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European Spine Journal

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24-08-2023 | Vancomycin | Original Article

Surgical site infection prophylaxis with intra-wound vancomycin powder for uninstrumented spine surgeries: a meta-analysis

Authors: Connor Zale, Marc Nicholes, Serena Hu, JMatthew Cage

Published in: European Spine Journal | Issue 12/2023

Abstract

Purpose

It is unclear if intra-wound vancomycin powder significantly reduces the infection rate for uninstrumented spine surgery. The purpose of this study is to compare the rate of surgical site infection (SSI) in uninstrumented spine surgery that used vancomycin powder against controls.

Methods

A search was performed on PUBMED/MEDLINE, Cochrane Database and Embase on 14 October 2022. Search keywords were “vancomycin, spine surgery, uninstrumented and spinal surgery.” Instrumented cases were excluded. Type of surgery, type of treatment and incidence of infection among experimental or control were recorded.

Results

288 articles were obtained from a literature search. 16 studies met inclusion criteria. 6/16 studies that reported on the infection rate using vancomycin were obtained.

There were 1376 control cases with 20 cases of post-operative infection (1.45% overall). There were 795 cases that received prophylactic intra-wound vancomycin powder with 10 cases of infection reported (1.26%). There was no significant difference in infections between cases that received vancomycin compared to control. On subgroup analysis, studies that had a high rate of infection (Strom and Cannon) had a significant difference on the rate of infection with the use of vancomycin compared to control.

Discussion and conclusion

The current study was unable to conclude that vancomycin decreased the rate of surgical site infections. Vancomycin use may be useful in populations that have a high rate of infection. Limitations in this study include the small number of studies that report on the use of vancomycin on uninstrumented spine surgery.

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Title: Surgical site infection prophylaxis with intra-wound vancomycin powder for uninstrumented spine surgeries: a meta-analysis
Authors: Connor Zale
Marc Nicholes
Serena Hu
JMatthew Cage
Publication date: 24-08-2023
Publisher: Springer Berlin Heidelberg
Keywords: Vancomycin
Spinal Surgery
Published in: European Spine Journal / Issue 12/2023
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-023-07897-w

2024 ASCO Annual Meeting

Springer Medicine

Surgical site infection prophylaxis with intra-wound vancomycin powder for uninstrumented spine surgeries: a meta-analysis

Abstract

Purpose

Methods

Results

Discussion and conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Discussion and conclusion

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