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Journal of Interventional Cardiac Electrophysiology

Published in:

01-10-2009

Validating optimal function of the closed loop stimulation sensor with high right septal ventricular electrode placement in ‘ablate and pace’ patients

Authors: John Silberbauer, Paul S. G. Hong, Rick A. Veasey, Nadeem A. Maddekar, Wasing Taggu, Nikhil R. Patel, Guy W. Lloyd, Neil Sulke

Published in: Journal of Interventional Cardiac Electrophysiology | Issue 1/2009

Abstract

Purpose

The study aim was to validate the closed loop stimulation (CLS) vs. accelerometer (ACC) rate-responsive sensors with electrodes placed in the right ventricular high septal (RVHS) or right ventricular apical (RVA) lead positions in patients following ‘ablate and pace’ therapy for persistent atrial fibrillation.

Methods

‘Ablate and pace’ patients were randomised to either RVHS or RVA electrode placement with a dual sensor device. A double-blind crossover study comparing CLS vs. ACC rate-response pacing modes was undertaken. Subjects undertook cardiopulmonary testing with constant workload light exercise followed by a ramp protocol in addition to activity of daily living assessments.

Results

Twenty subjects (14 male; age, 74 ± 8 years) were studied. Heart rate increase was greater from lying to sitting with ACC. With mental stress, heart rate increase was greater with CLS. Peak heart rates were similar for stair ascent and descent in ACC mode. With CLS mode, however, the peak heart rate was significantly lower for stair descent. There was no difference between modes in mean response time, oxygen deficit, peak VO₂, VO₂ at anaerobic threshold, peak heart rate, total exercise time and total workload. CLS function was equally optimal at both electrode sites.

Conclusions

CLS rate adaptive pacing is appropriate for ‘ablate and pace’ patients, and this sensor functions equally well using RVA or RVHS lead positions.

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Title: Validating optimal function of the closed loop stimulation sensor with high right septal ventricular electrode placement in ‘ablate and pace’ patients
Authors: John Silberbauer
Paul S. G. Hong
Rick A. Veasey
Nadeem A. Maddekar
Wasing Taggu
Nikhil R. Patel
Guy W. Lloyd
Neil Sulke
Publication date: 01-10-2009
Publisher: Springer US
Published in: Journal of Interventional Cardiac Electrophysiology / Issue 1/2009
Print ISSN: 1383-875X
Electronic ISSN: 1572-8595
DOI: https://doi.org/10.1007/s10840-009-9426-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Validating optimal function of the closed loop stimulation sensor with high right septal ventricular electrode placement in ‘ablate and pace’ patients

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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