Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
International Ophthalmology
Published in: International Ophthalmology 3/2019

01-03-2019 | Original Paper

Validation of the structure–function correlation report from the heidelberg edge perimeter and spectral-domain optical coherence tomography

Authors: Qi N. Cui, Scott J. Fudemberg, Arthur F. Resende, Thuy-Anh Vu, Chen Zhou, Kamran Rahmatnejad, Lisa A. Hark, Jonathan S. Myers, L. Jay Katz, Michael Waisbourd

Published in: International Ophthalmology | Issue 3/2019

Login to get access

Abstract

Purpose

To compare the diagnostic assessment of glaucoma specialists with an automated structure–function correlation report combining visual field (VF) and spectral-domain optical coherence tomography (SD-OCT) imagining in subjects with glaucoma.

Methods

This prospective, cross-sectional study was conducted at Wills Eye Hospital, Philadelphia, PA, USA. Subjects with glaucoma received ophthalmic examination, VF testing, and SD-OCT imaging. An automated report was generated describing structure–function correlations between the two structural elements [retinal nerve fiber layer (RNFL) and Bruch’s membrane opening-minimum rim width (MRW)] and VF sectors. Three glaucoma specialists masked to the automated report and to each other identified clinically significant structure–function correlations between the VF and SD-OCT reports. Raw agreement and chance-corrected agreement (kappa statistics) between the automated report and the clinical assessments were compared.

Results

A total of 53 eyes from 45 subjects with glaucoma were included in this study. The overall agreement between the automated report and clinical assessment comparing MRW and VF was good at 74.8% with a kappa of 0.62 (95% CI 0.55–0.69). Agreements for the six different MRW sections were moderate to good with kappa values ranging from 0.54 to 0.69. For mean RNFL thickness and VF comparisons, agreement between the automated report and clinical assessment was 75.4% with a kappa of 0.62 (95% CI 0.54–0.70). For different RNFL sectors, kappa values ranged from 0.47 (moderate agreement) to 0.80 (good agreement).

Conclusions

This study suggests that the automated structure–function report combining results from the SD-OCT and the HEP may assist in the evaluation and management of glaucoma.
Literature
1.
Medeiros FA, Lisboa R, Weinreb RN et al (2012) A combined index of structure and function for staging glaucomatous damage. Arch Ophthalmol 130(9):1107–1116CrossRefPubMedPubMedCentral
2.
Tatham AJ, Weinreb RN, Zangwill LM et al (2013) Estimated retinal ganglion cell counts in glaucomatous eyes with localized retinal nerve fiber layer defects. Am J Ophthalmol 156(3):578–587 e571CrossRefPubMedPubMedCentral
3.
Lopez-Pena MJ, Ferreras A, Larrosa JM et al (2011) Relationship between standard automated perimetry and retinal nerve fiber layer parameters obtained with optical coherence tomography. J Glaucoma 20(7):422–432CrossRefPubMed
4.
Bowd C, Zangwill LM, Medeiros FA et al (2006) Structure–function relationships using confocal scanning laser ophthalmoscopy, optical coherence tomography, and scanning laser polarimetry. Invest Ophthalmol Vis Sci 47(7):2889–2895CrossRefPubMed
5.
Leite MT, Zangwill LM, Weinreb RN et al (2012) Structure–function relationships using the Cirrus spectral domain optical coherence tomograph and standard automated perimetry. J Glaucoma 21(1):49–54CrossRefPubMedPubMedCentral
6.
Rao HL, Zangwill LM, Weinreb RN et al (2011) Structure–function relationship in glaucoma using spectral-domain optical coherence tomography. Arch Ophthalmol 129(7):864–871CrossRefPubMed
7.
Chauhan BC, Burgoyne CF (2013) From clinical examination of the optic disc to clinical assessment of the optic nerve head: a paradigm change. Am J Ophthalmol 156(2):218–227 e212CrossRefPubMedPubMedCentral
8.
Belghith A, Bowd C, Medeiros FA et al (2016) Does the location of Bruch’s membrane opening change over time? Longitudinal analysis using San Diego automated layer segmentation algorithm (SALSA). Invest Ophthalmol Vis Sci 57(2):675–682CrossRefPubMedPubMedCentral
9.
Reis AS, O’Leary N, Yang H et al (2012) Influence of clinically invisible, but optical coherence tomography detected, optic disc margin anatomy on neuroretinal rim evaluation. Invest Ophthalmol Vis Sci 53(4):1852–1860CrossRefPubMedPubMedCentral
10.
Danthurebandara VM, Sharpe GP, Hutchison DM et al (2015) Enhanced structure–function relationship in glaucoma with an anatomically and geometrically accurate neuroretinal rim measurement. Invest Ophthalmol Vis Sci 56(1):98–105CrossRef
11.
Chauhan BC, O’Leary N, Almobarak FA et al (2013) Enhanced detection of open-angle glaucoma with an anatomically accurate optical coherence tomography-derived neuroretinal rim parameter. Ophthalmology 120(3):535–543CrossRefPubMed
12.
Pollet-Villard F, Chiquet C, Romanet JP et al (2014) Structure–function relationships with spectral-domain optical coherence tomography retinal nerve fiber layer and optic nerve head measurements. Invest Ophthalmol Vis Sci 55(5):2953–2962CrossRefPubMed
13.
Malik R, Belliveau AC, Sharpe GP et al (2016) Diagnostic accuracy of optical coherence tomography and scanning laser tomography for identifying glaucoma in myopic eyes. Ophthalmology 123:1181–1189CrossRefPubMed
14.
Garway-Heath DF, Poinoosawmy D, Fitzke FW et al (2000) Mapping the visual field to the optic disc in normal tension glaucoma eyes. Ophthalmology 107(10):1809–1815CrossRefPubMed
15.
Strouthidis NG, Vinciotti V, Tucker AJ et al (2006) Structure and function in glaucoma: the relationship between a functional visual field map and an anatomic retinal map. Investig Ophthalmol Vis Sci 47(12):5356–5362CrossRef
16.
Ballae Ganeshrao S, Turpin A, Denniss J et al (2015) Enhancing structure–function correlations in glaucoma with customized spatial mapping. Ophthalmology 122(8):1695–1705CrossRefPubMed
17.
Altman D (1991) Practical statistics for medical research. Chapman and Hall, London
18.
Katz J (1988) Two eyes of one? The data analyst’s dilemma. Ophthalmic Surg 19(8):585–589PubMed
19.
Kanamori A, Naka M, Nagai-Kusuhara A et al (2008) Regional relationship between retinal nerve fiber layer thickness and corresponding visual field sensitivity in glaucomatous eyes. Arch Ophthalmol 126(11):1500–1506CrossRefPubMed
20.
Wu H, de Boer JF, Chen TC (2012) Diagnostic capability of spectral-domain optical coherence tomography for glaucoma. Am J Ophthalmol 153(5):815–826 e812CrossRefPubMedPubMedCentral
21.
Sehi M, Zhang X, Greenfield DS et al (2013) Retinal nerve fiber layer atrophy is associated with visual field loss over time in glaucoma suspect and glaucomatous eyes. Am J Ophthalmol 155(1):73–82 e71CrossRefPubMed
22.
He L, Yang H, Gardiner SK et al (2014) Longitudinal detection of optic nerve head changes by spectral domain optical coherence tomography in early experimental glaucoma. Investig Ophthalmol Vis Sci 55(1):574–586CrossRef
Metadata
Title
Validation of the structure–function correlation report from the heidelberg edge perimeter and spectral-domain optical coherence tomography
Authors
Qi N. Cui
Scott J. Fudemberg
Arthur F. Resende
Thuy-Anh Vu
Chen Zhou
Kamran Rahmatnejad
Lisa A. Hark
Jonathan S. Myers
L. Jay Katz
Michael Waisbourd
Publication date
01-03-2019
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 3/2019
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-018-0836-z

Other articles of this Issue 3/2019

International Ophthalmology 3/2019 Go to the issue

Original Paper

Retrobulbar and intraocular blood flow in anterior ischaemic optic neuropathy are linked to the functional impairment

Case Report

Corneal perforation after noncontact tonometry in patients with active recurrent herpes simplex keratitis: case report

Original Paper

Retinal single-layer analysis with optical coherence tomography shows inner retinal layer thinning in Huntington’s disease as a potential biomarker

Case Report

Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology

Original Paper

Association of polymorphisms of complement factor I rs141853578 (G119R) with age-related macular degeneration in Iranian population

Original Paper

Clinical experience with urgent tube shunt implantation through the ciliary sulcus in phakic eyes