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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 12/2015

01-11-2015 | Colorectal Cancer

Validation of the Memorial Sloan-Kettering Cancer Center Nomogram to Predict Overall Survival After Curative Colectomy in a Chinese Colon Cancer Population

Authors: Maoxing Liu, MD, Hong Qu, PhD, Zhaode Bu, MD, Donglai Chen, BS, Beihai Jiang, PhD, Ming Cui, MD, Jiadi Xing, MD, Hong Yang, MD, Zaozao Wang, PhD, Jiabo Di, PhD, Lei Chen, MD, Chenghai Zhang, MD, Zhendan Yao, MD, Nan Zhang, MD, Fei Tan, MD, Jin Gu, MD, Ziyu Li, MD, Xiangqian Su, MD

Published in: Annals of Surgical Oncology | Issue 12/2015

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Abstract

Background

Colon cancer nomogram designed by Memorial Sloan-Kettering Cancer Center (MSKCC) is an online prediction tool to predict overall survival for individual patient after curative resection. However, this model was never externally validated. We evaluated the accuracy of this nomogram in an independent external Chinese cohort.

Methods

Clinical data from 1005 patients who underwent primary curative-intent surgery at Peking University Cancer Hospital & Institute between 1996 and 2008 were used for external validation. Clinicopathologic characteristics and the performance of the MSKCC nomogram for prediction of overall survival were evaluated for 985 patients with complete data by using concordance index (C-index) and calibration plot.

Results

The C-index for the MSKCC nomogram was 0.71 in the Chinese cohort, compared with 0.67 for American Joint Committee on Cancer (AJCC) stage (P < .0001). This suggests that the nomogram discriminates overall survival better than AJCC staging system. Calibration plot showed a good calibration of the nomogram in the validation cohort. Furthermore, the MSKCC nomogram prediction illustrated the heterogeneity for survival of Chinese patients within each AJCC stage.

Conclusions

The MSKCC nomogram for colon cancer provides more accurate survival predictions than the AJCC staging system when applied to an external Chinese cohort. The MSKCC nomogram improved individualized prediction of survival and may aid in more accurate patient counseling, selection of various treatment options, and follow-up scheduling.
Appendix
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Metadata
Title
Validation of the Memorial Sloan-Kettering Cancer Center Nomogram to Predict Overall Survival After Curative Colectomy in a Chinese Colon Cancer Population
Authors
Maoxing Liu, MD
Hong Qu, PhD
Zhaode Bu, MD
Donglai Chen, BS
Beihai Jiang, PhD
Ming Cui, MD
Jiadi Xing, MD
Hong Yang, MD
Zaozao Wang, PhD
Jiabo Di, PhD
Lei Chen, MD
Chenghai Zhang, MD
Zhendan Yao, MD
Nan Zhang, MD
Fei Tan, MD
Jin Gu, MD
Ziyu Li, MD
Xiangqian Su, MD
Publication date
01-11-2015
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue 12/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-015-4495-2

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