Top

Published in:

01-06-2012 | Case Report

Varicella zoster virus meningoencephalitis accompanied by rhabdomyolysis without skin eruption

Authors: Go Un Kim, Bon D. Ku

Published in: Neurological Sciences | Issue 3/2012

Abstract

We report a case of a 38-year-old man with a Varicella zoster virus (VZV) reactivation who manifested meningoencephalitis accompanied by rhabdomyolysis without a skin eruption. During the acute phase, VZV DNA was detected in serum and cerebrospinal fluid (CSF) by the polymerase chain reaction (PCR). After 16 days, all symptoms and signs resolved, and follow-up PCR studies revealed negative conversion of VZV in the serum and CSF. We discuss the possible underlying mechanism of VZV reactivation in our patient. This is the first case report of VZV reactivation meningoencephalitis accompanied by rhabdomyolysis without skin eruption demonstrated by viral DNA in the serum and CSF.

Pirounaki M, Liatsos G, Elefsiniotis I, Skounakis M, Moulakakis A (2007) Unusual onset of Varicella zoster reactivation with meningoencephalitis, followed by rhabdomyolysis and renal failure in a young immunocompetent patient. Scand J Infect Dis 39:90–93PubMedCrossRef

Gilden DH, Kleinschmidt-DeMasters BK, LaGuardia JJ, Mahalingam R, Cohrs RJ (2000) Neurologic complications of the reactivation of Varicella-zoster virus. N Engl J Med 342:635–645PubMedCrossRef

Khan FY (2009) Rhabdomyolysis: a review of the literature. Neth J Med 67:272–283PubMed

Hollenstein U, Thalhammer F, Burgmann H (1998) Disseminated intravascular coagulation (DIC) and rhabdomyolysis in fulminant Varicella infection—case report and review of the literature. Infection 26:306–308PubMedCrossRef

Will MJ, Hecker RB, Wathen PI (1996) Primary Varicella-zoster-induced rhabdomyolysis. South Med J 89:915–920PubMedCrossRef

Rodríguez Ferrán L, Vernet Bori A, Poo Argüelles P, Fernández Alvarez E, García Calatayud J (2001) Varicella induced rhabdomyolysis. An Esp Pediatr 55:374–377PubMed

Beby-Defaux A, Brabant S, Chatellier D, Bourgoin A, Robert R, Ruckes T, Agius G (2009) Disseminated Varicella with multiorgan failure in an immunocompetent adult. J Med Virol 81:747–749PubMedCrossRef

de Jong MD, Weel JF, van Oers MH, Boom R, Wertheim-van Dillen PM (2001) Molecular diagnosis of visceral herpes zoster. Lancet 30(357):2101–2102CrossRef

Jantsch J, Schmidt B, Bardutzky J, Bogdan C, Eckardt KU, Raff U (2011) Lethal Varicella-zoster virus reactivation without skin lesions following renal transplantation. Nephrol Dial Transplant 26:365–368PubMedCrossRef

10.

Ishizawa J, Fujita H, Iguchi M, Tachibana T, Taguchi J, Ishigatsubo Y (2007) Quantification of circulating Varicella-zoster virus DNA for follow-up in a case of visceral Varicella-zoster infection ameliorated with intravenous acyclovir. Int J Hematol 85:242–245PubMedCrossRef

Title: Varicella zoster virus meningoencephalitis accompanied by rhabdomyolysis without skin eruption
Authors: Go Un Kim
Bon D. Ku
Publication date: 01-06-2012
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 3/2012
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-011-0777-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Varicella zoster virus meningoencephalitis accompanied by rhabdomyolysis without skin eruption

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2012

The roles of P2X7 receptor in regional-specific microglial responses in the rat brain following status epilepticus

The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticus

Cerebral venous and sinus thrombosis associated with subcutaneous immunoglobulin injection and oral contraceptive use

Retraction Note: The sequential magnetic resonance images of tri-methyl tin leukoencephalopathy

Trigeminal neuralgia as unusual isolated symptom of fungal paranasal sinusitis in patients with haematological malignancies

Isolated polio-like syndrome after tick-borne encephalitis presenting with acute hyperckemia