Skip to main content
Top
Published in: Annals of Surgical Oncology 12/2019

01-11-2019 | Gastrointestinal Oncology

Venous Thromboembolism Following Abdominal Cancer Surgery in the Korean Population: Incidence and Validation of a Risk Assessment Model

Authors: Mi-hyeong Kim, MD, PhD, Kang-woong Jun, MD, Jeong-kye Hwang, MD, PhD, Sang-dong Kim, MD, PhD, Jang-yong Kim, MD, PhD, Sun-cheol Park, MD, PhD, Yong-sung Won, MD, PhD, Sang-seop Yun, MD, PhD, In-sung Moon, MD, PhD, Ji-il Kim, MD, PhD

Published in: Annals of Surgical Oncology | Issue 12/2019

Login to get access

Abstract

Background

A cancer patient slated for abdominal surgery is considered to be at moderate to high risk for developing venous thromboembolism (VTE), but the incidence is quite low in Korean patients. Most risk assessment models and recommendations for VTE management are from Western reports, however they possibly overestimate the risk of VTE in the Korean population.

Methods

We retrospectively reviewed the medical records of 1966 patients who were diagnosed with abdominal organ cancer and required surgical treatment.

Results

Each patient was rated using the Caprini risk scoring model. The mean score was 7.5 ± 0.7 points; 98.4% of patients were classified as high risk for VTE. Symptomatic VTE occurred in eight patients, and the overall incidence was 0.4%. The mean Caprini score for VTE patients was 8.8 ± 1.9 points. In the group with scores between 5 and 9 points, the incidence was 0.3–0.5%, while in patients with scores > 10 points, the incidence of VTE was found to be 1.12%.

Conclusions

The risk stratification system in the Caprini scoring model needs to be modified based on the actual incidence in the Korean population.
Literature
1.
go back to reference De Cicco M. The prothrombotic state in cancer: pathogenic mechanisms. Crit Rev Oncol Hematol. 2004;50:187–96.CrossRefPubMed De Cicco M. The prothrombotic state in cancer: pathogenic mechanisms. Crit Rev Oncol Hematol. 2004;50:187–96.CrossRefPubMed
2.
3.
go back to reference Falanga A, Marchetti M, Vignoli A. Coagulation and cancer: biologic and clinical aspects. J Thromb Haemost. 2013;11:223–33.CrossRefPubMed Falanga A, Marchetti M, Vignoli A. Coagulation and cancer: biologic and clinical aspects. J Thromb Haemost. 2013;11:223–33.CrossRefPubMed
4.
go back to reference Caprini JA. Thrombosis risk assessment as a guide to quality patient care. Dis Mon. 2005;51:70–8.CrossRefPubMed Caprini JA. Thrombosis risk assessment as a guide to quality patient care. Dis Mon. 2005;51:70–8.CrossRefPubMed
5.
go back to reference Bahl V, Hu HM, Henke PK, et al. A validation study of a retrospective venous thromboembolism risk scoring method. Ann Surg. 2010;251:344–50.CrossRefPubMed Bahl V, Hu HM, Henke PK, et al. A validation study of a retrospective venous thromboembolism risk scoring method. Ann Surg. 2010;251:344–50.CrossRefPubMed
6.
go back to reference Zhou HX, Peng LQ, Yan Y, et al. Validation of the caprini risk assessment model in Chinese hospitalized patients with venous thromboembolism. Thromb Res. 2012;130:735–40.CrossRefPubMed Zhou HX, Peng LQ, Yan Y, et al. Validation of the caprini risk assessment model in Chinese hospitalized patients with venous thromboembolism. Thromb Res. 2012;130:735–40.CrossRefPubMed
7.
go back to reference Zhou H, Wang L, Wu X, et al. Validation of a venous thromboembolism risk assessment model in hospitalized chinese patients: a case-control study. J Atheroscler Thromb. 2014;21:261–72.CrossRefPubMed Zhou H, Wang L, Wu X, et al. Validation of a venous thromboembolism risk assessment model in hospitalized chinese patients: a case-control study. J Atheroscler Thromb. 2014;21:261–72.CrossRefPubMed
8.
go back to reference Liew NC, Alemany GV, Angchaisuksiri P, et al. Asian venous thromboembolism guidelines: updated recommendations for the prevention of venous thromboembolism. Int Angiol. 2017;36:1–20.PubMed Liew NC, Alemany GV, Angchaisuksiri P, et al. Asian venous thromboembolism guidelines: updated recommendations for the prevention of venous thromboembolism. Int Angiol. 2017;36:1–20.PubMed
9.
go back to reference Lee LH, Gallus A, Jindal R, et al. Incidence of venous thromboembolism in Asian populations: a systematic review. Thromb Haemost. 2017;117:2243–60.CrossRefPubMed Lee LH, Gallus A, Jindal R, et al. Incidence of venous thromboembolism in Asian populations: a systematic review. Thromb Haemost. 2017;117:2243–60.CrossRefPubMed
10.
go back to reference Jang MJ, Bang SM, Oh D. Incidence of venous thromboembolism in Korea: from the Health Insurance Review and Assessment Service database. J Thromb Haemost. 2011;9:85–91.CrossRefPubMed Jang MJ, Bang SM, Oh D. Incidence of venous thromboembolism in Korea: from the Health Insurance Review and Assessment Service database. J Thromb Haemost. 2011;9:85–91.CrossRefPubMed
11.
go back to reference Yhim HY, Jang MJ, Bang SM, et al. Incidence of venous thromboembolism following major surgery in Korea: from the Health Insurance Review and Assessment Service database. J Thromb Haemost. 2014;12:1035–43.CrossRefPubMed Yhim HY, Jang MJ, Bang SM, et al. Incidence of venous thromboembolism following major surgery in Korea: from the Health Insurance Review and Assessment Service database. J Thromb Haemost. 2014;12:1035–43.CrossRefPubMed
12.
go back to reference Yu YB, Gau JP, Liu CY, et al. A nation-wide analysis of venous thromboembolism in 497,180 cancer patients with the development and validation of a risk-stratification scoring system. Thromb Haemost. 2012;108:225–35.CrossRefPubMed Yu YB, Gau JP, Liu CY, et al. A nation-wide analysis of venous thromboembolism in 497,180 cancer patients with the development and validation of a risk-stratification scoring system. Thromb Haemost. 2012;108:225–35.CrossRefPubMed
14.
go back to reference Law Y, Chan YC, Cheng SWK. Epidemiological updates of venous thromboembolism in a Chinese population. Asian J Surg. 2018;41:176–82.CrossRefPubMed Law Y, Chan YC, Cheng SWK. Epidemiological updates of venous thromboembolism in a Chinese population. Asian J Surg. 2018;41:176–82.CrossRefPubMed
15.
go back to reference Chew HK, Wun T, Harvey D, et al. Incidence of venous thromboembolism and its effect on survival among patients with common cancers. Arch Intern Med. 2006;166:458–64.CrossRefPubMed Chew HK, Wun T, Harvey D, et al. Incidence of venous thromboembolism and its effect on survival among patients with common cancers. Arch Intern Med. 2006;166:458–64.CrossRefPubMed
16.
go back to reference Hammond J, Kozma C, Hart JC, et al. Rates of venous thromboembolism among patients with major surgery for cancer. Ann Surg Oncol. 2011;18:3240–7.CrossRefPubMed Hammond J, Kozma C, Hart JC, et al. Rates of venous thromboembolism among patients with major surgery for cancer. Ann Surg Oncol. 2011;18:3240–7.CrossRefPubMed
17.
go back to reference Heit JA. The epidemiology of venous thromboembolism in the community: implications for prevention and management. J Thromb Thrombolysis. 2006;21:23–9.CrossRefPubMed Heit JA. The epidemiology of venous thromboembolism in the community: implications for prevention and management. J Thromb Thrombolysis. 2006;21:23–9.CrossRefPubMed
18.
go back to reference Horsted F, West J, Grainge MJ. Risk of venous thromboembolism in patients with cancer: a systematic review and meta-analysis. PLoS Med. 2012;9:e1001275.CrossRefPubMedPubMedCentral Horsted F, West J, Grainge MJ. Risk of venous thromboembolism in patients with cancer: a systematic review and meta-analysis. PLoS Med. 2012;9:e1001275.CrossRefPubMedPubMedCentral
19.
go back to reference Naess IA, Christiansen SC, Romundstad P, et al. Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost. 2007;5:692–9.CrossRefPubMed Naess IA, Christiansen SC, Romundstad P, et al. Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost. 2007;5:692–9.CrossRefPubMed
20.
go back to reference White RH, Keenan CR. Effects of race and ethnicity on the incidence of venous thromboembolism. Thromb Res. 2009;123 Suppl 4:S11–7.CrossRefPubMed White RH, Keenan CR. Effects of race and ethnicity on the incidence of venous thromboembolism. Thromb Res. 2009;123 Suppl 4:S11–7.CrossRefPubMed
21.
go back to reference Parikh KC, Oh D, Sittipunt C, et al. Venous thromboembolism prophylaxis in medical ICU patients in Asia (VOICE Asia): a multicenter, observational, cross-sectional study. Thromb Res. 2012;129:e152–8.CrossRefPubMed Parikh KC, Oh D, Sittipunt C, et al. Venous thromboembolism prophylaxis in medical ICU patients in Asia (VOICE Asia): a multicenter, observational, cross-sectional study. Thromb Res. 2012;129:e152–8.CrossRefPubMed
22.
go back to reference Gould MK, Garcia DA, Wren SM, et al. Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141:e227S–e77S.CrossRefPubMedPubMedCentral Gould MK, Garcia DA, Wren SM, et al. Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141:e227S–e77S.CrossRefPubMedPubMedCentral
23.
go back to reference Klatsky AL, Amstrong MA, Poggi J. Risk of pulmonary embolism and or deep venous thrombosis in Asian-Americans. Am J Cardiol. 2000;85:1334–7.CrossRefPubMed Klatsky AL, Amstrong MA, Poggi J. Risk of pulmonary embolism and or deep venous thrombosis in Asian-Americans. Am J Cardiol. 2000;85:1334–7.CrossRefPubMed
24.
go back to reference Ridker PM, Miletich JP, Hnnekens CH, et al. Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening. JAMA. 1997;277:1305–7.PubMed Ridker PM, Miletich JP, Hnnekens CH, et al. Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening. JAMA. 1997;277:1305–7.PubMed
25.
go back to reference Lyman GH, Bohlke K, Khorana AA, et al. Venous thromboembolism prophylaxis and treatment in patients with cancer: American Society of Clinical Oncology clinical practice guideline update 2014. J Clin Oncol. 2015;33:654–6.CrossRefPubMedPubMedCentral Lyman GH, Bohlke K, Khorana AA, et al. Venous thromboembolism prophylaxis and treatment in patients with cancer: American Society of Clinical Oncology clinical practice guideline update 2014. J Clin Oncol. 2015;33:654–6.CrossRefPubMedPubMedCentral
26.
go back to reference Streiff MB, Holmstrom B, Ashrani A, et al. Cancer-associated venous thromboembolic disease, version 1.2015. J Natl Compr Canc Netw. 2015;13:1079–95. Streiff MB, Holmstrom B, Ashrani A, et al. Cancer-associated venous thromboembolic disease, version 1.2015. J Natl Compr Canc Netw. 2015;13:1079–95.
Metadata
Title
Venous Thromboembolism Following Abdominal Cancer Surgery in the Korean Population: Incidence and Validation of a Risk Assessment Model
Authors
Mi-hyeong Kim, MD, PhD
Kang-woong Jun, MD
Jeong-kye Hwang, MD, PhD
Sang-dong Kim, MD, PhD
Jang-yong Kim, MD, PhD
Sun-cheol Park, MD, PhD
Yong-sung Won, MD, PhD
Sang-seop Yun, MD, PhD
In-sung Moon, MD, PhD
Ji-il Kim, MD, PhD
Publication date
01-11-2019
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 12/2019
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-07633-z

Other articles of this Issue 12/2019

Annals of Surgical Oncology 12/2019 Go to the issue