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Current Heart Failure Reports
Published in: Current Heart Failure Reports 3/2015

01-06-2015 | Pharmacologic Therapy (W H W Tang, Section Editor)

Utilizing Cardiac Biomarkers to Detect and Prevent Chemotherapy-Induced Cardiomyopathy

Authors: Dhssraj Singh, Akanksha Thakur, W. H. Wilson Tang

Published in: Current Heart Failure Reports | Issue 3/2015

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Abstract

The success achieved in advances in cancer therapy has been marred by development of cardiotoxicity, which causes significant morbidity and mortality. This has led to the development of surveillance protocols for cardiotoxicity utilizing multimodality imaging techniques and investigation of various drugs to treat and prevent cardiotoxicity in this subset of patients. Cardiac biomarkers hold important diagnostic and prognostic value in various cardiac diseases. In this review, we discuss the use of biomarkers in patients receiving chemotherapy, highlighting data behind the use of troponin, B-type natriuretic peptide, and myeloperoxidase. We also discuss the use of dexrazoxane, angiotensin-converting enzyme inhibitors, and beta blockers in the treatment and prevention of chemotherapy-induced cardiotoxicity. Cardiac biomarkers may serve an important role in selecting patients that are at high risk of cardiotoxicity and can potentially be used to guide the administration of drugs to treat and prevent cardiotoxicity.
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Metadata
Title
Utilizing Cardiac Biomarkers to Detect and Prevent Chemotherapy-Induced Cardiomyopathy
Authors
Dhssraj Singh
Akanksha Thakur
W. H. Wilson Tang
Publication date
01-06-2015
Publisher
Springer US
Published in
Current Heart Failure Reports / Issue 3/2015
Print ISSN: 1546-9530
Electronic ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-015-0258-4

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