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01-12-2024 | Vestibular Schwannoma | Case Report

Malignant transformation of vestibular schwannoma following radiosurgery—a case report and review of the literature

Authors: Arthur Hosmann, Vatsal Kamdar, Basant K Misra

Published in: Acta Neurochirurgica | Issue 1/2024

Abstract

Malignant transformation of vestibular schwannoma (VS) post-radiosurgery is an extremely rare but life-threatening complication. We present a patient who underwent two surgeries for a benign VS and received Gamma Knife radiosurgery for residual tumour. Five and a half years post-radiosurgery, the patient was reoperated for symptomatic recurrence of the tumour. Histopathology confirmed the diagnosis of a high-grade spindle cell sarcoma. Although near-total resection was uneventful, the patient deteriorated rapidly, and comfort care was chosen. This report is the 13th documented case of histopathologically confirmed malignant transformation of a benign VS that strictly meets the modified Cahan’s criteria, suggesting the direct link to radiosurgery-induced malignancy.

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Title: Malignant transformation of vestibular schwannoma following radiosurgery—a case report and review of the literature
Authors: Arthur Hosmann
Vatsal Kamdar
Basant K Misra
Publication date: 01-12-2024
Publisher: Springer Vienna
Keywords: Vestibular Schwannoma
Vestibular Schwannoma
Sarcoma
Published in: Acta Neurochirurgica / Issue 1/2024
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-024-05921-6

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Malignant transformation of vestibular schwannoma following radiosurgery—a case report and review of the literature

Abstract

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