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Published in: European Radiology 12/2004

01-12-2004 | Cardiac

Visual estimation of the global myocardial extent of hyperenhancement on delayed contrast-enhanced MRI

Authors: Alexandre Comte, Alain Lalande, Paul M. Walker, Alexandre Cochet, Louis Legrand, Yves Cottin, Jean-Eric Wolf, François Brunotte

Published in: European Radiology | Issue 12/2004

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Abstract

MRI with paramagnetic contrast agent allows the assessment of the extent of myocardial tissue injury after infarction. Visual segmental scoring has been widely used to define the transmural extent of myocardial infarction, but no attempt has been made to use visual scores in order to assess the percentage of the whole myocardium infarcted. By summing all the segmental scores using a 17-segment model, a global index of the size of the infarcted myocardium is easily obtained. The entire left ventricle of 60 patients with a recent myocardial infarction was scanned using an ECG-gated gradient echo sequence after injection of gadolinium contrast agent. The global score was defined as the sum of the scores on each segment, and expressed as a percentage of the maximum possible score. This index was compared with a planimetric evaluation of hyperenhancement, expressed as a percentage of the left ventricle myocardial volume. There is a good correlation between the two methods (r=0.91; y=1.06x+0.20), and the Bland-Altman plot shows a high concordance between the two approaches (mean of the differences =1.45%). A visual approach based on a 17-segment model can be used to evaluate the global myocardial extent of the hyperenhancement with similar results to planimetry.
Literature
1.
go back to reference Gibbons RJ, Verani MS, Behrenbeck T, Pellikka PA, O’Connor MK, Mahmarian JJ, Chesebro JH, Wackers FJ (1989) Feasibility of tomographic 99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction. Circulation 80:1277–1286PubMed Gibbons RJ, Verani MS, Behrenbeck T, Pellikka PA, O’Connor MK, Mahmarian JJ, Chesebro JH, Wackers FJ (1989) Feasibility of tomographic 99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction. Circulation 80:1277–1286PubMed
2.
go back to reference Christian TF, Behrenbeck T, Gersh BJ, Gibbons RJ (1991) Relation of left ventricular volume and function over one year after acute myocardial infarction to infarct size determined by technetium-99m sestamibi. Am J Cardiol 68:21–26CrossRefPubMed Christian TF, Behrenbeck T, Gersh BJ, Gibbons RJ (1991) Relation of left ventricular volume and function over one year after acute myocardial infarction to infarct size determined by technetium-99m sestamibi. Am J Cardiol 68:21–26CrossRefPubMed
3.
go back to reference Dendale P, Franken PR, Block P, Pratikakis Y, De Roos A (1998) Contrast enhanced and functional magnetic resonance imaging for the detection of viable myocardium after infarction. Am Heart J 135:875–880PubMed Dendale P, Franken PR, Block P, Pratikakis Y, De Roos A (1998) Contrast enhanced and functional magnetic resonance imaging for the detection of viable myocardium after infarction. Am Heart J 135:875–880PubMed
4.
go back to reference Kim RJ, Chen E-L, Lima JAC, Judd RM (1996) Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction. Circulation 94:3318–3326PubMed Kim RJ, Chen E-L, Lima JAC, Judd RM (1996) Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction. Circulation 94:3318–3326PubMed
5.
go back to reference Kim RJ, Fieno DS, Parrish TB, Harris K, Chen E-L, Simonetti O, Bundy J, Finn P, Klocke FJ, Judd RM (1999) Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 100:1992–2002PubMed Kim RJ, Fieno DS, Parrish TB, Harris K, Chen E-L, Simonetti O, Bundy J, Finn P, Klocke FJ, Judd RM (1999) Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 100:1992–2002PubMed
6.
go back to reference Kim RJ, Wu E, Rafael A, Chen EL, Parker MA, Simonetti O, Kloche FJ, Bonow RO, Judd RM (2000) The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med 343:1445–1453CrossRefPubMed Kim RJ, Wu E, Rafael A, Chen EL, Parker MA, Simonetti O, Kloche FJ, Bonow RO, Judd RM (2000) The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med 343:1445–1453CrossRefPubMed
7.
go back to reference Gerber BL, Garot J, Bluemke DA, Wu KC, Lima JA (2002) Accuracy of contrast-enhanced magnetic resonance imaging in predicting improvement of regional myocardial function in patients after acute myocardial infarction. Circulation 106:1083–1089CrossRefPubMed Gerber BL, Garot J, Bluemke DA, Wu KC, Lima JA (2002) Accuracy of contrast-enhanced magnetic resonance imaging in predicting improvement of regional myocardial function in patients after acute myocardial infarction. Circulation 106:1083–1089CrossRefPubMed
8.
go back to reference Lima JAC, Judd RM, Bazille A, Schulman SP, Atalar E, Zerhouni EA (1995) Regional heterogeneity of human myocardial infarcts demonstrated by contrast-enhanced MRI. Potential mechanisms. Circulation 92:1117–1125PubMed Lima JAC, Judd RM, Bazille A, Schulman SP, Atalar E, Zerhouni EA (1995) Regional heterogeneity of human myocardial infarcts demonstrated by contrast-enhanced MRI. Potential mechanisms. Circulation 92:1117–1125PubMed
9.
go back to reference Lipton MJ, Bogaert J, Boxt LM, Reba RC (2002) Imaging of ischemic heart disease. Eur Radiol 12:1061–1080CrossRefPubMed Lipton MJ, Bogaert J, Boxt LM, Reba RC (2002) Imaging of ischemic heart disease. Eur Radiol 12:1061–1080CrossRefPubMed
10.
go back to reference Sandstede JJ, Lipke C, Beer M, Harre K, Pabst T, Kenn W, Neubauer S, Hahn D (2000) Analysis of first-pass and delayed contrast-enhancement patterns of dysfunctional myocardium on MR imaging: use in prediction of myocardial viability. Am J Roentgenol 174:1737–1740 Sandstede JJ, Lipke C, Beer M, Harre K, Pabst T, Kenn W, Neubauer S, Hahn D (2000) Analysis of first-pass and delayed contrast-enhancement patterns of dysfunctional myocardium on MR imaging: use in prediction of myocardial viability. Am J Roentgenol 174:1737–1740
11.
go back to reference Sandstede JJW (2003) Assessment of myocardial viability by MR imaging. Eur Radiol 13:52–61PubMed Sandstede JJW (2003) Assessment of myocardial viability by MR imaging. Eur Radiol 13:52–61PubMed
12.
go back to reference Beek AM, Kuhl HP, Bondarenko O, Twisk JW, Hofman MB, van Dockum WG, Visser CA, van Rossum AC (2003) Delayed contrast-enhanced magnetic resonance imaging for the prediction of regional functional improvement after acute myocardial infarction. J Am Coll Cardiol 42:895–901CrossRefPubMed Beek AM, Kuhl HP, Bondarenko O, Twisk JW, Hofman MB, van Dockum WG, Visser CA, van Rossum AC (2003) Delayed contrast-enhanced magnetic resonance imaging for the prediction of regional functional improvement after acute myocardial infarction. J Am Coll Cardiol 42:895–901CrossRefPubMed
13.
go back to reference Miller S, Helber U, Brechtel K, Nagele T, Hahn U, Kramer U, Hoffmeister HM, Claussen CD (2003) MR imaging at rest early after myocardial infarction: detection of preserved function in regions with evidence for ischemic injury and non-transmural myocardial infarction. Eur Radiol 13:498–506PubMed Miller S, Helber U, Brechtel K, Nagele T, Hahn U, Kramer U, Hoffmeister HM, Claussen CD (2003) MR imaging at rest early after myocardial infarction: detection of preserved function in regions with evidence for ischemic injury and non-transmural myocardial infarction. Eur Radiol 13:498–506PubMed
14.
go back to reference Mahrholdt H, Wagner A, Holly TA, Elliott MD, Bonow RO, Kim RJ, Judd RM (2002) Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging. Circulation 106:2322–2327CrossRefPubMed Mahrholdt H, Wagner A, Holly TA, Elliott MD, Bonow RO, Kim RJ, Judd RM (2002) Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging. Circulation 106:2322–2327CrossRefPubMed
15.
go back to reference Ramani K, Judd RM, Holly TA, Parrish TB, Rigolin VH, Parker MA, Callahan C, Fitzgerald SW, Bonow RO, Klocke FJ (1998) Contrast magnetic resonance imaging in the assessment of myocardial viability in patients with stable coronary artery disease and left ventricular dysfunction. Circulation 98:2687–2694PubMed Ramani K, Judd RM, Holly TA, Parrish TB, Rigolin VH, Parker MA, Callahan C, Fitzgerald SW, Bonow RO, Klocke FJ (1998) Contrast magnetic resonance imaging in the assessment of myocardial viability in patients with stable coronary artery disease and left ventricular dysfunction. Circulation 98:2687–2694PubMed
16.
go back to reference Klein C, Nekolla SG, Bengel FM, Momose M, Sammer A, Haas F, Schnackenburg B, Delius W, Mudra H, Wolfram D, Schwaiger M (2002) Assessment of myocardial viability with contrast-enhanced magnetic resonance imaging: comparison with positron emission tomography. Circulation 105:162–167CrossRefPubMed Klein C, Nekolla SG, Bengel FM, Momose M, Sammer A, Haas F, Schnackenburg B, Delius W, Mudra H, Wolfram D, Schwaiger M (2002) Assessment of myocardial viability with contrast-enhanced magnetic resonance imaging: comparison with positron emission tomography. Circulation 105:162–167CrossRefPubMed
17.
go back to reference Wu E, Judd RM, Vargas JD, Klocke FJ, Bonow RO, Kim RJ (2001) Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction. Lancet 357:21–28CrossRefPubMed Wu E, Judd RM, Vargas JD, Klocke FJ, Bonow RO, Kim RJ (2001) Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction. Lancet 357:21–28CrossRefPubMed
18.
go back to reference Wagner A, Mahrholdt H, Holly TA, Elliott MD, Regenfus M, Parker M, Klocke FJ, Bonow RO, Kim RJ, Judd RM (2003) Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet 361:374–379CrossRefPubMed Wagner A, Mahrholdt H, Holly TA, Elliott MD, Regenfus M, Parker M, Klocke FJ, Bonow RO, Kim RJ, Judd RM (2003) Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet 361:374–379CrossRefPubMed
19.
go back to reference Choi KM, Kim RJ, Gubernikoff G, Vargas JD, Parker M, Judd RM (2001) Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function. Circulation 104:1101–1107PubMed Choi KM, Kim RJ, Gubernikoff G, Vargas JD, Parker M, Judd RM (2001) Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function. Circulation 104:1101–1107PubMed
20.
go back to reference Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. Circulation 105:539–542CrossRefPubMed Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. Circulation 105:539–542CrossRefPubMed
21.
go back to reference Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 8:307–310 Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 8:307–310
22.
go back to reference Fieno DS, Kim RJ, Chen EL, Lomasney JW, Kloche FJ, Judd RM (2000) Contrast-enhanced magnetic resonance imaging of myocardium at risk: distinction between reversible and irreversible injury throughout infarct healing. J Am Coll Cardiol 36:1985–1991CrossRefPubMed Fieno DS, Kim RJ, Chen EL, Lomasney JW, Kloche FJ, Judd RM (2000) Contrast-enhanced magnetic resonance imaging of myocardium at risk: distinction between reversible and irreversible injury throughout infarct healing. J Am Coll Cardiol 36:1985–1991CrossRefPubMed
23.
go back to reference Henry WL, DeMaria A, Gramiak R, King DL, Kisslo JA, Popp RL, Sahn DJ, Schiller NB, Tajik A, Teichholz LE, Weyman AE (1980) Report of the American society of echocardiography committee on nomenclature and standards in two-dimensional echocardiography. Circulation 62:212–217PubMed Henry WL, DeMaria A, Gramiak R, King DL, Kisslo JA, Popp RL, Sahn DJ, Schiller NB, Tajik A, Teichholz LE, Weyman AE (1980) Report of the American society of echocardiography committee on nomenclature and standards in two-dimensional echocardiography. Circulation 62:212–217PubMed
24.
go back to reference Gibbons RJ, Miller TD, Christian TF (2000) Infarct size measured by single photon emission computed tomographic imaging with (99m)Tc-sestamibi: a measure of the efficacy of therapy in acute myocardial infarction. Circulation 101:101–108PubMed Gibbons RJ, Miller TD, Christian TF (2000) Infarct size measured by single photon emission computed tomographic imaging with (99m)Tc-sestamibi: a measure of the efficacy of therapy in acute myocardial infarction. Circulation 101:101–108PubMed
25.
go back to reference Miller TD, Christian TF, Hopfenspirger MR, Hodge DO, Gersh BJ, Gibbons RJ (1995) Infarct size after acute myocardial infarction measured by quantitative tomographic 99mTc sestamibi imaging predicts subsequent mortality. Circulation 92:334–341PubMed Miller TD, Christian TF, Hopfenspirger MR, Hodge DO, Gersh BJ, Gibbons RJ (1995) Infarct size after acute myocardial infarction measured by quantitative tomographic 99mTc sestamibi imaging predicts subsequent mortality. Circulation 92:334–341PubMed
26.
go back to reference Udelson JE, Coleman PS, Metherall J, Pandian NG, Gomez AR, Griffith JL, Shea NL, Oates E, Konstam MA (1994) Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201Tl and 99mTc-sestamibi. Circulation 89:2552–2561PubMed Udelson JE, Coleman PS, Metherall J, Pandian NG, Gomez AR, Griffith JL, Shea NL, Oates E, Konstam MA (1994) Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201Tl and 99mTc-sestamibi. Circulation 89:2552–2561PubMed
27.
go back to reference Berman DS, Kang X, Abidov A, Cohen I, Hayes SW, Friedman JD, Sciammarella M, Germano G, Aboul-Enein F, Hachamovitch R (2003) Prognostic value of myocardial perfusion SPECT comparing 17-segment and 20-segment scoring systems. J Am Coll Cardiol 19:445CrossRef Berman DS, Kang X, Abidov A, Cohen I, Hayes SW, Friedman JD, Sciammarella M, Germano G, Aboul-Enein F, Hachamovitch R (2003) Prognostic value of myocardial perfusion SPECT comparing 17-segment and 20-segment scoring systems. J Am Coll Cardiol 19:445CrossRef
Metadata
Title
Visual estimation of the global myocardial extent of hyperenhancement on delayed contrast-enhanced MRI
Authors
Alexandre Comte
Alain Lalande
Paul M. Walker
Alexandre Cochet
Louis Legrand
Yves Cottin
Jean-Eric Wolf
François Brunotte
Publication date
01-12-2004
Publisher
Springer-Verlag
Published in
European Radiology / Issue 12/2004
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-004-2483-1

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