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Cancer Causes & Control

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14-09-2023 | Vitamin D Deficiency | Original Paper

Vitamin D and monoclonal gammopathy of undetermined significance (MGUS) among U.S. Black women

Authors: Jorge N. Ruiz Lopez, Grace E. McNeil, Gary Zirpoli, Julie R. Palmer, Yachana Kataria, Kimberly A. Bertrand

Published in: Cancer Causes & Control | Issue 2/2024

Abstract

Purpose

Risk factors for monoclonal gammopathy of undetermined significance (MGUS), the asymptomatic precursor to multiple myeloma, are largely unknown. We hypothesized that low vitamin D levels might be associated with higher MGUS prevalence in a national cohort of U.S. Black women.

Methods

We screened archived serum samples (collected 2014–2017) from 3896 randomly selected participants in the Black Women’s Health Study ages 50–79 for evidence of MGUS; samples had been assayed for 25-hydroxyvitamin D [25(OH)D] shortly after blood draw. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between 25(OH)D level and MGUS status, adjusting for age, body mass index, and season of blood draw.

Results

We identified 334 MGUS cases (8.6%) in the study population. The adjusted OR comparing women with vitamin D deficiency (25(OH)D < 20 ng/mL) to those with 25(OH)D levels ≥ 30 ng/mL was 1.27 (95% CI: 0.95, 1.72).

Conclusion

MGUS was more prevalent among Black women with vitamin D deficiency compared to those with 25(OH)D ≥ 30 ng/mL; however, the association was not statistically significant. Future prospective studies are warranted to clarify the possible association between vitamin D and MGUS.

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Title: Vitamin D and monoclonal gammopathy of undetermined significance (MGUS) among U.S. Black women
Authors: Jorge N. Ruiz Lopez
Grace E. McNeil
Gary Zirpoli
Julie R. Palmer
Yachana Kataria
Kimberly A. Bertrand
Publication date: 14-09-2023
Publisher: Springer International Publishing
Keywords: Vitamin D Deficiency
Multiple Myeloma
Published in: Cancer Causes & Control / Issue 2/2024
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-023-01798-5

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Abstract

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