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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-10-2020 | Vitrectomy | Retinal Disorders

Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole

Authors: Biying Qi, Yanping Yu, Qisheng You, Zengyi Wang, Jing Wang, Lingzi Liu, Wu Liu

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 10/2020

Abstract

Purpose

To explore the evolution of outer foveolar lucency (OFL) after vitrectomy and the correlation between OFL and visual acuity (VA) outcome in eyes with large idiopathic macular hole (IMH).

Methods

In this retrospective study, 244 eyes of 233 subjects with large IMH (diameter > 400 μm), who underwent vitrectomy, were included. Preoperative clinical data, postoperative optical coherence tomography (OCT) images, and VA at 1-, 4-, and 10-month visits were documented. The prevalence, incidence, and width of OFL and their correlation with postoperative VA were analyzed.

Results

The prevalence of OFL was 10.4% (24/231) at 1 month and significantly increased to 30.4% (55/181) at 4 months (P < 0.001) and 34.2% (25/73) at 10 months (P < 0.001). The incidence was 26.1% (40/153) and 22.0% (9/41) at 4 and 10 months, respectively. OFL appeared at 1 month while disappeared at 4 or 10 months in 8 eyes (50.0%). The presence of OFL at 1 month was negatively associated with IMH diameter (Nagelkerke R² = 0.06; P = 0.02). Eyes with OFL at 4 months had better VA at their 4-month visit than eyes without OFL (P = 0.02). Eyes with early-developed OFLs had better VA at 10 months than those with later-developed ones (P = 0.02). Width of OFL was not associated with postoperative VA at any point.

Conclusions

OFL is not rare in eyes with large IMH after surgery. It can occur gradually and remain during the 10-month follow-up. The presence of OFL appears to have no negative impact on the postoperative VA and it may represent the remodeling of foveal photoreceptors.

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Title: Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole
Authors: Biying Qi
Yanping Yu
Qisheng You
Zengyi Wang
Jing Wang
Lingzi Liu
Wu Liu
Publication date: 01-10-2020
Publisher: Springer Berlin Heidelberg
Keyword: Vitrectomy
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 10/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04814-5

At a glance: The STEP trials

Springer Medicine

Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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