandwich enzyme-linked immunosorbent assay.

Results

The serum sLR11 levels in the PDR and NPDR groups were 12.3 ± 5.0 ng/ml and 10.0 ± 2.7 ng/ml, respectively. The sLR11 levels in the vitreous fluid in the PDR (17.8 ± 6.2 ng/ml) and NPDR (17.4 ± 7.1 ng/ml) groups were significantly higher than those in the control subjects (12.3 ± 4.5 ng /ml) (P = 0.0003 and P = 0.006, respectively). The vitreous fluid levels of sLR11 were not significantly different between the PDR and NPDR groups, and the levels were not significantly correlated with the serum levels of sLR11 in the patients with PDR or NPDR.

Conclusion

Vitreous fluid sLR11 level may be a novel risk factor for the early development of PDR prior to the increase in circulating levels in diabetic patients.

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Title: Vitreous fluid and circulating levels of soluble lr11, a novel marker for progression of diabetic retinopathy
Authors: Tomoaki Shiba
Hideaki Bujo
Mao Takahashi
Yukihiro Sato
Meizi Jiang
Yuichi Hori
Takatoshi Maeno
Kohji Shirai
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2013
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-013-2373-9

At a glance: The STEP trials

Springer Medicine

Vitreous fluid and circulating levels of soluble lr11, a novel marker for progression of diabetic retinopathy

Abstract

Background

Method

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Method

Results

Conclusion

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