Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 8/2011

01-08-2011 | Head and Neck

Vitamin D status is associated with disease-free survival and overall survival time in patients with squamous cell carcinoma of the upper aerodigestive tract

Authors: Markus Gugatschka, Karl Kiesler, Barbara Obermayer-Pietsch, Andrea Groselj-Strele, Antonia Griesbacher, Gerhard Friedrich

Published in: European Archives of Oto-Rhino-Laryngology | Issue 8/2011

Login to get access

Abstract

Considerable clinical and experimental data suggest that vitamin D plays a role in pathogenesis and progression of cancer; nevertheless clinical data for head and neck squamous cell carcinoma (HNSCC) are not available. The aim of our study was to associate tumor and clinical characteristics with status of vitamin D [25-hydroxyvitamin D (25(OH)D)]. 88 patients with newly diagnosed squamous cell carcinoma of the head and neck were included in the study. A blood draw was taken at the time of diagnosis. The observation period lasted from 2006 until 2010. Results: When compared to a cohort from an epidemiological study, serum levels of 25(OH)D were significantly reduced in patients with HNSCC. We furthermore found disease-free survival, as well as overall survival times to be significantly associated with 25(OH)D levels. In conclusion, results from our study suggest an influence of vitamin D status on cancer incidence, as well as on mortality of HNSCC.
Literature
1.
Trump DL, Deeb KK, Jonson CS, Vitamin D (2010) Considerations in the continued development as an agent for cancer prevention and therapy. Cancer J 16(1):1–9PubMedCrossRef
2.
Peterlik M, Grant WB, Cross HS (2009) Calcium, vitamin D and cancer. Anticancer Res 29:3687–3698PubMed
3.
Pilz S, Tomaschitz A, Obermayer-Pietsch B, Dobnig H, Pieber TR (2009) Epidemiology of vitamin D insufficiency and cancer mortality. Anticancer Res 29:3699–3700PubMed
4.
Gugatschka M, Dobnig H, Fahrleitner-Pammer A, Pietschmann P, Kudlacek S, Strele A, Obermayer-Pietsch B (2005) Molecularly-defined lactose malabsorption, milk consumption and anthropometric differences in adult males. QJM Dec 98(12):857–863CrossRef
5.
Wehr E, Pilz S, Schweighofer N, Giuliani A, Kopera D, Pieber TR, Obermayer-Pietsch B (2009) Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol 161(4):575–582PubMedCrossRef
6.
Lipworth L, Rossi M, McLaughlin JK, Negri E, Talamini R, Levi F, Franceschi S, La Vecchia C (2009) Dietary vitamin D and cancers of the oral cavity and esophagus. Ann Oncol 9:1576–1581CrossRef
7.
Schwartz GG, Blot WJ (2006) Vitamin D status and cancer incidence and mortality: something new under the sun. J Natl Cancer Inst 98(7):428–430PubMedCrossRef
8.
Giovannucci E, Liu Y, Rimm EB, Hollis BW, Fuchs CS, Stampfer MJ, Willet WC (2006) Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 98(7):451–459PubMedCrossRef
Metadata
Title
Vitamin D status is associated with disease-free survival and overall survival time in patients with squamous cell carcinoma of the upper aerodigestive tract
Authors
Markus Gugatschka
Karl Kiesler
Barbara Obermayer-Pietsch
Andrea Groselj-Strele
Antonia Griesbacher
Gerhard Friedrich
Publication date
01-08-2011
Publisher
Springer-Verlag
Published in
European Archives of Oto-Rhino-Laryngology / Issue 8/2011
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-010-1481-y

Other articles of this Issue 8/2011

European Archives of Oto-Rhino-Laryngology 8/2011 Go to the issue

Short Communication

Drug-induced sleep endoscopy: the VOTE classification

Rhinology

Paranasal sinuses computed tomography in the initial evaluation of patients with suspected invasive fungal rhinosinusitis

Rhinology

Hydroxyproline levels in nasal polyps

Head and Neck

Expression of CD34 and CD105 as markers for angiogenesis in oral vascular malformations and pyogenic granulomas

Review Article

Prevalence of age-related hearing loss in Europe: a review

Laryngology

Double probe pH-monitoring findings in patients with benign lesions of the true vocal folds: comparison with typical GERD and the effect of smoking