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01-11-2006 | Short Communication

Vagal postganglionic origin of vasoactive intestinal polypeptide (VIP) mediating the vagal tachycardia

Authors: F. Markos, H. M. Snow

Published in: European Journal of Applied Physiology | Issue 4/2006

Abstract

Our aim was to confirm the role of postganglionic vagal fibres and vasoactive intestinal polypeptide (VIP) in mediating the vagal tachycardia in anaesthetised dogs. Vagal postganglionic stimulation after atenolol (1 mg/kg) and hexamethonium (10 mg/kg) caused a bradycardia (40 beats/min, n = 2), after atropine (0.5 mg/kg i.v.) the resulting tachycardia (37 beats/min) was attenuated by VIP receptor antagonism with VIP (6-28) (100 μg i.c.) by approximately 50%. VIP release from vagal postganglionic fibres mediates the vagal tachycardia.

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Title: Vagal postganglionic origin of vasoactive intestinal polypeptide (VIP) mediating the vagal tachycardia
Authors: F. Markos
H. M. Snow
Publication date: 01-11-2006
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 4/2006
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-006-0270-1

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Vagal postganglionic origin of vasoactive intestinal polypeptide (VIP) mediating the vagal tachycardia

Abstract

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Abstract

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