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European Spine Journal

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01-01-2017 | Original Article

Vitamin D receptor gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis

Authors: Hua Jiang, Zhilin Qin, Shaohui Zong, Maolin He, Xinli Zhan, Zengming Xiao, Qingjun Wei

Published in: European Spine Journal | Issue 1/2017

Abstract

Purpose

To examine the association between Vitamin D receptor (VDR) gene polymorphisms and lumbar disc degeneration (LDD) predisposition.

Methods

A comprehensive literature search was conducted to identify all the relevant studies. The allele/genotype frequencies were extracted from each study. We calculated the pooled odds ratios (ORs) and 95 % confidence intervals (CI) to assess the strength of the association between the VDR gene polymorphisms and LDD risk. Statistical analysis was performed using RevMan 5.31 software.

Results

A total of 23 case–control studies (1835 cases and 1923 controls) were included in this systematic review. For the TaqI (rs731236), FokI (rs2228570) and ApaI (rs7975232) polymorphisms of VDR gene, nine studies, seven studies, and five studies, were eventually included in the meta-analysis, respectively. There was no evidence that the VDR gene polymorphisms (TaqI, FokI, ApaI) had significant associations with LDD risk.(for TaqI allelic comparison, OR = 1.07, 95 % CI 0.81–1.40, p = 0.64; for FokI allelic comparison, OR = 1.23, 95 % CI 0.83–1.82, p = 0.31; for ApaI allelic comparison, OR = 0.79, 95 % CI 0.55–1.14, p = 0.20). For stratified analyses by ethnicity and study design, no significant associations were found in Caucasian population and Asian population, as well as the population-based studies and hospital-based studies under all genetic models.

Conclusions

TaqI, FokI, and ApaI polymorphisms of VDR gene were not significantly associated with the predisposition of LDD. Large-scale and well-designed international studies are needed to further analyze this field.

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Title: Vitamin D receptor gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis
Authors: Hua Jiang
Zhilin Qin
Shaohui Zong
Maolin He
Xinli Zhan
Zengming Xiao
Qingjun Wei
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: European Spine Journal / Issue 1/2017
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-016-4771-2

At a glance: The STEP trials

Springer Medicine

Vitamin D receptor gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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