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Archives of Osteoporosis
Published in: Archives of Osteoporosis 1/2016

01-12-2016 | Original Article

Vitamin D status and parathyroid hormone levels in relation to bone mineral density in apparently healthy Syrian adults

Authors: Rima Sayed-Hassan, Nizar Abazid, Abir Koudsi, Zaynab Alourfi

Published in: Archives of Osteoporosis | Issue 1/2016

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Abstract

Summary

Vitamin D deficiency was highly prevalent in this study. More than half of the participants with vitamin D level less than 5 ng/mL had secondary hyperparathyroidism, which implicated a major bone health concern. After adjustment for potential predictors, parathyroid hormone (PTH) explained about 3 % of the variance in total hip bone mineral density (BMD).

Purpose

Bone mineral density (BMD) is known to be influenced by serum 25-hydroxyvitamin D (25OHD) and intact parathyroid hormone (PTH) levels. The relationship between 25OHD and PTH with BMD has not been well documented in Syrian adults. We aimed to determine how differences in serum 25OHD and PTH levels impacted hip and lumbar spine BMD among apparently healthy Syrian adults.

Methods

25OHD and PTH were measured in 156 participants aged 18–53 years from Damascus and its surroundings. Lumbar spine and hip BMD measurements were measured by dual-energy X-ray absorptiometry using Hologic Discovery Wi densitometer. Multivariate regression models were used to investigate the relationships between 25OHD, PTH, and BMD.

Results

All participants, except one male, had 25OHD <30 ng/mL (<75 nmol/L), and 89.1 % of them had 25OHD levels less than 20 ng/mL (50 nmol/L). Secondary hyperparathyroidism was significantly more prevalent in the lowest 25OHD quartile compared to that in the highest quartile (59 vs. 10.3 %, p < 0.0001). Mean bone mineral density at all sites in our participants was lower when compared to that of their Caucasian counterparts in Europe and North America. No significant correlation was found between 25OHD and BMD either at hip or at lumbar spine. In the multivariate analyses, after adjustment for potential predictors, PTH explained about 3 % of the variation in total hip BMD.

Conclusions

Low BMD was relatively frequent at all measured sites. PTH, but not 25OHD, was a predictor for total hip BMD in a young population.
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Metadata
Title
Vitamin D status and parathyroid hormone levels in relation to bone mineral density in apparently healthy Syrian adults
Authors
Rima Sayed-Hassan
Nizar Abazid
Abir Koudsi
Zaynab Alourfi
Publication date
01-12-2016
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2016
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-015-0245-0

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