Effect modification in a clinical trial should be assessed through interaction terms, not prognostic modelling

go back to reference Piton G, Le Gouge A, Boisrame-Helms J, Anguel N, Argaud L, Asfar P, Botoc V, Bretagnol A, Brisard L, Bui HN, Canet E, Chatelier D, Chauvelot L, Darmon M, Das V, Devaquet J, Djibre M, Ganster F, Garrouste-Orgeas M, Gaudry S, Gontier O, Groyer S, Guidet B, Herbrecht JE, Hourmant Y, Lacherade JC, Letocart P, Martino F, Maxime V, Mercier E, Mira JP, Nseir S, Quenot JP, Richecoeur J, Rigaud JP, Roux D, Schnell D, Schwebel C, Silva D, Sirodot M, Souweine B, Thieulot-Rolin N, Tinturier F, Tirot P, Thevenin D, Thiery G, Lascarrou JB, Reignier J, Clinical Research in Intensive C, Sepsis G (2022) Factors associated with acute mesenteric ischemia among critically ill ventilated patients with shock: a post hoc analysis of the NUTRIREA2 trial. Intensive Care Med 48:458–466CrossRef Piton G, Le Gouge A, Boisrame-Helms J, Anguel N, Argaud L, Asfar P, Botoc V, Bretagnol A, Brisard L, Bui HN, Canet E, Chatelier D, Chauvelot L, Darmon M, Das V, Devaquet J, Djibre M, Ganster F, Garrouste-Orgeas M, Gaudry S, Gontier O, Groyer S, Guidet B, Herbrecht JE, Hourmant Y, Lacherade JC, Letocart P, Martino F, Maxime V, Mercier E, Mira JP, Nseir S, Quenot JP, Richecoeur J, Rigaud JP, Roux D, Schnell D, Schwebel C, Silva D, Sirodot M, Souweine B, Thieulot-Rolin N, Tinturier F, Tirot P, Thevenin D, Thiery G, Lascarrou JB, Reignier J, Clinical Research in Intensive C, Sepsis G (2022) Factors associated with acute mesenteric ischemia among critically ill ventilated patients with shock: a post hoc analysis of the NUTRIREA2 trial. Intensive Care Med 48:458–466CrossRef

go back to reference Iapichino G, Radrizzani D, Zanello M, Tetamo R, Buono S (2022) Enteral nutrition and acute mesenteric ischemia. Intensive Care Med. https://doi.org/10.1007/s00134-022-06689-yCrossRefPubMed Iapichino G, Radrizzani D, Zanello M, Tetamo R, Buono S (2022) Enteral nutrition and acute mesenteric ischemia. Intensive Care Med. https://​doi.​org/​10.​1007/​s00134-022-06689-yCrossRefPubMed

go back to reference Piton G, Le Gouge A, Reignier J (2022) Full enteral nutrition should be avoided among patients with high vasopressor dose and low flow state. Intensive Care Med. https://doi.org/10.1007/s00134-022-06703-3CrossRefPubMedPubMedCentral Piton G, Le Gouge A, Reignier J (2022) Full enteral nutrition should be avoided among patients with high vasopressor dose and low flow state. Intensive Care Med. https://​doi.​org/​10.​1007/​s00134-022-06703-3CrossRefPubMedPubMedCentral

go back to reference Reignier J, Boisrame-Helms J, Brisard L, Lascarrou JB, Ait Hssain A, Anguel N, Argaud L, Asehnoune K, Asfar P, Bellec F, Botoc V, Bretagnol A, Bui HN, Canet E, Da Silva D, Darmon M, Das V, Devaquet J, Djibre M, Ganster F, Garrouste-Orgeas M, Gaudry S, Gontier O, Guerin C, Guidet B, Guitton C, Herbrecht JE, Lacherade JC, Letocart P, Martino F, Maxime V, Mercier E, Mira JP, Nseir S, Piton G, Quenot JP, Richecoeur J, Rigaud JP, Robert R, Rolin N, Schwebel C, Sirodot M, Tinturier F, Thevenin D, Giraudeau B, Le Gouge A, Investigators N-T, Clinical Research in Intensive C, Sepsis G (2018) Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2). Lancet 391:133–143CrossRef Reignier J, Boisrame-Helms J, Brisard L, Lascarrou JB, Ait Hssain A, Anguel N, Argaud L, Asehnoune K, Asfar P, Bellec F, Botoc V, Bretagnol A, Bui HN, Canet E, Da Silva D, Darmon M, Das V, Devaquet J, Djibre M, Ganster F, Garrouste-Orgeas M, Gaudry S, Gontier O, Guerin C, Guidet B, Guitton C, Herbrecht JE, Lacherade JC, Letocart P, Martino F, Maxime V, Mercier E, Mira JP, Nseir S, Piton G, Quenot JP, Richecoeur J, Rigaud JP, Robert R, Rolin N, Schwebel C, Sirodot M, Tinturier F, Thevenin D, Giraudeau B, Le Gouge A, Investigators N-T, Clinical Research in Intensive C, Sepsis G (2018) Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2). Lancet 391:133–143CrossRef

go back to reference Compher C, Bingham AL, McCall M, Patel J, Rice TW, Braunschweig C, McKeever L (2022) Guidelines for the provision of nutrition support therapy in the adult critically ill patient: the American Society for Parenteral and Enteral Nutrition. JPEN J Parenter Enteral Nutr 46:12–41CrossRef Compher C, Bingham AL, McCall M, Patel J, Rice TW, Braunschweig C, McKeever L (2022) Guidelines for the provision of nutrition support therapy in the adult critically ill patient: the American Society for Parenteral and Enteral Nutrition. JPEN J Parenter Enteral Nutr 46:12–41CrossRef