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Pediatric Nephrology

Published in:

01-08-2012 | Original Article

Vitamin D status in children with chronic kidney disease

Authors: Deborah R. Stein, Henry A. Feldman, Catherine M. Gordon

Published in: Pediatric Nephrology | Issue 8/2012

Abstract

Background

The role of vitamin D status in patients with renal insufficiency and its relation to dietary intake and parathyroid hormone (PTH) secretion is of utmost interest given the morbidity and mortality associated with the disordered mineral metabolism seen in chronic kidney disease (CKD).

Methods

We conducted a cross-sectional study of 100 pediatric patients with a diagnosis of CKD stage 1–5 at Children's Hospital Boston, measuring blood levels of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)₂D], and parathyroid hormone and obtaining data on nutrient intake and other variables related to vitamin D status.

Results

Subjects ranged in age from 6 months to 18 years, and 60 were male, 40 female. Of the 100 patients, 16 % were deficient in 25(OH)D (≤20 ng/mL) and another 24 % were insufficient (≤30 ng/mL), with 40 % in the suboptimal range. Serum 25(OH)D and dietary vitamin D intake were not correlated.

Conclusions

We found a high prevalence of hyperparathyroidism in early-stage CKD and a significant relationship between 25(OH)D and PTH regardless of calcitriol level. Our study results support the suggestion that optimization of vitamin D levels may provide additional benefit in preventing or improving hyperparathyroidism in patients with early CKD and likely remains important as an adjunctive therapy in children with advanced CKD.

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Title: Vitamin D status in children with chronic kidney disease
Authors: Deborah R. Stein
Henry A. Feldman
Catherine M. Gordon
Publication date: 01-08-2012
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 8/2012
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2143-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Vitamin D status in children with chronic kidney disease

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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