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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-04-2021 | Uveitis | Inflammatory Disorders

Relationship between changes in retinal nerve fiber layer thickness measured by SD-OCT and changes in visual field parameters in birdshot chorioretinopathy

Authors: Aurélia Gave, Lucile Cotella, José Labarere, Florent Aptel, Christophe Chiquet

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 4/2021

Abstract

Purpose

To describe the structure–function relationship in birdshot chorioretinopathy (BSCR) using visual field data and peri-papillary retinal nerve fiber thickness (RNFL).

Methods

A total of 21 patients (34 eyes) with BSCR were evaluated prospectively from 2014 to 2018 (IMAGE-EYE cohort). Functional tests included measurement of visual acuity and visual field (30-2 SITA standard). Anatomical tests included fluorescein angiography, indocyanine green angiography, and spectral domain optical coherence tomography.

Results

Most of the patients were female (57%) with a mean age of 62 ± 8 years. Mean follow-up was 2.3 ± 0.6 years. Structural examination results were significantly modified in contrast to functional test results, with a significant reduction in mean RNFL (2.49 μm, p < 0.01), temporal RNFL (− 1.68 μm; p = 0.03) and lower nasal RNFL (− 2.83 μm; p = 0.003). A significant linear relationship was found (p = 0.001) between the visual field deficit (mean deviation (MD)) and the Napierian logarithm of the mean RNFL thickness.

Conclusion

We found a subtle structural deterioration of the optic nerve (RNFL) during the follow-up, but not of the visual field. The significant relationship between structural (RNFL thickness) and functional measures (mean deviation) also supports the idea that RNFL thickness measurements could be useful for the mid-term monitoring of BSCR patients.

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Title: Relationship between changes in retinal nerve fiber layer thickness measured by SD-OCT and changes in visual field parameters in birdshot chorioretinopathy
Authors: Aurélia Gave
Lucile Cotella
José Labarere
Florent Aptel
Christophe Chiquet
Publication date: 01-04-2021
Publisher: Springer Berlin Heidelberg
Keyword: Uveitis
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 4/2021
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04968-2

At a glance: The STEP trials

Springer Medicine

Relationship between changes in retinal nerve fiber layer thickness measured by SD-OCT and changes in visual field parameters in birdshot chorioretinopathy

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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