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BMC Infectious Diseases

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Open Access 01-12-2022 | Venous Thrombosis | Case report

Septicaemia with deep venous thrombosis and necrotising pneumonia caused by acute community-acquired methicillin-resistant Staphylococcus aureus in an infant with a three-year follow-up: a case report

Authors: Mei Lu, Meijiao Fu, Yanhong Zhang, Tong Shen, Hui Xie, Dengli Liu

Published in: BMC Infectious Diseases | Issue 1/2022

Abstract

Background

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a common pathogen that usually causes bacteraemia, osteomyelitis, as well as skin and soft tissue infections. However, deep venous thrombosis (DVT) and necrotising pneumonia are rare in infants.

Case presentation

We report the case of a one-month-five-day-old girl who was hospitalised for DVT and necrotising pneumonia due to septicaemia associated with Staphylococcus aureus. She recovered after treatment with intravenous antibiotics and multiple anticoagulant therapy, but DVT persisted at the three-year follow-up. Collateral circulation around the DVT was well-formed. Post thrombotic syndrome was not observed.

Conclusions

Staphylococcus aureus complicated by DVT and necrotising pneumonia is rare and can be successfully treated.

Andrew M, David M, Adams M, Ali K, Anderson R, Barnard D, et al. Venous thromboembolic complications (VTE) in children: first analyses of the Canadian registry of VTE. Blood. 1994;83:1251–7.CrossRef

van Ommen CH, Heijboer H, Büller HR, Hirasing RA, Heijmans HS, Peters M. Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands. J Pediatr. 2001;139:676–81. https://doi.org/10.1067/mpd.2001.118192.CrossRef

Gonzalez BE, Teruya J, Mahoney DH, Hulten KG, Edwards R, Lamberth LB, et al. Venous thrombosis associated with staphylococcal osteomyelitis in children. Pediatrics. 2006;117:1673–9. https://doi.org/10.1542/peds.2005-2009.CrossRefPubMed

Ridgway JM, Parikh DA, Wright R, Holden P, Armstrong W, Camilon F, et al. Lemierre syndrome: a pediatric case series and review of literature. Am J Otolaryngol. 2010;31:38–45. https://doi.org/10.1016/j.amjoto.2008.09.006.CrossRefPubMed

Abhishek A, Sandeep S, Tarun P. Lemierre syndrome from a neck abscess due to methicillin-resistant Staphylococcus aureus. Braz J Infect Dis. 2013;17:507–9. https://doi.org/10.1016/j.bjid.2012.11.010.CrossRefPubMed

Turner NA, Sharma-Kuinkel BK, Maskarinec SA, Eichenberger EM, Shah PP, Carugati M, et al. Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research. Nat Rev Microbiol. 2019;17:203–18. https://doi.org/10.1038/s41579-018-0147-4.CrossRefPubMedPubMedCentral

Francis JS, Doherty MC, Lopatin U, Johnston CP, Sinha G, Ross T, et al. Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the panton-valentine leukocidin genes. Clin Infect Dis. 2005;40(1):100–7. https://doi.org/10.1086/427148.CrossRefPubMed

Bhatta DR, Cavaco LM, Nath G, Kumar K, Gaur A, Gokhale S, et al. Association of Panton Valentine Leukocidin (PVL) genes with methicillin resistant Staphylococcus aureus (MRSA) in Western Nepal: a matter of concern for community infections (a hospital based prospective study). BMC Infect Dis. 2016;16:199. https://doi.org/10.1186/s12879-016-1531-1.CrossRefPubMedPubMedCentral

Vardakas KZ, Matthaiou DK, Falagas ME. Incidence, characteristics and outcomes of patients with severe community acquired-MRSA pneumonia. Eur Respir J. 2009;34:1148–58. https://doi.org/10.1183/09031936.00041009.CrossRefPubMed

10.

Sawicki GS, Lu FL, Valim C, Cleveland RH, Colin AA. Necrotising pneumonia is an increasingly detected complication of pneumonia in children. Eur Respir J. 2008;31:1285–91. https://doi.org/10.1183/09031936.00099807.CrossRefPubMed

11.

Otto M. Community-associated MRSA: what makes them special? Int J Med Microbiol. 2013;303:324–30. https://doi.org/10.1016/j.ijmm.2013.02.007.CrossRefPubMedPubMedCentral

12.

Otto M. Staphylococcus aureus toxins. Curr Opin Microbiol. 2014;17:32–7. https://doi.org/10.1016/j.mib.2013.11.004.CrossRefPubMed

13.

Lemaître C, Angoulvant F, Gabor F, Makhoul J, Bonacorsi S, Naudin J, et al. Necrotizing pneumonia in children: report of 41 cases between 2006 and 2011 in a French tertiary care center. Pediatr Infect Dis J. 2013;32:1146–9. https://doi.org/10.1097/INF.0b013e31829be1bb.CrossRefPubMed

14.

Hoppe PA, Holzhauer S, Lala B, Bührer C, Gratopp A, Hanitsch LG, et al. Severe infections of Panton-Valentine leukocidin positive Staphylococcus aureus in children. Medicine. 2019;98: e17185. https://doi.org/10.1097/MD.0000000000017185.CrossRefPubMedPubMedCentral

15.

Nourse C, Starr M, Munckhof W. Community-acquired methicillin-resistant Staphylococcus aureus causes severe disseminated infection and deep venous thrombosis in children: literature review and recommendations for management. J Paediatr Child Health. 2007;43:656–61. https://doi.org/10.1111/j.1440-1754.2007.01153.x.CrossRefPubMed

16.

Monagle P, Chan AKC, Goldenberg NA, Ichord RN, Journeycake JM, Nowak-Göttl U, et al. Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis, 9th edn, American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e737S–e801S.

17.

Sandoval JA, Sheehan MP, Stonerock CE, Shafique S, Rescorla FJ, Dalsing MC. Incidence, risk factors, and treatment patterns for deep venous thrombosis in hospitalized children: an increasing population at risk. J Vasc Surg. 2008;47:837–43. https://doi.org/10.1016/j.jvs.2007.11.054.CrossRefPubMed

18.

Sridhar DC, Maher OM, Rodriguez NI. Pediatric deep venous thrombosis associated with Staphylococcal infections: single institutional experience. J Pediatr Hematol Oncol. 2018;40:e73–6. https://doi.org/10.1097/MPH.0000000000001040.CrossRef

19.

Li X, Zhang F, Wang S. Guidelines for the diagnosis and treatment of deep vein thrombosis. Chin J Vasc Surg. 2017;9:250–7. https://doi.org/10.3969/j.issn.1674-7429.2017.04.003 (in Chinese).CrossRef

20.

Monagle P, Newall F. Management of thrombosis in children and neonates: practical use of anticoagulants in children. Hematol Am Soc Hematol Educ Program. 2018;2018:399–404. https://doi.org/10.1182/asheducation-2018.1.399.CrossRef

21.

Koo J, Pong A, Dory C, Farnaes L, Thornburg CD. Management and outcomes of pediatric septic thrombophlebitis: a case series. Pediatr Hematol Oncol. 2020;37:344–52. https://doi.org/10.1080/08880018.2020.1733147.CrossRefPubMed

22.

Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020;135:2033–40. https://doi.org/10.1182/blood.2020006000.CrossRefPubMed

23.

Carrier M, Le Gal G, Bates SM, Anderson DR, Wells PS. D-dimer testing is useful to exclude deep vein thrombosis in elderly outpatients. J Thromb Haemost. 2008;6:1072–6. https://doi.org/10.1111/j.1538-7836.2008.03007.x.CrossRefPubMed

24.

Kanis J, Hall CL, Pike J, Kline JA. Diagnostic accuracy of the D-dimer in children. Arch Dis Child. 2018;103:832–4. https://doi.org/10.1136/archdischild-2017-313315.CrossRefPubMed

Title: Septicaemia with deep venous thrombosis and necrotising pneumonia caused by acute community-acquired methicillin-resistant Staphylococcus aureus in an infant with a three-year follow-up: a case report
Authors: Mei Lu
Meijiao Fu
Yanhong Zhang
Tong Shen
Hui Xie
Dengli Liu
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Venous Thrombosis
Septicemia
Septicemia
Soft Tissue Infection
Pneumonia
Venous Thrombosis
Osteomyelitis
Published in: BMC Infectious Diseases / Issue 1/2022
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-022-07166-z

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Abstract

Background

Case presentation

Conclusions

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