Top

Published in:

01-08-2013 | Poster presentation

Vascular smooth muscle cell activation depends on NOS-1-derived NO and consequent peroxynitrite generation

Authors: Karin Scheschowitsch, Regina de Sordi, João Alfredo de Moraes, Christina Barja-Fidalgo, Jamil Assreuy

Published in: Critical Care | Special Issue 4/2013

Excerpt

Low levels of nitric oxide (NO) play a key role in vascular tonus maintenance. Previous results from our laboratory show that hypotension and mortality during sepsis are prevented by the early administration of NOS-1 inhibitors. The aim of this study was thus to investigate the role of NOS-1 and NOS-3-derived NO and of other reactive oxygen species (ROS) in smooth muscle cell activation. …

Title: Vascular smooth muscle cell activation depends on NOS-1-derived NO and consequent peroxynitrite generation
Authors: Karin Scheschowitsch
Regina de Sordi
João Alfredo de Moraes
Christina Barja-Fidalgo
Jamil Assreuy
Publication date: 01-08-2013
Publisher: BioMed Central
Published in: Critical Care / Issue Special Issue 4/2013
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc12981

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Vascular smooth muscle cell activation depends on NOS-1-derived NO and consequent peroxynitrite generation

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Special Issue 4/2013

Study of the effect of C1-esterase inhibitor administration to the sepsis pig model

Rapid molecular test (SeptiFast®) reduced time for adjustment of antibiotic treatment in comparison with conventional blood cultures in critically ill sepsis patients: a randomized controlled clinical trial (preliminary results)

Effect of sepsis challenge in chronic inflammation state on mortality and long-term pathological findings in rats

Hourly and accurate severe sepsis classification using kernel density estimates

Microbiological profile in an ICU in 1 year

Vasopressin secretion in sepsis-surviving animals following dehydration