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International Archives of Occupational and Environmental Health

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01-01-2009 | Original Article

Variations in arsenic methylation capacity and oxidative DNA lesions over a 2-year period in a high arsenic-exposed population

Authors: Yuan-yuan Xu, Yi Wang, Xin Li, Miao He, Peng Xue, Jing-qi Fu, Hui-hui Wang, Gui-fan Sun

Published in: International Archives of Occupational and Environmental Health | Issue 2/2009

Abstract

Objective

To assess long-term variations in arsenic methylation and oxidative DNA lesions of chronic high arsenic-exposed populations.

Methods

A follow-up study was conducted in 64 chronic high arsenic-exposed subjects from 2004 to 2006. Urinary arsenic species and 8-hydroxydeoxyguanine were measured.

Results

Percentages of urinary inorganic arsenic, monomethylarsonate and urinary 8-hydroxydeoxyguanine (8-OHdG) level were significantly higher, but the percentage of dimethylarsinate, the primary methylation index (PMI) and secondary methylation index (SMI) was lower in the ninth year of arsenic exposure compared with the seventh year. Substantial differences in relative arsenic methylation capacity were observed between the seventh and ninth year. Percentages of arsenic species, PMI and SMI were significantly correlated between siblings, and between parents and children.

Conclusions

Arsenic methylation may decrease, but oxidative DNA lesions may increase with the increase of cumulative arsenic exposure level. Both genetic and environmental factors may contribute to variability in arsenic methylation.

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Title: Variations in arsenic methylation capacity and oxidative DNA lesions over a 2-year period in a high arsenic-exposed population
Authors: Yuan-yuan Xu
Yi Wang
Xin Li
Miao He
Peng Xue
Jing-qi Fu
Hui-hui Wang
Gui-fan Sun
Publication date: 01-01-2009
Publisher: Springer-Verlag
Published in: International Archives of Occupational and Environmental Health / Issue 2/2009
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-008-0329-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Variations in arsenic methylation capacity and oxidative DNA lesions over a 2-year period in a high arsenic-exposed population

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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