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International Urogynecology Journal

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22-05-2023 | Vaginal Cancer | Original Article

Colpocleisis: reoperation risk and risk of uterine and vaginal cancer: A nationwide cohort study

Authors: Marie Hammerbak-Andersen, Niels Klarskov, Karen R. Husby

Published in: International Urogynecology Journal | Issue 10/2023

Abstract

Introduction and hypothesis

We aimed to evaluate the risk of reoperation and uterine (myometrial, endometrial, and cervical) and vaginal cancer after colpocleisis performed during the years 1977–2018. Furthermore, we also aimed to assess the development in colpocleisis procedures performed during the study period.

Methods

Danish nationwide registers covering operations, diagnoses, and life events can be linked on an individual level owing to the unique personal numbers of all Danish residents. We performed a nationwide historical cohort study including women born before year 2000 who underwent colpocleisis between 1977 and 2018 (N = 2,228) using the Danish National Patient Registry (DNPR). We followed the cohort until death/emigration/31 December 2018, whichever came first. Primary outcomes were number of pelvic organ prolapse (POP) operations performed after colpocleisis and uterine and vaginal cancer diagnosed after colpocleisis in a subgroup of women with the uterus in situ. This was assessed with cumulative incidences.

Results

During follow-up (median 5.6 years) 6.5% and 8.2% underwent POP surgery within 2 and 10 years after colpocleisis respectively. Within 10 years after colpocleisis 0.5% (N = 8) were diagnosed with uterine or vaginal cancer in the subgroup of women with their uterus (N = 1,970). During the study time 37–80 women underwent colpocleisis yearly and the mean age increased (77.1 to 81.4 years).

Conclusion

Despite smaller studies showing no recurrence after colpocleisis, we found that 6.5% underwent reoperation within 2 years. Few women were diagnosed with uterine or vaginal cancer after colpocleisis. The increased age at the time of colpocleisis indicates changed attitudes regarding surgical treatment for elderly women with comorbidities.

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Title: Colpocleisis: reoperation risk and risk of uterine and vaginal cancer: A nationwide cohort study
Authors: Marie Hammerbak-Andersen
Niels Klarskov
Karen R. Husby
Publication date: 22-05-2023
Publisher: Springer International Publishing
Keywords: Vaginal Cancer
Vaginal Cancer
Hysterectomy
Published in: International Urogynecology Journal / Issue 10/2023
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-023-05566-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Colpocleisis: reoperation risk and risk of uterine and vaginal cancer: A nationwide cohort study

Abstract

Introduction and hypothesis

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusion

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