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Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 2/2010

Open Access 01-02-2010 | Retinal Disorders

Venous retinal flow reperfusion mechanisms following radial optic neurotomy with adjunctive intraocular triamcinolone in central retinal vein occlusion

Authors: Pina Fortunato, Liliana Pollazzi, Maurizio Baroni, Attilio Evangelisti, Agostino La Torre

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 2/2010

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Abstract

Background

To evaluate retinal reperfusion, anastomosis, and compensation following radial optic neurotomy for ischemic nonperfused central retinal vein occlusion.

Methods

Prospective, non-comparative, interventional case series of 13 patients with ischemic, nonperfused central retinal vein occlusion who underwent decompression surgery with a radial optic neurotomy and adjunctive intraocular triamcinolone. Patients were followed for 1 year after surgery, and were analyzed in the preoperative and postoperative stages determining: visual acuity by ETDRS chart (LogMar) and retinal thickness with optical coherence tomography. Fluorescein angiography was performed at regular intervals to evaluate the capillary perfusion grade. Intraocular pressure was measured and fundus was examined.

Results

Visual acuity and retinal thickness improved in 10/13 (77%) patients after surgery at 1-year follow-up. Adequate retinal reperfusion was achieved in ten of the 13 eyes. Acute reperfusion occurred in six eyes within 2 weeks of surgery and a shunt vessel at the optic disk developed in four eyes within 4 months. In the remaining three eyes, retinal reperfusion was not observed by fluorescein angiography. No complications were noted in any of the patients.

Conclusion

Surgical decompression promoted mechanical reperfusion of the occluded vessel in 10/13 (77%) cases. In 6/13 patients (46%) reperfusion occurred within 2 weeks of surgery, and in 4/13 patients (31%) collateral vessels formed within 4 months.
Literature
1.
go back to reference The Eye Disease Case-Control Study Group (1996) Risk factors for central retinal vein occlusion. Arch Ophthalmol 114:545–554 The Eye Disease Case-Control Study Group (1996) Risk factors for central retinal vein occlusion. Arch Ophthalmol 114:545–554
2.
go back to reference Rath EZ, Frank RN, Shin DH, Kim C (1992) Risk factors for retinal vein occlusions: a case-controlled study. Ophthalmology 99:509–514PubMed Rath EZ, Frank RN, Shin DH, Kim C (1992) Risk factors for retinal vein occlusions: a case-controlled study. Ophthalmology 99:509–514PubMed
3.
go back to reference Hayreh SS (1994) Retinal vein occlusion. Indian J Ophthalmol 42:109–132PubMed Hayreh SS (1994) Retinal vein occlusion. Indian J Ophthalmol 42:109–132PubMed
4.
go back to reference Hayreh SS (2005) Prevalent misconceptions about acute retinal vascular occlusive disorders. Prog Retin Eye Res 24:493–519CrossRefPubMed Hayreh SS (2005) Prevalent misconceptions about acute retinal vascular occlusive disorders. Prog Retin Eye Res 24:493–519CrossRefPubMed
5.
go back to reference Green WR, Chan CC, Hutchins GM, Terry JM (2005) Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases. Retina 25:27–55CrossRefPubMed Green WR, Chan CC, Hutchins GM, Terry JM (2005) Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases. Retina 25:27–55CrossRefPubMed
6.
go back to reference Opremcak EM, Bruce RA, Lomeo MD et al (2001) Radial optic neurotomy for central vein occlusion. Retina 21:408–415CrossRefPubMed Opremcak EM, Bruce RA, Lomeo MD et al (2001) Radial optic neurotomy for central vein occlusion. Retina 21:408–415CrossRefPubMed
7.
go back to reference Opremcak EM, Rehmar AJ, Ridenour CD, Kurz DE (2006) Radial optic neurotomy for central retinal vein occlusion. Retina 26:297–305CrossRefPubMed Opremcak EM, Rehmar AJ, Ridenour CD, Kurz DE (2006) Radial optic neurotomy for central retinal vein occlusion. Retina 26:297–305CrossRefPubMed
8.
go back to reference The Central Vein Occlusion Study Group (1997) Natural history and clinical management of central retinal vein occlusion. Arch Ophthalmol 115:486–491 The Central Vein Occlusion Study Group (1997) Natural history and clinical management of central retinal vein occlusion. Arch Ophthalmol 115:486–491
9.
go back to reference The Central Vein Occlusion Study Group N report (1995) A randomized clinical trial of early panretinal photocoagulation for ischemic central vein occlusion. Ophthalmology 102:1434–1444 The Central Vein Occlusion Study Group N report (1995) A randomized clinical trial of early panretinal photocoagulation for ischemic central vein occlusion. Ophthalmology 102:1434–1444
10.
go back to reference The Central Vein Occlusion Study Group (1993) Baseline and early natural history report: the central vein occlusion study. Arch Ophthalmol 111:1087–1095 The Central Vein Occlusion Study Group (1993) Baseline and early natural history report: the central vein occlusion study. Arch Ophthalmol 111:1087–1095
11.
go back to reference Jonas JB, Kreissig I, Degenring RF (2002) Intravitreal triamcinolone acetonide as treatment of macular edema in central retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 240(9):782–783CrossRefPubMed Jonas JB, Kreissig I, Degenring RF (2002) Intravitreal triamcinolone acetonide as treatment of macular edema in central retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 240(9):782–783CrossRefPubMed
12.
go back to reference The Central Vein Occlusion Study Group M Report (1995) Evaluation of grid pattern photocoagulation for macular edema in central vein occlusion. Ophthalmology 102:1425–1433 The Central Vein Occlusion Study Group M Report (1995) Evaluation of grid pattern photocoagulation for macular edema in central vein occlusion. Ophthalmology 102:1425–1433
13.
go back to reference Laatikainen L, Kohner EM, Khoury D, Blach RK (1977) Panretinal photocoagulation in central retinal vein occlusion: a randomized controlled clinical study. Br J Ophthalmol 61:741–753CrossRefPubMed Laatikainen L, Kohner EM, Khoury D, Blach RK (1977) Panretinal photocoagulation in central retinal vein occlusion: a randomized controlled clinical study. Br J Ophthalmol 61:741–753CrossRefPubMed
14.
go back to reference Glacet-Bernard A, Zourdani A, Milhoub M, Maraqua N, Coscas G, Soubrane G (2001) Effect of isovolemic hemodilution in central retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 239:909–914CrossRefPubMed Glacet-Bernard A, Zourdani A, Milhoub M, Maraqua N, Coscas G, Soubrane G (2001) Effect of isovolemic hemodilution in central retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 239:909–914CrossRefPubMed
15.
go back to reference Hansen LL, Wiek J, Wiederholt M (1989) A randomised prospective study of treatment of non-ischaemic central retinal vein occlusion by isovolaemic haemodilution. Br J Ophthalmol 73:895–899CrossRefPubMed Hansen LL, Wiek J, Wiederholt M (1989) A randomised prospective study of treatment of non-ischaemic central retinal vein occlusion by isovolaemic haemodilution. Br J Ophthalmol 73:895–899CrossRefPubMed
16.
go back to reference Wolf S, Arend O, Bertram B, Remky A, Schulte K, Wald KJ, Reim M (1994) Hemodilution therapy in central retinal vein occlusion. One-year results of a prospective randomized study. Graefes Arch Clin Exp Ophthalmol 232(1):33–39CrossRefPubMed Wolf S, Arend O, Bertram B, Remky A, Schulte K, Wald KJ, Reim M (1994) Hemodilution therapy in central retinal vein occlusion. One-year results of a prospective randomized study. Graefes Arch Clin Exp Ophthalmol 232(1):33–39CrossRefPubMed
17.
go back to reference Opremcak EM, Rehmar AJ, Ridenour CD, Kurz DE, Borkowski LM (2006) Radial optic neurotomy with adjunctive intraocular triamcinolone for central retinal vein occlusion: 63 consecutive cases. Retina 26:306–313CrossRefPubMed Opremcak EM, Rehmar AJ, Ridenour CD, Kurz DE, Borkowski LM (2006) Radial optic neurotomy with adjunctive intraocular triamcinolone for central retinal vein occlusion: 63 consecutive cases. Retina 26:306–313CrossRefPubMed
18.
go back to reference Garcia-Arumi J, Boixedera A, Martinez-Castillo V, Castillo R, Dou A, Corcostegui B (2003) Chorioretinal anastomosis after radial optic neurotomy for central retinal vein occlusion. Arch Ophthalmol 121:1385–1391CrossRef Garcia-Arumi J, Boixedera A, Martinez-Castillo V, Castillo R, Dou A, Corcostegui B (2003) Chorioretinal anastomosis after radial optic neurotomy for central retinal vein occlusion. Arch Ophthalmol 121:1385–1391CrossRef
19.
go back to reference Greenberg PB, Martidis A, Rogers AH, Duker JS, Reichel E (2002) Intravitreal triamcinolone acetonide for macular oedema due to central retinal vein occlusion. Br J Ophthalmol 86:247–248CrossRefPubMed Greenberg PB, Martidis A, Rogers AH, Duker JS, Reichel E (2002) Intravitreal triamcinolone acetonide for macular oedema due to central retinal vein occlusion. Br J Ophthalmol 86:247–248CrossRefPubMed
20.
go back to reference Park CH, Jaffe GJ, Fekrat S (2003) Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central retinal vein occlusion. Am J Ophthalmol 136:419–425CrossRefPubMed Park CH, Jaffe GJ, Fekrat S (2003) Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central retinal vein occlusion. Am J Ophthalmol 136:419–425CrossRefPubMed
21.
go back to reference Ip MS, Gottlieb JL, Kahana A, Scott IU, Altaweel MM, Blodi BA, Gangnon RE, Puliafito CA (2004) Intravitreal triamcinolone for the treatment of macular edema associated with central retinal vein occlusion. Arch Ophthalmol 122:1131–1136CrossRefPubMed Ip MS, Gottlieb JL, Kahana A, Scott IU, Altaweel MM, Blodi BA, Gangnon RE, Puliafito CA (2004) Intravitreal triamcinolone for the treatment of macular edema associated with central retinal vein occlusion. Arch Ophthalmol 122:1131–1136CrossRefPubMed
22.
go back to reference DeCroos FC, Shuler RK Jr, Stinnett S, Fekrat S (2009) Pars plana vitrectomy, internal limiting membrane peeling, and panretinal endophotocoagulation for macular edema secondary to central retinal vein occlusion. Am J Ophthalmol 147(4):627–633CrossRefPubMed DeCroos FC, Shuler RK Jr, Stinnett S, Fekrat S (2009) Pars plana vitrectomy, internal limiting membrane peeling, and panretinal endophotocoagulation for macular edema secondary to central retinal vein occlusion. Am J Ophthalmol 147(4):627–633CrossRefPubMed
23.
go back to reference Mandelcorn MS, Mandelcorn E, Guan K, Adatia FA (2007) Surgical macular decompression for macular edema in retinal vein occlusion. Can J Ophthalmol 42(1):116–122PubMed Mandelcorn MS, Mandelcorn E, Guan K, Adatia FA (2007) Surgical macular decompression for macular edema in retinal vein occlusion. Can J Ophthalmol 42(1):116–122PubMed
24.
go back to reference Takahashi K, Muraoka K, Kishi S, Shimizu K (1998) Formation of retinochoroidal collaterals in central retinal vein occlusion. Am J Ophthalmol 126:91–99CrossRefPubMed Takahashi K, Muraoka K, Kishi S, Shimizu K (1998) Formation of retinochoroidal collaterals in central retinal vein occlusion. Am J Ophthalmol 126:91–99CrossRefPubMed
Metadata
Title
Venous retinal flow reperfusion mechanisms following radial optic neurotomy with adjunctive intraocular triamcinolone in central retinal vein occlusion
Authors
Pina Fortunato
Liliana Pollazzi
Maurizio Baroni
Attilio Evangelisti
Agostino La Torre
Publication date
01-02-2010
Publisher
Springer-Verlag
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 2/2010
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-009-1187-2

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