Skip to main content
Top
Published in: Surgical Endoscopy 7/2021

01-07-2021 | Vacuum Therapy | 2020 SAGES Oral

S116: Impact of incisional negative pressure wound therapy on surgical site infection after complex incisional hernia repair: a retrospective matched cohort study

Authors: Brent Hopkins, Jules Eustache, Olivia Ganescu, Josie Cipolla, Pepa Kaneva, Gerald M. Fried, Kosar Khwaja, Melina Vassiliou, Paola Fata, Lawrence Lee, Liane S. Feldman

Published in: Surgical Endoscopy | Issue 7/2021

Login to get access

Abstract

Introduction

Incisional negative pressure wound therapy (iNPWT) may reduce surgical site infections (SSI), which can have devastating consequences after incisional hernia repair. Few comparative studies investigate the effectiveness of this wound management strategy in this population. The objective of this study is to determine the effect of iNPWT on the incidence of SSI after complex incisional hernia repair.

Methods

All adult patients undergoing open incisional hernia repair at a single center from 2016 to 2019 were reviewed. A commercial iNPWT dressing was used at the discretion of the surgeon. Patients were grouped by type of dressing; iNPWT and standard sterile dressings (SSD). Coarsened exact matching was used to create balanced cohorts for comparison using age, sex, American Society of Anesthesiologists classification, wound classification, and surgical urgency. The primary outcome was the composite incidence of superficial and deep SSI within 30 days. Secondary outcomes included non-infectious surgical site occurrences (SSO), overall complications, length of stay (LOS), emergency department visits, and readmission at 30 days.

Results

134 patients underwent complex hernia repair, with 114 patients included after matching (34 iNPWT, 51 SSD). Composite incidence of superficial and deep SSI was 19.3% (11.8% vs. 27.5%, p = 0.107), with significantly lower rates of deep SSI in patients receiving iNPWT (2.9% vs. 17.6%, p = 0.045). After accounting for residual differences between groups, iNPWT was associated with decreased incidence of composite SSI (RR 0.36, 95% CI [0.16, 0.87]). Median LOS was longer in patients with iNPWT (7 vs. 5 days, p = 0.001). There were no differences in SSO, overall complications, readmission, or emergency department visits.

Conclusion

In patients undergoing incisional hernia repair, the use of iNPWT was associated with a lower incidence of SSI at 30 days. Future studies should focus on cost effectiveness of iNPWT, its impact on long-term hernia recurrences, and the identification of patient selection criteria in this population.
Literature
1.
go back to reference Ventral Hernia Working G, Breuing K, Butler CE, Ferzoco S, Franz M, Hultman CS, Kilbridge JF, Rosen M, Silverman RP, Vargo D (2010) Incisional ventral hernias: review of the literature and recommendations regarding the grading and technique of repair. Surgery 148:544–558CrossRef Ventral Hernia Working G, Breuing K, Butler CE, Ferzoco S, Franz M, Hultman CS, Kilbridge JF, Rosen M, Silverman RP, Vargo D (2010) Incisional ventral hernias: review of the literature and recommendations regarding the grading and technique of repair. Surgery 148:544–558CrossRef
2.
go back to reference Kanters AE, Krpata DM, Blatnik JA, Novitsky YM, Rosen MJ (2012) Modified hernia grading scale to stratify surgical site occurrence after open ventral hernia repairs. J Am Coll Surg 215:787–793CrossRef Kanters AE, Krpata DM, Blatnik JA, Novitsky YM, Rosen MJ (2012) Modified hernia grading scale to stratify surgical site occurrence after open ventral hernia repairs. J Am Coll Surg 215:787–793CrossRef
3.
go back to reference Iqbal CW, Pham TH, Joseph A, Mai J, Thompson GB, Sarr MG (2007) Long-term outcome of 254 complex incisional hernia repairs using the modified Rives-Stoppa technique. World J Surg 31:2398–2404CrossRef Iqbal CW, Pham TH, Joseph A, Mai J, Thompson GB, Sarr MG (2007) Long-term outcome of 254 complex incisional hernia repairs using the modified Rives-Stoppa technique. World J Surg 31:2398–2404CrossRef
4.
go back to reference Lauren Paton B, Novitsky YW, Zerey M, Sing RF, Kercher KW, Todd Heniford B (2007) Management of infections of polytetrafluoroethylene-based mesh. Surg Infect 8:337–342CrossRef Lauren Paton B, Novitsky YW, Zerey M, Sing RF, Kercher KW, Todd Heniford B (2007) Management of infections of polytetrafluoroethylene-based mesh. Surg Infect 8:337–342CrossRef
5.
go back to reference Cox TC, Blair LJ, Huntington CR, Colavita PD, Prasad T, Lincourt AE, Heniford BT, Augenstein VA (2016) The cost of preventable comorbidities on wound complications in open ventral hernia repair. J Surg Res 206:214–222CrossRef Cox TC, Blair LJ, Huntington CR, Colavita PD, Prasad T, Lincourt AE, Heniford BT, Augenstein VA (2016) The cost of preventable comorbidities on wound complications in open ventral hernia repair. J Surg Res 206:214–222CrossRef
6.
go back to reference Plymale MA, Ragulojan R, Davenport DL, Roth JS (2017) Ventral and incisional hernia: the cost of comorbidities and complications. Surg Endosc 31:341–351CrossRef Plymale MA, Ragulojan R, Davenport DL, Roth JS (2017) Ventral and incisional hernia: the cost of comorbidities and complications. Surg Endosc 31:341–351CrossRef
7.
go back to reference Rosen MJ, Bauer JJ, Harmaty M, Carbonell AM, Cobb WS, Matthews B, Goldblatt MI, Selzer DJ, Poulose BK, Hansson BME, Rosman C, Chao JJ, Jacobsen GR (2017) Multicenter, prospective, longitudinal study of the recurrence, surgical site infection, and quality of life after contaminated ventral hernia repair using biosynthetic absorbable mesh: the COBRA study. Ann Surg 265:205–211CrossRef Rosen MJ, Bauer JJ, Harmaty M, Carbonell AM, Cobb WS, Matthews B, Goldblatt MI, Selzer DJ, Poulose BK, Hansson BME, Rosman C, Chao JJ, Jacobsen GR (2017) Multicenter, prospective, longitudinal study of the recurrence, surgical site infection, and quality of life after contaminated ventral hernia repair using biosynthetic absorbable mesh: the COBRA study. Ann Surg 265:205–211CrossRef
9.
go back to reference Hyldig N, Birke-Sorensen H, Kruse M, Vinter C, Joergensen JS, Sorensen JA, Mogensen O, Lamont RF, Bille C (2016) Meta-analysis of negative-pressure wound therapy for closed surgical incisions. Br J Surg 103:477–486CrossRef Hyldig N, Birke-Sorensen H, Kruse M, Vinter C, Joergensen JS, Sorensen JA, Mogensen O, Lamont RF, Bille C (2016) Meta-analysis of negative-pressure wound therapy for closed surgical incisions. Br J Surg 103:477–486CrossRef
11.
go back to reference World Health Organization (2018) Global guidelines for the prevention of surgical site infections. World Health Organization, Geneva World Health Organization (2018) Global guidelines for the prevention of surgical site infections. World Health Organization, Geneva
12.
go back to reference Chopra K, Gowda AU, Morrow C, Holton L 3rd, Singh DP (2016) The economic impact of closed-incision negative-pressure therapy in high-risk abdominal incisions: a cost-utility analysis. Plast Reconstr Surg 137:1284–1289CrossRef Chopra K, Gowda AU, Morrow C, Holton L 3rd, Singh DP (2016) The economic impact of closed-incision negative-pressure therapy in high-risk abdominal incisions: a cost-utility analysis. Plast Reconstr Surg 137:1284–1289CrossRef
13.
go back to reference Slater NJ, Montgomery A, Berrevoet F, Carbonell AM, Chang A, Franklin M, Kercher KW, Lammers BJ, Parra-Davilla E, Roll S, Towfigh S, van Geffen E, Conze J, van Goor H (2014) Criteria for definition of a complex abdominal wall hernia. Hernia 18:7–17CrossRef Slater NJ, Montgomery A, Berrevoet F, Carbonell AM, Chang A, Franklin M, Kercher KW, Lammers BJ, Parra-Davilla E, Roll S, Towfigh S, van Geffen E, Conze J, van Goor H (2014) Criteria for definition of a complex abdominal wall hernia. Hernia 18:7–17CrossRef
14.
go back to reference Berger RL, Li LT, Hicks SC, Davila JA, Kao LS, Liang MK (2013) Development and validation of a risk-stratification score for surgical site occurrence and surgical site infection after open ventral hernia repair. J Am Coll Surg 217:974–982CrossRef Berger RL, Li LT, Hicks SC, Davila JA, Kao LS, Liang MK (2013) Development and validation of a risk-stratification score for surgical site occurrence and surgical site infection after open ventral hernia repair. J Am Coll Surg 217:974–982CrossRef
15.
go back to reference Liang MK, Goodenough CJ, Martindale RG, Roth JS, Kao LS (2015) External validation of the ventral hernia risk score for prediction of surgical site infections. Surg Infect 16:36–40CrossRef Liang MK, Goodenough CJ, Martindale RG, Roth JS, Kao LS (2015) External validation of the ventral hernia risk score for prediction of surgical site infections. Surg Infect 16:36–40CrossRef
16.
go back to reference Centers for Disease C (2019) National Healthcare Safety Network Surveillance (NHSN) Patient Safety Component Manual 2019 Centers for Disease C (2019) National Healthcare Safety Network Surveillance (NHSN) Patient Safety Component Manual 2019
17.
go back to reference Centers for Disease C (2016) 2014 National and State Healthcare associated infections progress report. Centers for Disease Control Centers for Disease C (2016) 2014 National and State Healthcare associated infections progress report. Centers for Disease Control
18.
go back to reference Iacus, M S, King, Gary, Porro, Giuseppe (2018) cem: coarsened exact matching Iacus, M S, King, Gary, Porro, Giuseppe (2018) cem: coarsened exact matching
19.
go back to reference Stevens GA, King G, Shibuya K (2010) Deaths from heart failure: using coarsened exact matching to correct cause-of-death statistics. Popul Health Metr 8:6CrossRef Stevens GA, King G, Shibuya K (2010) Deaths from heart failure: using coarsened exact matching to correct cause-of-death statistics. Popul Health Metr 8:6CrossRef
20.
go back to reference Wells AR, Hamar B, Bradley C, Gandy WM, Harrison PL, Sidney JA, Coberley CR, Rula EY, Pope JE (2013) Exploring robust methods for evaluating treatment and comparison groups in chronic care management programs. Popul Health Manag 16:35–45CrossRef Wells AR, Hamar B, Bradley C, Gandy WM, Harrison PL, Sidney JA, Coberley CR, Rula EY, Pope JE (2013) Exploring robust methods for evaluating treatment and comparison groups in chronic care management programs. Popul Health Manag 16:35–45CrossRef
21.
go back to reference Blackwell M, Iacus S, King G, Porro G (2009) Cem: coarsened exact matching in stata. Stata J 9:524–546CrossRef Blackwell M, Iacus S, King G, Porro G (2009) Cem: coarsened exact matching in stata. Stata J 9:524–546CrossRef
22.
go back to reference Tran BNN, Johnson AR, Shen C, Lee BT, Lee ES (2019) Closed-incision negative-pressure therapy efficacy in abdominal wall reconstruction in high-risk patients: a meta-analysis. J Surg Res 241:63–71CrossRef Tran BNN, Johnson AR, Shen C, Lee BT, Lee ES (2019) Closed-incision negative-pressure therapy efficacy in abdominal wall reconstruction in high-risk patients: a meta-analysis. J Surg Res 241:63–71CrossRef
23.
go back to reference Sahebally SM, McKevitt K, Stephens I, Fitzpatrick F, Deasy J, Burke JP, McNamara D (2018) Negative pressure wound therapy for closed laparotomy incisions in general and colorectal surgery: a systematic review and meta-analysis. JAMA Surg 153:e183467CrossRef Sahebally SM, McKevitt K, Stephens I, Fitzpatrick F, Deasy J, Burke JP, McNamara D (2018) Negative pressure wound therapy for closed laparotomy incisions in general and colorectal surgery: a systematic review and meta-analysis. JAMA Surg 153:e183467CrossRef
24.
go back to reference Xia C-Y, Yu A-X, Qi B, Zhou M, Li Z-H, Wang W-Y (2014) Analysis of blood flow and local expression of angiogenesis-associated growth factors in infected wounds treated with negative pressure wound therapy. Mol Med Rep 9:1749–1754CrossRef Xia C-Y, Yu A-X, Qi B, Zhou M, Li Z-H, Wang W-Y (2014) Analysis of blood flow and local expression of angiogenesis-associated growth factors in infected wounds treated with negative pressure wound therapy. Mol Med Rep 9:1749–1754CrossRef
25.
go back to reference Wilkes RP, Kilpad DV, Zhao Y, Kazala R, McNulty A (2012) Closed incision management with negative pressure wound therapy (CIM): biomechanics. Surg Innov 19:67–75CrossRef Wilkes RP, Kilpad DV, Zhao Y, Kazala R, McNulty A (2012) Closed incision management with negative pressure wound therapy (CIM): biomechanics. Surg Innov 19:67–75CrossRef
26.
go back to reference Vargo D (2012) Negative pressure wound therapy in the prevention of wound infection in high risk abdominal wound closures. Am J Surg 204:1021–1023CrossRef Vargo D (2012) Negative pressure wound therapy in the prevention of wound infection in high risk abdominal wound closures. Am J Surg 204:1021–1023CrossRef
27.
go back to reference Gassman A, Mehta A, Bucholdz E, Abthani A, Guerra O, Maclin MM Jr, Esposito T, Thomas C (2015) Positive outcomes with negative pressure therapy over primarily closed large abdominal wall reconstruction reduces surgical site infection rates. Hernia 19:273–278CrossRef Gassman A, Mehta A, Bucholdz E, Abthani A, Guerra O, Maclin MM Jr, Esposito T, Thomas C (2015) Positive outcomes with negative pressure therapy over primarily closed large abdominal wall reconstruction reduces surgical site infection rates. Hernia 19:273–278CrossRef
28.
go back to reference de Vries FEE, Atema JJ, Lapid O, Obdeijn MC, Boermeester MA (2017) Closed incision prophylactic negative pressure wound therapy in patients undergoing major complex abdominal wall repair. Hernia 21:583–589CrossRef de Vries FEE, Atema JJ, Lapid O, Obdeijn MC, Boermeester MA (2017) Closed incision prophylactic negative pressure wound therapy in patients undergoing major complex abdominal wall repair. Hernia 21:583–589CrossRef
29.
go back to reference Soares KC, Baltodano PA, Hicks CW, Cooney CM, Olorundare IO, Cornell P, Burce K, Eckhauser FE (2015) Novel wound management system reduction of surgical site morbidity after ventral hernia repairs: a critical analysis. Am J Surg 209:324–332CrossRef Soares KC, Baltodano PA, Hicks CW, Cooney CM, Olorundare IO, Cornell P, Burce K, Eckhauser FE (2015) Novel wound management system reduction of surgical site morbidity after ventral hernia repairs: a critical analysis. Am J Surg 209:324–332CrossRef
30.
go back to reference Pauli EM, Krpata DM, Novitsky YW, Rosen MJ (2013) Negative pressure therapy for high-risk abdominal wall reconstruction incisions. Surg Infect 14:270–274CrossRef Pauli EM, Krpata DM, Novitsky YW, Rosen MJ (2013) Negative pressure therapy for high-risk abdominal wall reconstruction incisions. Surg Infect 14:270–274CrossRef
31.
go back to reference Condé-Green A, Chung TL, Holton LH 3rd, Hui-Chou HG, Zhu Y, Wang H, Zahiri H, Singh DP (2013) Incisional negative-pressure wound therapy versus conventional dressings following abdominal wall reconstruction: a comparative study. Ann Plast Surg 71:394–397CrossRef Condé-Green A, Chung TL, Holton LH 3rd, Hui-Chou HG, Zhu Y, Wang H, Zahiri H, Singh DP (2013) Incisional negative-pressure wound therapy versus conventional dressings following abdominal wall reconstruction: a comparative study. Ann Plast Surg 71:394–397CrossRef
33.
go back to reference Diaconu SC, McNichols CHL, Ngaage LM, Liang Y, Ikheloa E, Bai J, Grant MP, Nam AJ, Rasko YM (2018) Closed-incision negative-pressure therapy decreases complications in ventral hernia repair with concurrent panniculectomy. Hernia 24(1):49–55CrossRef Diaconu SC, McNichols CHL, Ngaage LM, Liang Y, Ikheloa E, Bai J, Grant MP, Nam AJ, Rasko YM (2018) Closed-incision negative-pressure therapy decreases complications in ventral hernia repair with concurrent panniculectomy. Hernia 24(1):49–55CrossRef
34.
go back to reference Hicks CW, Poruk KE, Baltodano PA, Soares KC, Azoury SC, Cooney CM, Cornell P, Eckhauser FE (2016) Long-term outcomes of sandwich ventral hernia repair paired with hybrid vacuum-assisted closure. J Surg Res 204:282–287CrossRef Hicks CW, Poruk KE, Baltodano PA, Soares KC, Azoury SC, Cooney CM, Cornell P, Eckhauser FE (2016) Long-term outcomes of sandwich ventral hernia repair paired with hybrid vacuum-assisted closure. J Surg Res 204:282–287CrossRef
35.
go back to reference Rodriguez-Unda N, Soares KC, Azoury SC, Baltodano PA, Hicks CW, Burce KK, Cornell P, Cooney CM, Eckhauser FE (2015) Negative-pressure wound therapy in the management of high-grade ventral hernia repairs. J Gastrointest Surg 19:2054–2061CrossRef Rodriguez-Unda N, Soares KC, Azoury SC, Baltodano PA, Hicks CW, Burce KK, Cornell P, Cooney CM, Eckhauser FE (2015) Negative-pressure wound therapy in the management of high-grade ventral hernia repairs. J Gastrointest Surg 19:2054–2061CrossRef
36.
go back to reference Blackham AU, Farrah JP, McCoy TP, Schmidt BS, Shen P (2013) Prevention of surgical site infections in high-risk patients with laparotomy incisions using negative-pressure therapy. Am J Surg 205:647–654CrossRef Blackham AU, Farrah JP, McCoy TP, Schmidt BS, Shen P (2013) Prevention of surgical site infections in high-risk patients with laparotomy incisions using negative-pressure therapy. Am J Surg 205:647–654CrossRef
38.
go back to reference Shen P, Blackham AU, Lewis S, Clark CJ, Howerton R, Mogal HD, Dodson RM, Russell GB, Levine EA (2017) Phase II randomized trial of negative-pressure wound therapy to decrease surgical site infection in patients undergoing laparotomy for gastrointestinal, pancreatic, and peritoneal surface malignancies. J Am Coll Surg 224:726–737CrossRef Shen P, Blackham AU, Lewis S, Clark CJ, Howerton R, Mogal HD, Dodson RM, Russell GB, Levine EA (2017) Phase II randomized trial of negative-pressure wound therapy to decrease surgical site infection in patients undergoing laparotomy for gastrointestinal, pancreatic, and peritoneal surface malignancies. J Am Coll Surg 224:726–737CrossRef
Metadata
Title
S116: Impact of incisional negative pressure wound therapy on surgical site infection after complex incisional hernia repair: a retrospective matched cohort study
Authors
Brent Hopkins
Jules Eustache
Olivia Ganescu
Josie Cipolla
Pepa Kaneva
Gerald M. Fried
Kosar Khwaja
Melina Vassiliou
Paola Fata
Lawrence Lee
Liane S. Feldman
Publication date
01-07-2021
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 7/2021
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-020-07857-1

Other articles of this Issue 7/2021

Surgical Endoscopy 7/2021 Go to the issue