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03-05-2024 | Type 2 Diabetes | Research

Vitamin D₃ supplementation could improve the effect of exercise training on type 2 diabetes-induced metabolic disorders via BDNF/irisin axis in elderly women

Authors: Marjan Rostamian Mashhadi, Nahid Bijeh, Amir Rashidlamir, Ali Akbar Raoof

Abstract

Objectives

Metabolic disorders are commonly linked to the process of aging and menopause. It is assumed that exercise and vitamin D (VitD) can have positive effects on the body, specifically via changes in irisin and brain-derived neurotrophic factors (BDNF) levels. This study aimed to investigate the concurrent effect of VitD₃ and exercise training on insulin resistance, memory performance, irisin, and serum BDNF in postmenopausal women with diabetes.

Methods

In this current study, a total of 40 participants were randomly divided into four groups: placebo, VitD₃, placebo with combined exercise, and VitD₃ with combined exercise (with each group consisting of n = 10). The exercise group underwent the respective treatments for a duration of 8 weeks. Before the implementation of interventions and 24 h after the last session, short-term/working memory performance, insulin, homeostatic model assessment–insulin resistance (HOMA), fasting blood glucose (FBG), cholesterol, low/high-density lipoprotein-cholesterol (LDL-C/HDL-C), triglyceride (TG), VitD₃ levels, fasting serum BDNF and irisin were measured.

Results

Our data indicated the highest reduction in HOMA, insulin, cholesterol, TG, LDL-C (P < 0.001), FBG (P < 0.01), but the highest amount of increase in irisin and BDNF (P = 0.007; P = 0.004, respectively) and Digit Span Forwards and Backwards tests (P = 0.002 and P = 0.006, respectively) in VitD₃ + combined exercise compared with the placebo group.

Conclusions

Our findings showed that the combination of VitD₃ supplementation with combined exercise, compared with mono-therapy can effectively attenuate insulin resistance, cardiovascular risk factors, and improve memory performance in postmenopausal women diagnosed with type 2 diabetes, in part due to the signaling of BDNF and irisin.

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Title: Vitamin D3 supplementation could improve the effect of exercise training on type 2 diabetes-induced metabolic disorders via BDNF/irisin axis in elderly women
Authors: Marjan Rostamian Mashhadi
Nahid Bijeh
Amir Rashidlamir
Ali Akbar Raoof
Publication date: 03-05-2024
Publisher: Springer Milan
Keywords: Type 2 Diabetes
Insulins
Insulins
Published in: Sport Sciences for Health
Print ISSN: 1824-7490
Electronic ISSN: 1825-1234
DOI: https://doi.org/10.1007/s11332-024-01204-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Vitamin D₃ supplementation could improve the effect of exercise training on type 2 diabetes-induced metabolic disorders via BDNF/irisin axis in elderly women

Abstract

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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