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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-10-2015 | Retinal Disorders

Venous oxygen saturation is reduced and variable in central retinal vein occlusion

Authors: Thorunn Scheving Eliasdottir, David Bragason, Sveinn Hakon Hardarson, Gudrun Kristjansdottir, Einar Stefánsson

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 10/2015

Abstract

Purpose

To estimate the presence and variability of retinal hypoxia in patients with central retinal vein occlusion (CRVO).

Method

Hemoglobin oxygen saturation was measured in retinal vessels of both eyes in 14 patients with unilateral CRVO. The noninvasive spectrophotometric retinal oximeter is based on a fundus camera and simultaneously captures two images at 570 nm and 600 nm wavelengths. Five of the patients were followed with repeated retinal oximetry images over time.

Results

The mean oxygen saturation in retinal venules was 31 % ±12 % in CRVO eyes and 52 % ±11 % in unaffected fellow eyes (mean ±SD, n = 14, p < 0.0001). The arteriovenous difference was 63 % ±11 % in eyes with CRVO and 43 % ±7 % in fellow eyes (p < 0.0001). The variability of retinal venous oxygen saturation was substantial within and between eyes affected by CRVO. Venular oxygen saturation improved with treatment and over time in all five patients that were followed.

Conclusion

CRVO eyes are hypoxic compared to fellow eyes and arteriovenous difference in hemoglobin oxygen saturation is increased. This is consistent with tissue hypoxia resulting from reduced blood flow. Further studies are needed to understand the correlation between hypoxia, severity of disease and prognosis.

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Title: Venous oxygen saturation is reduced and variable in central retinal vein occlusion
Authors: Thorunn Scheving Eliasdottir
David Bragason
Sveinn Hakon Hardarson
Gudrun Kristjansdottir
Einar Stefánsson
Publication date: 01-10-2015
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 10/2015
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-014-2849-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Venous oxygen saturation is reduced and variable in central retinal vein occlusion

Abstract

Purpose

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Method

Results

Conclusion

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