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01-07-2015 | Original Article

Vitamin D status in men with psoriatic arthritis: a case-control study

Authors: Z. Petho, E. Kulcsar-Jakab, E. Kalina, A. Balogh, A. Pusztai, K. Gulyas, A. Horvath, Z. Szekanecz, H. P. Bhattoa

Published in: Osteoporosis International | Issue 7/2015

Abstract

Summary

We determined hypovitaminosis D prevalence in men with psoriatic arthritis. This is a cross-sectional, analyst blinded, age- and sex-matched, case-control study. Men with psoriatic arthritis have significantly lower 25-hydroxyvitamin D levels. Men with psoriatic arthritis are at increased odds of suffering from hypovitaminosis D.

Introduction

Skeletal manifestations as a result of abrupted bone metabolism may be predominant in psoriatic arthritis (PsA). Vitamin D plays a vital role in maintenance of skeletal health and is known to modulate the immune system in various autoimmune diseases including PsA. The aim of the present study was to determine the prevalence of hypovitaminosis D in a treatment naïve, de novo psoriatic arthritis male cohort in a cross-sectional, analyst blinded, age- and sex-matched, case-control study.

Methods

25 hydroxyvitamin D (25OHD), parathyroid (PTH), osteocalcin (OC) and C-terminal telopeptides of type-I collagen (CTx) levels, and lumbar spine and femoral neck bone mineral density were compared between 53 PsA and controls.

Results

The prevalence of hypovitaminosis D (25 hydroxyvitamin D (25OHD) levels <75 nmol/L) was 81 and 57 % in the PsA and control groups, respectively. Compared to the healthy controls, 25OHD (67.2 (12–137) nmol/L vs. 51.9 (15–95) nmol/L; p = 0.001) was significantly lower, and osteocalcin (13.6 (5–33) μg/L vs. 18.2 (6–35) μg/L; p = 0.003) and C-terminal telopeptides of type-I collagen (0.20 (0.01–0.71) μg/L vs. 0.28 (0.06–0.69) μg/L; p = 0.008) were significantly higher in the PsA group. A significant association was found between hypovitaminosis D and PsA; the odds for patients with PsA of having hypovitaminosis D was 3.297 (95 % confidence interval 1.372 to 7.922).

Conclusion

The results of this study suggest that men with PsA have significantly lower 25-hydroxyvitamin D levels, and furthermore, men with PsA are at statistically significant increased odds of suffering from hypovitaminosis D.

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Title: Vitamin D status in men with psoriatic arthritis: a case-control study
Authors: Z. Petho
E. Kulcsar-Jakab
E. Kalina
A. Balogh
A. Pusztai
K. Gulyas
A. Horvath
Z. Szekanecz
H. P. Bhattoa
Publication date: 01-07-2015
Publisher: Springer London
Published in: Osteoporosis International / Issue 7/2015
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-015-3069-2

At a glance: The STEP trials

Springer Medicine

Vitamin D status in men with psoriatic arthritis: a case-control study

Abstract

Summary

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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