Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 2/2017

01-02-2017 | Head and Neck

Variation in treatment and outcome in the early stage oral cavity squamous cell carcinoma

Authors: Darragh S. Gogarty, Paul Lennon, Sandra Deady, J. Barry O’Sullivan, Orla McArdle, Mary Leader, Patrick Sheahan, James Paul O’Neill

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2017

Login to get access

Abstract

This study aims to determine the survival impact of patient characteristics and treatment options associated with the early stage oral cavity squamous cell carcinoma, OCSCC. The methods are analysis of Irish cancer database examining T1/2, N0, and M0 cases of OCSCC from 1997 to 2007 inclusive. In total, 397 cases were identified. Anterolateral tongue accounted for 52.9 % of cases. Increased age at diagnosis and smoking are independent prognostic survival indicators associated with poorer outcomes. Surgery as the initial intervention was associated with significantly better survival outcomes, while surgery and adjuvant radiotherapy significantly worse outcomes. Surgical intervention is recommended as the first-line treatment in the early stage OCSCC in combination with elective neck dissection.
Literature
1.
Barnes L, Eveson JW, Reichart P, Sidransky D (2005) Pathology and genetics of head and neck tumours. IARC Press, Lyon
2.
Franceschi S, Bidoli E, Herrero R, Munoz N (2000) Comparison of cancers of the oral cavity and pharynx worldwide: etiological clues. Oral Oncol 36:106–115CrossRefPubMed
3.
Gogarty DS, Shuman A, O’Sullivan EM et al (2016) Conceiving a national head and neck cancer screening programme. J Laryngol Otol 130:8–14CrossRefPubMed
4.
Funk GF, Karnell LH, Robinson RA, Zhen WK, Trask DK, Hoffman HT (2002) Presentation, treatment, and outcome of oral cavity cancer: a national cancer data base report. Head Neck 24:165–180CrossRefPubMed
5.
Shiboski CH, Shiboski SC, Silverman S Jr (2000) Trends in oral cancer rates in the United States, 1973–1996. Comm Dent Oral Epidemiol 28:249–256CrossRef
6.
Sowder JC, Cannon RB, Buchmann LO et al (2015) Determinants of Survival in Early Stage (T1-2N0M0) Oral Cavity Cancer: A population based study. In: Meeting AHaNSA, ed. American Head and Neck Society Annual Meeting. Am Head Neck Soc Ann Meet Am Head Neck Soc
7.
Luryi AL, Chen MM, Mehra S, Roman SA, Sosa JA, Judson BL (2015) Treatment Factors Associated With Survival in Early-Stage Oral Cavity Cancer: Analysis of 6830 Cases From the National Cancer Data Base. JAMA otolaryngology– head & neck surgery 141:593–598CrossRef
8.
Pfister DG, Spencer S, Brizel DM et al (2014) Head and neck cancers, Version 2.2014. Clinical practice guidelines in oncology. J Nat Comprehen Cancer Network JNCCN 12:1454–1487
9.
10.
11.
Rogers SN, Brown JS, Woolgar JA et al (2009) Survival following primary surgery for oral cancer. Oral Oncol 45:201–211CrossRefPubMed
12.
Dansky Ullmann C, Harlan LC, Shavers VL, Stevens JL (2012) A population-based study of therapy and survival for patients with head and neck cancer treated in the community. Cancer 118:4452–4461
13.
Head and Neck Cancer. Mutlimodality Management: Springer, 2011
14.
Yuen APW, Lam KY, Chan ACL et al (1999) Clinicopathological analysis of elective neck dissection for N0 neck of early oral tongue carcinoma1. Am J Surg 177:90–92CrossRefPubMed
15.
Kowalski LP, Sanabria A (2007) Elective neck dissection in oral carcinoma: a critical review of the evidence. Acta Otorhinolaryngol Ital 27:113–117PubMedPubMedCentral
16.
Liao CT, Lin CY, Fan KH et al (2012) Identification of a high-risk group among patients with oral cavity squamous cell carcinoma and pT1-2N0 disease. Int J Radiat Oncol Biol Phys 82:284–290CrossRefPubMed
17.
O’Brien K, Comber H, Sharp L (2014) Completeness of case ascertainment at the Irish National Cancer Registry. Ir J Med Sci 183:219–224CrossRefPubMed
18.
Tyczynski JE DE (2003) Parkin DM Standards and guidelines for cancer registration in Europe. International Agency for Research on Cancer
19.
20.
AJCC Cancer Staging Manual (1997) American Joint Committee on Cancer, 5th edn. Lippincott-Raven
21.
Department of Health and General Practice Small Area Health Research Unit. A national deprivation index for health and health services research. Trinity College, Dublin (2013)
22.
Camilon PR, Stokes WA, Fuller CW, Nguyen SA, Lentsch EJ (2014) Does buccal cancer have worse prognosis than other oral cavity cancers? Laryngoscope 124:1386–1391CrossRefPubMed
23.
Rusthoven K, Ballonoff A, Raben D, Chen C (2008) Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma. Cancer 112:345–351CrossRefPubMed
24.
Bell RB, Kademani D, Homer L, Dierks EJ, Potter BE (2007) Tongue cancer: Is there a difference in survival compared with other subsites in the oral cavity? J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 65:229–236CrossRef
25.
Lubek JE, Dyalram D, Perera EH, Liu X, Ord RA (2013) A retrospective analysis of squamous carcinoma of the buccal mucosa: an aggressive subsite within the oral cavity. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 71:1126–1131CrossRef
26.
Rusthoven KE, Raben D, Song JI, Kane M, Altoos TA, Chen C (2010) Survival and patterns of relapse in patients with oral tongue cancer. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 68:584–589CrossRef
27.
Shah JP, Patel SG, Singh B (2012) Jatin Shah’s head and neck surgery and oncology, 4th edn. Elsevier, Philadelphia
28.
Kademani D, Bell RB, Bagheri S et al (2005) Prognostic factors in intraoral squamous cell carcinoma: the influence of histologic grade. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 63:1599–1605CrossRef
29.
Spiro RH, Huvos AG, Wong GY, Spiro JD, Gnecco CA, Strong EW (1986) Predictive value of tumor thickness in squamous carcinoma confined to the tongue and floor of the mouth. Am J Surg 152:345–350CrossRefPubMed
30.
Leemans CR, Tiwari R, Nauta JJ, van der Waal I, Snow GB (1994) Recurrence at the primary site in head and neck cancer and the significance of neck lymph node metastases as a prognostic factor. Cancer 73:187–190CrossRefPubMed
31.
Grandi C, Allossio M, Moglia D (1985) Prognostic significance of lymphatic spread in head and neck carcinomas: therapeutic implications. Head Neck Surg 8:67CrossRefPubMed
32.
Shah JP (1990) Cervical lymph node metastases–diagnostic, therapeutic, and prognostic implications. Oncology (Williston Park, NY) 4:61–69 (discussion 72, 6)
33.
Shah JP, Cendon RA, Farr HW, Strong EW (1976) Carcinoma of the oral cavity. factors affecting treatment failure at the primary site and neck. Am J Surg 132:504–507CrossRefPubMed
34.
35.
VanderWalde NA, Meyer AM, Liu H et al (2013) Patterns of care in older patients with squamous cell carcinoma of the head and neck: a surveillance, epidemiology, and end results-medicare analysis. J Geriat Oncol 4:262–270CrossRef
36.
Bellis MA, Hughes K, Nicholls J, Sheron N, Gilmore I, Jones L (2016) The alcohol harm paradox: using a national survey to explore how alcohol may disproportionately impact health in deprived individuals. BMC Public Health 16:1–10CrossRef
37.
38.
Barry CP, Ahmed F, Rogers SN et al (2015) Influence of surgical margins on local recurrence in T1/T2 oral squamous cell carcinoma. Head Neck 37:1176–1180CrossRefPubMed
39.
Bekiroglu F, Ghazali N, Laycock R, Katre C, Lowe D, Rogers SN (2011) Adjuvant radiotherapy and health-related quality of life of patients at intermediate risk of recurrence following primary surgery for oral squamous cell carcinoma. Oral Oncol 47:967–973CrossRefPubMed
40.
Sargeran K, Murtomaa H, Safavi SM, Vehkalahti MM, Teronen O (2008) Survival after diagnosis of cancer of the oral cavity. Br J Oral Maxillofac Surg 46:187–191CrossRefPubMed
41.
Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Villaret DB (2005) Retromolar trigone squamous cell carcinoma treated with radiotherapy alone or combined with surgery. Cancer 103:2320–2325CrossRefPubMed
42.
Hitchcock KE, Amdur RJ, Morris CG, Werning JW, Dziegielewski PT, Mendenhall WM (2015) Retromolar trigone squamous cell carcinoma treated with radiotherapy alone or combined with surgery: a 10-year update. Am J Otolaryngol 36:140–145CrossRefPubMed
43.
Zhang H, Dziegielewski PT, Biron VL et al (2013) Survival outcomes of patients with advanced oral cavity squamous cell carcinoma treated with multimodal therapy: a multi-institutional analysis. J Otolaryngol Head Neck Surg (Le Journal d’oto-rhino-laryngologie et de chirurgie cervico-faciale) 42:30
44.
De Zinis LO, Ghizzardi D, Casati E, Nicolai P, Antonelli AR (2002) Salvage surgery in squamous cell carcinoma of the oral cavity]. Acta otorhinolaryngologica Italica: organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 22:135–141
45.
Brown JS, Shaw RJ, Bekiroglu F, Rogers SN (2012) Systematic review of the current evidence in the use of postoperative radiotherapy for oral squamous cell carcinoma. Br J Oral Maxillofac Surg 50:481–489CrossRefPubMed
46.
Fujisawa R, Shibuya H, Harata N, Yuasa-Nakagawa K, Toda K, Hayashi K (2014) Chronological shifts and changing causes of death after radiotherapy for early-stage oral cancer. Int J Clin Oncol 19:24–29CrossRefPubMed
47.
48.
Kelner N, Vartanian JG, Pinto CA, Coutinho-Camillo CM, Kowalski LP (2014) Does elective neck dissection in T1/T2 carcinoma of the oral tongue and floor of the mouth influence recurrence and survival rates? Br J Oral Maxillofac Surg 52:590–597CrossRefPubMed
49.
D’Cruz AK, Vaish R, Kapre N et al (2015) Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med 373(6):521–529CrossRefPubMed
50.
Feng Z, Li JN, Li CZ, Guo CB (2014) Elective neck dissection versus observation in the management of early tongue carcinoma with clinically node-negative neck: a retrospective study of 229 cases. Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery 42:806–810CrossRef
51.
Fasunla AJ, Greene BH, Timmesfeld N, Wiegand S, Werner JA, Sesterhenn AM (2011) A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck. Oral Oncol 47:320–324CrossRefPubMed
52.
Flach GB, Tenhagen M, de Bree R et al (2013) Outcome of patients with early stage oral cancer managed by an observation strategy towards the N0 neck using ultrasound guided fine needle aspiration cytology: No survival difference as compared to elective neck dissection. Oral Oncol 49:157–164CrossRefPubMed
Metadata
Title
Variation in treatment and outcome in the early stage oral cavity squamous cell carcinoma
Authors
Darragh S. Gogarty
Paul Lennon
Sandra Deady
J. Barry O’Sullivan
Orla McArdle
Mary Leader
Patrick Sheahan
James Paul O’Neill
Publication date
01-02-2017
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 2/2017
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-016-4267-z

Other articles of this Issue 2/2017

European Archives of Oto-Rhino-Laryngology 2/2017 Go to the issue

Review Article

Hyoid bone displacement as parameter for swallowing impairment in patients treated for advanced head and neck cancer

Head and Neck

The adverse impact of surveillance intervals on the sensitivity of FDG-PET/CT for the detection of distant metastases in head and neck cancer patients

Case Report

Cochlear implantation in deaf patients with eosinophilic otitis media using subtotal petrosectomy and mastoid obliteration

Case Report

Congenital cholesteatoma together with ossicular chain anomaly

Rhinology

Osmophobia and olfactory functions in patients with migraine

Rhinology

A new surgical technique versus an old marker: can expansion sphincter pharyngoplasty reduce C-reactive protein levels in patients with obstructive sleep apnea?